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Autor:
Shanu Modi
Publikováno v:
Future Oncology. 17:3415-3423
This is a summary of the article discussing the results of the DESTINY-Breast01 study originally published in the New England Journal of Medicine. The DESTINY-Breast01 study is a clinical study in participants with a type of breast cancer called HER2
Autor:
Marilita M Moschos, Konstantinos A A Douglas, Vivian Paraskevi Douglas, Sergios Tsakatikas, Christos Kosmas, Alexandros D Liatsos, Georgios I Papageorgiou, David G Symeonidis
Publikováno v:
Anti-Cancer Drugs. 32:1146-1149
Trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor 2 (Her2) - targeted antibody-drug conjugate that is approved for patients previously treated with trastuzumab and a taxane for Her2-positive advanced breast cancer and those wh
Autor:
Yoann Pointreau, Viorica Braniste, François-Xavier Piloquet, Bérengère Narciso, Antoine Lemaire, Jean-Marc Sabate
Publikováno v:
Supportive Care in Cancer
Purpose Naloxegol, an oral once-daily peripherally acting mu-opioid receptor antagonist, is indicated for the treatment of opioid-induced constipation (OIC) with inadequate response to laxative(s), in cancer and non-cancer patients. This study mainly
Publikováno v:
Clinical & Translational Oncology
Purpose Proper monitoring and management of chemotherapy-induced nausea and vomiting (CINV) with antiemetics is crucial for cancer patients. This study aimed to evaluate the use of antiemetics for the treatment of highly emetogenic chemotherapy (HEC)
Autor:
Yasue Kimura, Eiji Oki, Yoshiaki Fujimoto, Masahito Kotaka, Koji Ando, Hiroyuki Kitao, Yuji Miyamoto, Masaki Mori, Ryota Nakanishi, Shichao Qiu, Yoshihiko Maehara, Mototsugu Shimokawa, Akitaka Makiyama
Publikováno v:
Cancer Science
Trifluridine/tipiracil (FTD/TPI) is an orally administrated anticancer drug with efficacy validated for patients with metastatic colorectal cancer (mCRC) or gastric cancer. FTD, a key component of FTD/TPI, exerts antitumor effects via its incorporati
Autor:
Ke Cong, John J. Krais, Michelle Mosqueda, Sharon B. Cantor, Sumeet Nayak, Lihua Julie Zhu, Jianhong Ou, Min Peng, Matt Bere, Neil Johnson, Samuel M. Bond, Jennifer A. Calvo, Bin Deng, Nicholas J. Panzarino, Mihir B. Doshi
Publikováno v:
Cancer Res
Defects in DNA repair and the protection of stalled DNA replication forks are thought to underlie the chemosensitivity of tumors deficient in the hereditary breast cancer genes BRCA1 and BRCA2 (BRCA). Challenging this assumption are recent findings t
Autor:
Angelika Till, Steffi Busch, Gabriele Kaltenecker, Thomas Resch, Martin Hollaender, Eberhard Müller, Joerg Peter Schilling, Meinholf Karthaus
Publikováno v:
Cancer Research. 81:PS13-35
Background: The primary objective of the prospective, non-interventional study (NIS) AkyPRO was the evaluation of quality of life (QoL) in adult cancer patients (pts) receiving NEPA as antiemetic prophylaxis. Secondary endpoints were efficacy and saf
Autor:
Dexiang Gao, Tessa McSpadden, Sharon Sams, Anthony D. Elias, Virginia F. Borges, Julia Wulfkuhle, Anosheh Afghahi, Emanuel F. Petricoin, Jose I. Mayordomo, Stephanie Armstead, Jennifer R. Diamond, Nicole Spoelsta, Gregory A. Vidal, Elena Shagisultanova, Peter Kabos, Jennifer K. Richer, Lisa Carter, Monica Fournier, Gloria Crawford, Alyse Winchester, Kathryn Zolman
Publikováno v:
Cancer Research. 81:PS12-06
Background: Almost all ER+ breast cancers express androgen receptor (AR), but its function is uncertain. AR expression is associated with more indolent tumors, however high AR expression relative to ER is associated with endocrine resistance, and in
Publikováno v:
Cancer Management and Research
Zixi Chen,* Qiaoli Liu,* Zhaowei Zhu, Fenfen Xiang, Mengzhe Zhang, Rong Wu, Xiangdong Kang Department of Laboratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, People’s Republic of China*These aut
Clinical Complete Response after Chemotherapy and Palliative Surgery for Unresectable Gastric Cancer
Autor:
Kazuhiro Toyota, Yasufumi Saito, Masayuki Shishida, Masahiro Ikeda, Tadateru Takahashi, Nozomi Karakuchi, Masashi Inoue
Publikováno v:
Case Reports in Oncology, Vol 13, Iss 2, Pp 689-695 (2020)
Case Reports in Oncology
Case Reports in Oncology
Gastric cancer incidence is high in several countries, and management of advanced gastric cancer remains a challenge. Chemotherapy for unresectable gastric cancers is still evolving, and achieving a complete cure is difficult. Although a clinical com