Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Jeffrey W. Clark"'
Autor:
Christine E. Eyler, Lorraine C. Drapek, Nora Horick, Jeffrey W. Clark, David H. Berger, David P. Ryan, Sam Klempner, Grace M. Lee, Aparna Raj Parikh, Daniel Kim, Florence K. Keane, Eric Roeland, John T. Mullen, Theodore S. Hong, Jennifer Y. Wo, Guichao Li, Jill N. Allen
Publikováno v:
Annals of Surgical Oncology. 29:242-252
The optimal timing of chemoradiotherapy (CRT) for patients with localized gastric cancer remains unclear. This study aimed to compare the survival outcomes between neoadjuvant and postoperative CRT for patients with gastric and gastroesophageal junct
Autor:
Jennifer Y. Wo, Ryan D. Nipp, David P. Ryan, Emily E. Van Seventer, Lawrence S. Blaszkowsky, Jill N. Allen, Heather A. Shahzade, James C. Cusack, Yupeng He, Hiroko Kunitake, Liliana Bordeianou, Lipika Goyal, Motaz Qadan, Samuel J. Klempner, Jon Dubois, Kathryn Fosbenner, AmirAli Talasaz, Benchun Miao, Cristina R. Ferrone, Bruce J. Giantonio, John H. Carmichael, Jeffrey W. Clark, Victoria M. Raymond, Susannah T. Phillips, Yojan S. Shah, Islam Baiev, Aparna Raj Parikh, Colin D. Weekes, Ariel Jaimovich, Genevieve M. Boland, Ryan B. Corcoran, David H. Berger, Joy X. Jarnagin, Katie Kanter, Nihaarika Sharma, Giulia Siravegna, Isobel J Fetter, Madeleine Fish, Theodore S. Hong, Eric Roeland, Joseph W. Franses, Rocco Ricciardi, Anna Hartwig
Publikováno v:
Clinical Cancer Research. 27:5586-5594
Purpose: Detection of persistent circulating tumor DNA (ctDNA) after curative-intent surgery can identify patients with minimal residual disease (MRD) who will ultimately recur. Most ctDNA MRD assays require tumor sequencing to identify tumor-derived
Autor:
Uvette Lou, Lawrence S. Blaszkowsky, Vineet K. Raghu, Sean P. Murphy, John W. Clark, Zsofia D. Drobni, Erica Tavares, Ramya C. Mosarla, Hannah K Gilman, Raza M. Alvi, Maeve Jones-O'Connor, Tomas G. Neilan, Colin D. Weekes, Sarah Hartmann, Amna Zafar, Matthew Lei, Jeffrey W. Clark
Publikováno v:
JACC: CardioOncology. 3:101-109
Background Coronary vasospasm is a recognized side effect of 5-fluorouracil (5-FU). There are limited and conflicting data on the incidence, risk factors, and prognostic effect of 5-FU–associated vasospasm. Objectives This study sought to assess th
Autor:
Aparna Raj Parikh, Theodore S. Hong, Selena S. Li, Jeffrey W. Clark, Christina L. Costantino, John T. Mullen, Samuel J. Klempner, Jennifer Y. Wo
Publikováno v:
Annals of Surgical Oncology. 28:2856-2865
Data are limited concerning the survival outcomes of locally advanced gastric cancer patients according to the multimodality therapy (MMT) administered. Single institution, retrospective analysis of 235 patients with locally advanced gastric cancer f
Autor:
Jon Dubois, Kathryn Fosbenner, Amirkasra Mojtahed, Bruce J. Giantonio, Aparna Raj Parikh, Nora Horick, Colin D. Weekes, Eric Roeland, Lipika Goyal, Areej El-Jawahri, Samuel J. Klempner, Ryan D. Nipp, Emily E. Van Seventer, Therese M. Mulvey, Joseph W. Franses, Jill N. Allen, David P. Ryan, Katie Kanter, Jeffrey W. Clark, Lawrence S. Blaszkowsky, Ryan B. Corcoran, Madeleine Fish
Publikováno v:
Cancer. 127:619-627
BACKGROUND Patient-reported outcomes (PROs) assessing quality of life (QOL) and symptom burden correlate with clinical outcomes in patients with cancer. However, to the authors' knowledge, data regarding associations between PROs and treatment respon
Autor:
Brian M. Wolpin, Jennifer A. Chan, Raymond C. Wadlow, Kimmie Ng, Amanda Carpenter, Lipika Goyal, Thomas A. Abrams, Rebecca S. Heist, Deborah Schrag, Eunice L. Kwak, Jeffrey W. Clark, Surendra Pal Chaudhary, David P. Ryan, Wolfram Goessling, Peter C. Enzinger, Nadine Jackson McCleary, Jill N. Allen
Publikováno v:
Investigational New Drugs. 38:1533-1539
Subsets of esophagogastric (EG) cancers harbor genetic abnormalities, including amplification of HER2, MET, or FGFR2 or mutations in PIK3CA, EGFR, or BRAF. Ganetespib which is a novel triazolone heterocyclic inhibitor of HSP90, is a potentially biolo
Autor:
Justin F. Gainor, Chin Hur, Angela C. Tramontano, James A. Torchia, Jacqueline N. Chu, Daniel C. Chung, Kerry L. Reynolds, Jeffrey W. Clark, Sassan Ostvar, Jin G. Choi
Publikováno v:
Cancer. 125:278-289
Background Patients with microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) metastatic colorectal cancer (mCRC) show a significant response to checkpoint inhibitor therapies, but the economic impact of these therapies is unknown
Autor:
Kimmie Ng, Aaron R. Thorner, George D. Demetri, Lauren K. Brais, Emma Reilly, Jeffrey A. Meyerhardt, Atul B. Shinagare, Cheta Siletti, Geoffrey I. Shapiro, Jason L. Hornick, Jessica J. Lin, Matthew D. Ducar, Anna F. Farago, Ewa Sicinska, Liam F. Spurr, Andrew D. Cherniack, Laura E. MacConaill, Rachel B. Keller, Brian M. Wolpin, Azra H. Ligon, Rahul Gujrathi, Matthew Meyerson, Marios Giannakis, Ritika Abhyankar, James M. Cleary, Jeffrey W. Clark, Harshabad Singh, Anwesha Nag, Yvonne Y. Li, Matthew H. Kulke
Publikováno v:
Clin Cancer Res
Purpose: Receptor tyrosine kinase fusions in colorectal cancers are rare, but potentially therapeutically relevant. We describe clinical, molecular, and pathologic attributes of RTK fusion–associated colorectal cancer. Experimental Design: We ident
Autor:
D. Ross Camidge, Jeffrey W. Clark, Isan Chen, Keith D. Wilner, Robert G. Maki, Weiwei Tan, Sophia Randolph, Eunice L. Kwak, Ravi Salgia, Geoffrey I. Shapiro, Mark Ozeck, Yiyun Tang, James G. Christensen
Publikováno v:
Future oncology (London, England). 16(1)
Aim: This first-in-human, dose-finding study evaluated safety, pharmacokinetics and pharmacodynamics of crizotinib and established a recommended Phase II dose (RP2D) among patients with advanced solid malignancies. Patients & methods: Patients receiv
Autor:
Jeffrey W. Clark, Samuel J. Klempner, Theodore S. Hong, Aparna Raj Parikh, John T. Mullen, Jennifer Y. Wo, Eric Roeland, Selena S. Li, Brooks V. Udelsman
Publikováno v:
Journal of the American College of Surgeons. 230(6)
Background Postoperative complication (POC) adversely impacts long-term survival in patients with gastric cancer, perhaps due in part to lower rates for receipt of multimodality therapy (MMT). We sought to determine the impact of POC on MMT completio