Zobrazeno 1 - 10
of 96
pro vyhledávání: '"John W.M. Martens"'
Autor:
Bircan Coban, Zi Wang, Chen-yi Liao, Klara Beslmüller, Mieke A.M. Timmermans, John W.M. Martens, Jasmijn H.M. Hundscheid, Bram Slutter, Annelien J.M. Zweemer, Elsa Neubert, Erik H.J. Danen
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109738- (2024)
Summary: Tumor tissues often contain high extracellular adenosine, promoting an immunosuppressed environment linked to mesenchymal transition and immune evasion. Here, we show that loss of the epithelial transcription factor, GRHL2, triggers NT5E/CD7
Externí odkaz:
https://doaj.org/article/7db94f8d0efd4c47abfa7e432f94c9c3
Autor:
Stefan Sleijfer, John W.M. Martens, Harmen J.G. van de Werken, Corine M. Beaufort, Anieta M. Sieuwerts, Job van Riet, Nikolas H. Stoecklein, Jaco Kraan, Yorick Sandberg, Peter A. W. te Boekhorst, Martijn P. Lolkema, Wytske M. van Weerden, Anouk C. de Jong, Paul Hamberg, S. Erkens-Schulze, Lisanne F. van Dessel, L. Mout, Thomas L.C. Woo, Ronald de Wit, Rui P L Neves
Publikováno v:
European Journal of Cancer, 150, 179-189. Elsevier Ltd.
Background: Circulating tumour cell (CTC)–derived organoids have the potential to provide a powerful tool for personalised cancer therapy but are restrained by low CTC numbers provided by blood samples. Here, we used diagnostic leukapheresis (DLA)
Autor:
Jaco Kraan, Leonie L. Zeune, Leon W.M.M. Terstappen, John W.M. Martens, Mai Van, Esther Oomen-de Hoop, Stefan Sleijfer, Pauline A J Mendelaar
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 15, Iss 1, Pp 116-125 (2021)
Molecular oncology, 15(1), 116-125. Elsevier
Molecular Oncology, 15(1), 116-125. John Wiley & Sons Ltd.
Molecular Oncology, Vol 15, Iss 1, Pp 116-125 (2021)
Molecular oncology, 15(1), 116-125. Elsevier
Molecular Oncology, 15(1), 116-125. John Wiley & Sons Ltd.
Molecular characterization of circulating tumor cells is of high clinical relevance. Since circulating tumor cell (CTC) detection and isolation often rely on cell dimensions, we determined the size of 71 612 CellSearch‐detected CTCs using accept so
Autor:
Martijn P. Lolkema, Joost Gribnau, John W.M. Martens, Vanja de Weerd, Ruben Boers, Zakia Azmani, Lisanne F. van Dessel, Marjolijn M. J. van der Put, Cornelis Verhoef, Lindsay Angus, Dirk J. Grünhagen, Teoman Deger, Joachim Boers, Wilfred F. J. van IJcken, Saskia M. Wilting, Stefan Sleijfer
Publikováno v:
Clinical Epigenetics
Clinical Epigenetics, 13(1):196. BioMed Central Ltd.
Clinical Epigenetics, 13(1):196. BioMed Central Ltd.
Background DNA methylation detection in liquid biopsies provides a highly promising and much needed means for real-time monitoring of disease load in advanced cancer patient care. Compared to the often-used somatic mutations, tissue- and cancer-type
Autor:
Hayri E. Balcioglu, Iris Nederlof, Mieke Timmermans, John W.M. Martens, Reno Debets, Renée Foekens, Olga I. Isaeva, Rebecca Wijers, Hugo M. Horlings, Marcel Smid, Anita M. A. C. Trapman-Jansen, Dora Hammerl, Roberto Salgado, Leonie Voorwerk, Marleen Kok
Publikováno v:
Nature Communications, 12(1):5668. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Only a subgroup of triple-negative breast cancer (TNBC) responds to immune checkpoint inhibitors (ICI). To better understand lack of response to ICI, we analyze 681 TNBCs for spatial immune cell contextures in relation to clinical outcomes and pathwa
Autor:
Chris J. de Witte, Roel Janssen, Wigard P. Kloosterman, Martijn P. Lolkema, Christina Stangl, Markus J. van Roosmalen, Jose Espejo Valle-Inclan, Anouk C. de Jong, Jean C. A. Helmijr, Sam de Blank, Maurice P.H.M. Jansen, Ivo Renkens, John W.M. Martens, Lisanne F. van Dessel
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Genome Medicine
Genome Medicine, 13(1):86. BioMed Central Ltd.
Genome Medicine
Genome Medicine, 13(1):86. BioMed Central Ltd.
Here, we describe a novel approach for rapid discovery of a set of tumor-specific genomic structural variants (SVs), based on a combination of low coverage cancer genome sequencing using Oxford Nanopore with an SV calling and filtering pipeline. We a
Autor:
Teoman Deger, Saskia M. Wilting, Stefan Sleijfer, Elisabeth M. Jongbloed, Agnes Jager, John W.M. Martens
Publikováno v:
Cancers, Vol 13, Iss 1811, p 1811 (2021)
Cancers
Cancers
Simple Summary Currently, the most commonly used method to monitor response to treatment in metastatic breast cancer patients is by radiological imaging. However, these imaging techniques are relatively insensitive and give little to no insight into
Autor:
John W.M. Martens, Sylvia E. Le Dévédec, Gerhard A. Burger, Leo S. Price, Liesanne Wolters, Marcel Smid, Peter Stoilov, Bram Herpers, Kuan Yan, Bob van de Water, Esmee Koedoot
Publikováno v:
Scientific Reports, 11, 7529
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, 11(1):7259. Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, 11(1):7259. Nature Publishing Group
Screening for effective candidate drugs for breast cancer has shifted from two-dimensional (2D) to three-dimensional (3D) cultures. Here we systematically compared the transcriptomes of these different culture conditions by RNAseq of 14 BC cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb9daee7c16d87843e377180eabd4c3
https://hdl.handle.net/1887/3166006
https://hdl.handle.net/1887/3166006
Autor:
Steven Van Laere, Colin A. Purdie, John A. Foekens, Gaëten MacGrogan, Marcel Smid, Andrew Futreal, Vanja de Weerd, Paul N. Span, Marc J. van de Vijver, Jorunn E. Eyfjord, Serena Nik-Zainal, F. Germán Rodríguez-González, Roberto Salgado, Peter T. Simpson, Christine Desmedt, Wendy J. C. Prager-van der Smissen, Fred C.G.J. Sweep, Tari A. King, Adam Butler, Michael R. Stratton, Carlos Caldas, Gert Van den Eynden, Sunil R. Lakhani, Saskia M. Wilting, Alastair M. Thompson, Angelo Paradiso, John W.M. Martens, Anne Vincent-Salomon, Johan Staaf, Anne van Galen, Sancha Martin, Hendrik G. Stunnenberg, Annegien Broeks, Andrea L. Richardson, Anne Lise Børresen-Dale, Helen Davies, Michelle van der Vlugt-Daane, Katharina Uhr, Stian Knappskog, Alain Viari, Anieta M. Sieuwerts
Publikováno v:
Genome Research
Genome Research, 29(3), 356-366. Cold Spring Harbor Laboratory Press
Genome research, 29(3), 356-366. Cold Spring Harbor Laboratory Press
Genome Research, Cold Spring Harbor Laboratory Press, 2019, 29 (3), pp.356-366. ⟨10.1101/gr.238121.118⟩
Genome Research, 29, 356-366
Genome research, 29 (3
Genome research
Genome Research, 29, 3, pp. 356-366
Genome Research, 2019, 29 (3), pp.356-366. ⟨10.1101/gr.238121.118⟩
Genome Research, 29(3), 356-366. Cold Spring Harbor Laboratory Press
Genome research, 29(3), 356-366. Cold Spring Harbor Laboratory Press
Genome Research, Cold Spring Harbor Laboratory Press, 2019, 29 (3), pp.356-366. ⟨10.1101/gr.238121.118⟩
Genome Research, 29, 356-366
Genome research, 29 (3
Genome research
Genome Research, 29, 3, pp. 356-366
Genome Research, 2019, 29 (3), pp.356-366. ⟨10.1101/gr.238121.118⟩
Publisher's version (útgefin grein)
Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to id
Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to id
Autor:
Anieta M. Sieuwerts, Guido Jenster, Michelle van der Vlugt-Daane, Lisanne F. van Dessel, Hicret Coban, Marjolein Gerritsen, Martijn P. Lolkema, Jean A. Helmijr, Martin E. van Royen, Nick Beije, Stefan Sleijfer, Natasja Dits, John W.M. Martens, Silvia Rita Vitale, Maurice P.H.M. Jansen, Paolo Vigneri
Publikováno v:
BMC Cancer
BMC Cancer, 21(1):315. BioMed Central Ltd.
BMC Cancer, Vol 21, Iss 1, Pp 1-17 (2021)
BMC Cancer, 21(1):315. BioMed Central Ltd.
BMC Cancer, Vol 21, Iss 1, Pp 1-17 (2021)
Background Extracellular vesicles (EVs) are actively secreted by cells into body fluids and contain nucleic acids of the cells they originate from. The goal of this study was to detect circulating tumor-derived EVs (ctEVs) by mutant mRNA transcripts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d059bdab35523740fff3960f19c6b6c
https://hdl.handle.net/20.500.11769/548853
https://hdl.handle.net/20.500.11769/548853