Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
John W. Tobias, Mario Andres Blanco, Snahlata Singh, Sushil Kumar, Alana L. Welm, Christopher J. Lengner, Rumela Chakrabarti, Yibin Kang, Christian W. Siebel, Andres J. Klein-Szanto, Ajeya Nandi, Rohan Regulapati, Ning Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Development of chemoresistance in breast cancer patients greatly increases mortality. Thus, understanding mechanisms underlying breast cancer resistance to chemotherapy is of paramount importance to overcome this clinical challenge. Although activate
Autor:
Suraj Peri, Mitchell Cheung, Craig W. Menges, Eleonora Sementino, Andres J. Klein-Szanto, Yinfei Tan, Yuwaraj Kadariya, Kathy Q. Cai, Michael Slifker, Anna-Mariya Kukuyan, Frank J. Rauscher, Joseph R. Testa
Publikováno v:
Cancer Research. 79:4113-4123
Pleural malignant mesothelioma is a therapy-resistant cancer affecting the serosal lining of the thoracic cavity. Mutations/deletions of BAP1, CDKN2A, and NF2 are the most frequent genetic lesions in human malignant mesothelioma. We introduced variou
Autor:
Manabu Muto, Masataka Shimonosono, Takaaki Arigami, Amanda B. Muir, Masaki Mori, Takashi Kijima, Yuta Kasagi, Shinya Ohashi, Andres J. Klein-Szanto, Prasanna M. Chandramouleeswaran, Narayan G. Avadhani, Itaru Omoto, Shoji Natsugoe, Gregory G. Ginsberg, Seiji Naganuma, Veronique Giroux, Varun Sahu, Yoshiaki Shinden, Osamu Kikuchi, Devraj Basu, J. Alan Diehl, Yasuto Uchikado, Koji Tanaka, Yoshiaki Kita, Yuichiro Doki, Adam J. Bass, Ken Sasaki, Hiroshi Nakagawa, Anil K. Rustgi, Kelly A. Whelan, Takeo Hara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thre
Autor:
Timothy Ito, Andres J. Klein-Szanto, Jinfei Xu, Joseph R. Testa, David L. Wiest, Suraj Peri, Eleonora Sementino, Zemin Liu, Yinfei Tan, Kathy Q. Cai, Jianming Pei
Publikováno v:
Oncotarget
// Yinfei Tan 1, * , Eleonora Sementino 1, * , Jinfei Xu 1 , Jianming Pei 1 , Zemin Liu 1 , Timothy K. Ito 1 , Kathy Q. Cai 2 , Suraj Peri 3 , Andres J.P. Klein-Szanto 1, 2 , David L. Wiest 4 , Joseph R. Testa 1 1 Cancer Biology Program, Fox Chase Ca
Autor:
Yuwaraj Kadariya, Andres J. Klein-Szanto, Arti Shukla, Jacqueline Talarchek, Mitchell Cheung, Kathy Q. Cai, Melpo Christofidou-Solomidou, Joseph R. Testa, Craig W. Menges, Ralph A. Pietrofesa, Brooke T. Mossman
Publikováno v:
Cancer Prevention Research. 9:406-414
Exposure to asbestos is causally associated with the development of malignant mesothelioma, a cancer of cells lining the internal body cavities. Malignant mesothelioma is an aggressive cancer resistant to all current therapies. Once inhaled or ingest
Autor:
Craig W. Menges, Mitchell Cheung, Kathy Q. Cai, Andres J. Klein-Szanto, Eleonora Sementino, Frank J. Rauscher, Yuwaraj Kadariya, Jinfei Xu, Joseph R. Testa, Jianming Pei
Publikováno v:
Cancer Research. 76:2836-2844
Individuals harboring inherited heterozygous germline mutations in BAP1 are predisposed to a range of benign and malignant tumor types, including malignant mesothelioma, melanoma, and kidney carcinoma. However, evidence to support a tumor-suppressive
Autor:
Joseph R. Testa, Jacqueline Talarchek, Erin Neumann-Domer, Deborah A. Altomare, Yue Wu, Craig W. Menges, Guang-Hui Xiao, Vihren N. Kolev, Yuwaraj Kadariya, Irina M. Shapiro, Jonathan A. Pachter, Andres J. Klein-Szanto
Publikováno v:
Cancer Research. 74:1261-1271
Malignant mesothelioma is a highly aggressive, asbestos-related cancer frequently marked by mutations of both NF2 and CDKN2A. We demonstrate that germline knockout of one allele of each of these genes causes accelerated onset and progression of asbes
Publikováno v:
Colloquium Series on Protein Activation and Cancer. 1:1-43
Gynecological cancers include neoplasias of internal female genital organs, mainly ovarian, endometrial and cervical tumors, and cancers of the external female genital structures. Current scientific evidence indicates that both up- and down-regulatio
Autor:
Ekaterina G. Shatalova, Andres J. Klein-Szanto, Edna Cukierman, Karthik Devarajan, Margie L. Clapper
Publikováno v:
Cancer Prevention Research. 4:107-115
Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States. The goal of this study was to evaluate the contribution of estrogens to the development of HNSCCs. Various cell lines derived from earl
Autor:
Jonathan Chernoff, Karthik Devarajan, Stephen A. Boorjian, Yan Zhou, Andres J. Klein-Szanto, Igor Makhlin, Christopher J. Long, Jiaru Zhang, Min Huang
Publikováno v:
BJU International. 108:E84-E90
OBJECTIVE To investigate whether mammalian target of rapamycin (mTOR) inhibition by rapamycin is therapeutically efficacious in combination with cisplatin for bladder cancer. MATERIALS AND METHODS Using a panel of human urothelial carcinoma cell line