Zobrazeno 1 - 10
of 11
pro vyhledávání: '"David J. Maloney"'
Autor:
Ganesha Rai, Joseph Jackson, Dan Crooks, Giuseppe L. Squadrito, Shun Kishimoto, Leonard M. Neckers, Tamara Anderson, Akira Yuno, Min-Jung Lee, Didier Picard, William J. Moore, Daniel J. Urban, Helen H. Hathaway, Jeffrey R. Brender, David J. Maloney, Michael A. Moses, Victor M. Darley-Usmar, Nobu Oshima, Kristin Beebe, Michelle S. Johnson, Anton Simeonov, Ajit Jadhav, Ryo Ishida, Abhinav Joshi, Matthew D. Hall, Gloria A. Benavides, Alex G. Waterson, James Mitchell, Bryan T. Mott, Donna F. Kusewitt, Jane B. Trepel, Gordon M. Stott, Larry A. Sklar, Tobie D. Lee, W. Marston Linehan, Jonathan H. Shrimp, Xin Hu, Kazutoshi Yamamoto, Jeffrey P. Norenberg, Murali Krishna, Chi V. Dang
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1798-1810.e4 (2020)
Cell reports
Cell reports
SUMMARY The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to deter
Autor:
David J. Maloney, Daniel J. Urban, Shyh-Ming Yang, Makoto Yoshioka, Xin Hu, Jeffrey Strovel, Ajit Jadhav, Matthew D. Hall
Publikováno v:
Bioorg Med Chem Lett
Extensive optimization of quinazoline-based lead 8 is described. The structure-activity relationship studies indicate the S-configuration is preferred for the phenylmorpholine substitution. Together with incorporation of a (2-hydroxyl-2-methylpropyl)
Autor:
Ajit Jadhav, Lizhen Wu, Daniel J. Jansen, Xin Hu, Mark J. Henderson, David J. Maloney, John R. Horton, Jian Cao, Stephen C. Kales, Bryan T. Mott, Anton Simeonov, Qin Yan, Shu Zhu, Wesley L. Cai, Gerald S. Shadel, Zongzhi Liu, Jocelyn F. Chen, Meiling Zhang, Xiaodong Cheng, Katherine Pohida, Ganesha Rai, Akiko Iwasaki, Sabine Lang, Matthew D. Hall
Publikováno v:
PLoS Biology
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate
Autor:
Junjun Chen, Mark A. Villamil, Anton Simeonov, Qin Liang, Zhihao Zhuang, Hongmao Sun, David J. Maloney, Thomas S. Dexheimer, Edward H. Kerns, Diane K. Luci, Andrew S. Rosenthal, Ajit Jadhav
Publikováno v:
Journal of Medicinal Chemistry
Deregulation of ubiquitin conjugation or deconjugation has been implicated in the pathogenesis of many human diseases including cancer. The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1), in association with UAF1 (USP1-associated factor
Autor:
James Mitchell, Jeffery Brender, Ganesha Rai, Shun Kishimoto, Kazutoshi Yamamoto, David J. Maloney, Keita Saito, Leonard M. Neckers, Anastasia L. Sowers, Kristin Beebe, Murali Krishna Cherukuri, Nobu Oshima, Bryan T. Mott
Publikováno v:
Cancer Research. 77:2852-2852
[aim] Increased lactate production is a feature of many neoplasms, and Lactate Dehydrogenase A (LDH-A) plays a key role in conversion of pyruvate to lactate. LDHA inhibition, therefore, is considered to be a promising approach toward developing a new
Autor:
David M. Wilson, Dorjbal Dorjsuren, Oscar M. Rueda, Stephen Chan, Vivek Mohan, Abhik Mukherjee, Ian O. Ellis, Nada Albarakati, Jennifer L. Illuzzi, Carlos Caldas, Tarek M. A. Abdel-Fatah, Rachel Abbotts, Paul M. Moseley, Srinivasan Madhusudan, Roslin Russell, Hongmao Sun, Graham Ball, Devika Agarwal, David J. Maloney, Ajit Jadhav, Anton Simeonov
Publikováno v:
Molecular oncology, vol 8, iss 7
FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of telomere stability and apoptosis. FEN1 may be dysregulated in breast and ovarian cancers and ha
Autor:
Michael C. Cavalier, David J. Weber, David J. Maloney, Mohd. Imran Ansari, Andrew Coop, Diane K. Luci, Alexander D. MacKerell, Ajit Jadhav, Paul T. Wilder, Lei Fang
Publikováno v:
Cancer Research. 76:1358-1358
An especially predictive biomarker when used in combination with other diagnostic indicators, S100B is elevated in >90% of malignant melanoma (MM) patients and its protein level correlates directly with poor survival ( Citation Format: Michael C. Cav
Autor:
Anton Simeonov, Daemyung Kim, Vaddadi N. Vyjayanti, David J. Maloney, David M. Wilson, Ajit Jadhav, Dorjbal Dorjsuren
Publikováno v:
PloS one, vol 7, iss 10
PLoS ONE, Vol 7, Iss 10, p e47974 (2012)
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e47974 (2012)
PLoS ONE
The major human apurinic/apyrimidinic endonuclease APE1 plays a pivotal role in the repair of base damage via participation in the DNA base excision repair (BER) pathway. Increased activity of APE1, often observed in tumor cells, is thought to contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f2553b9cadf239ec4a517213572f08
https://escholarship.org/uc/item/3cv3z2wq
https://escholarship.org/uc/item/3cv3z2wq
Autor:
Andrew S. Rosenthal, David J. Maloney, Ajit Jadhav, Thomas S. Dexheimer, Mark A. Villamil, Diane K. Luci, Zhihao Zhuang, Anton Simeonov, Qin Liang
Publikováno v:
Cancer Research. 74:LB-11
Protein ubiquitination is a dynamic and reversible post-translational modification that has been linked to many essential cellular processes in eukaryotes. In addition, deregulation of ubiquitin conjugation or deconjugation has been implicated in the
Autor:
Adam Yasgar, Christopher P. Austin, David J. Maloney, Christopher A. LeClair, Kian-Huat Lim, Jian-kang Jiang, Paul Shinn, Scott E. Martin, Marc Ferrer, Matthew B. Boxer, Louis M. Staudt, Paresma R. Patel, Lesley A. Mathews, Jonathan R. Keller, Brian D. Peyser, Dongbo Liu, Rajarshi Guha, Anton Simeonov, Ganesha Rai, Craig J. Thomas, Ajit Jadhav, William Leister, Bryan T. Mott, Crystal McKnight, Sam Michael, Damien Y. Duveau, Ryan M. Young
Publikováno v:
Cancer Research. 73:4543-4543
The vast majority of cancer treatments currently administered to patients consist of combinations of more than one drug via routine infusions that adhere to specific dosing schedules. It is thought that this multi-arm and time dependent approach will