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pro vyhledávání: '"11"'
The long non-coding (lnc)RNA cancer susceptibility 11 (CASC11) promotes gastric cancer, however its role in other diseases is unknown. The present study demonstrated upregulation of lncRNA CASC11 and microRNA (miR)-21 in hepatocellular carcinoma (HCC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7318b2cd4bbc0497ee773897b8b443a
https://europepmc.org/articles/PMC7039114/
https://europepmc.org/articles/PMC7039114/
Autor:
Alexa J. Siddon, Thomas Prebet, Scott F. Huntington, Jan Philipp Bewersdorf, Stephanie Halene, Francine M. Foss, Noffar Bar, Natalia Neparidze, Amer M. Zeidan, Rory M. Shallis, Iris Isufi, Terri L. Parker, Nikolai A. Podoltsev, Stuart Seropian, Tae Kon Kim, Manoj M. Pillai, Steven D. Gore, Autumn DiAdamo, Lohith Gowda
Publikováno v:
Blood. 134:5174-5174
Introduction: Isolated trisomy 11 is a rare, poorly characterized cytogenetic abnormality in myeloid neoplasms (MN) with only a few case series published. Prior reports suggested a lower response rate to standard treatments such as intensive chemothe
Autor:
Ann M. Killary, Mei Hu, Raphael E. Pollock, Corazon D. Bucana, Lee M. Ellis, Jonathan C. Trent, Garth L. Nicolson, Aiqing Lang, Lianglin Zhang, Dihua Yu
Publikováno v:
Cancer. 95:1569-1576
BACKGROUND Human sarcomas have a propensity for aggressive local invasion and early pulmonary metastasis. Frequently, deaths are due to uncontrolled pulmonary metastases. The purpose of the current study was to evaluate cytogenetics, tumorigenicity,
Publikováno v:
BJU International. 85:864-868
Objective To describe the incidence, clinical characteristics, treatment methods and long-term follow-up of bilateral germ cell tumours of the testis (GCTT) in patients treated at one institution. Patients and methods Of 552 patients with GCTT, 11 (2
Publikováno v:
Archives of Otolaryngology - Head and Neck Surgery. 122:1404-1408
A 47-year-old man with a history of a benign papilloma of the tongue 5 years earlier was treated for a squamous cell carcinoma of the tongue with surgical resection. An analysis of the tumor DNA using several methods showed the presence of human papi
Autor:
Antonio Ramos-Montoya, Timothy J. Larkin, David Y. Lewis, Kevin M. Brindle, Robert Bielik, David E. Neal, Joan Boren, Dmitry Soloviev, Greg Shaw, Carla P. Martins
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 55(7)
Tumors are often characterized by high levels of de novo fatty acid synthesis. The kinetics of acetate incorporation into tricarboxylic acid cycle intermediates and into lipids suggest that detection of tumors with [1-11C]acetate PET could be improve
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
strongBACKGROUND/strongThis study aimed to explain the effects and mechanism of MT1JP in lung cancer development and treatment.strongMATERIAL AND METHODS/strongThirty non-small cell lung cancer (NSCLC) (stages I-II, 17 cases; stages III-IV, 13 cases)
Autor:
Benjamin G. Neel, Mitchell J. Geer, Kwok-Kin Wong, Brian Diskin, Takamitsu Hattori, Paolo Mita, Kai Wen Teng, Connor Foster, Joshua Leinwand, Carmine Fedele, Akiko Koide, Ting Chen, Wei Wang, Shohei Koide, Shuai Li, Kwan Ho Tang, Yubao Wang, David H. Peng, Jiehui Deng, Hao Ran, Igor Dolgalev, George Miller, Ugur Ozerdem
Publikováno v:
The Journal of Experimental Medicine
G12C inhibitors (G12C-Is) have significant but limited efficacy in KRAS-mutant malignancies, mostly due to “adaptive resistance.” Combining SHP2 inhibitor (SHP2-I) with G12C-I abrogates adaptive resistance; evokes beneficial, tumor-specific chang
Autor:
Jingjing Xie, Xiaojia Si, Shoulai Gu, Mingliang Wang, Jian Shen, Haoyan Li, Dan Li, Yanjia Fang, Cong Liu, Jidong Zhu
Publikováno v:
Journal of medicinal chemistry. 60(24)
SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways. SHP2 has been shown to contribute to the progression of a number of cancer types
Autor:
Wadih Arap, Amado J. Zurita, Patricia Troncoso, Christopher J. Logothetis, Renata Pasqualini, Marina Cardó-Vila
Publikováno v:
Cancer Research. 64:435-439
Direct screening of combinatorial peptide libraries in patients may allow the identification of ligands that target biochemical differences in the endothelium of blood vessels. In a screening performed in a patient, we selected and isolated a mimic m