Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Wendie N. Marks"'
Publikováno v:
Behavioural Brain Research. 361:54-64
Abnormalities in social behavior are a co-morbid symptom of idiopathic generalized epilepsies such as childhood absence epilepsy. The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model is a spontaneously occurring absence epilepsy phenotype
Autor:
Terrance P. Snutch, Quentin Greba, Wendie N. Marks, Nadine K. Zabder, Madeline E. Parker, John G. Howland
Publikováno v:
Learning & Memory. 25:317-324
The roles of low-voltage-activated (T-type) calcium channels in brain diseases have been studied extensively. Less is known regarding the involvement of T-type channels in cognition and behavior. Sensory integration (SI) is a cognitive process whereb
Publikováno v:
Neurobiology of Disease, Vol 94, Iss, Pp 106-115 (2016)
Childhood absence epilepsy (CAE) is often comorbid with behavioral and cognitive symptoms, including impaired visual memory. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is an animal model closely resembling CAE; however, cognition in GAERS
Publikováno v:
Neuroscience. 332:121-129
The role of T-type calcium channels in brain diseases such as absence epilepsy and neuropathic pain has been studied extensively. However, less is known regarding the involvement of T-type channels in cognition and behavior. Prepulse inhibition (PPI)
Autor:
John G. Howland, Stuart M. Cain, Terrance P. Snutch, Quentin Greba, Wendie N. Marks, Nadine K. Zabder
Publikováno v:
The European journal of neuroscienceREFERENCES. 50(6)
Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are a rodent model of childhood absence epilepsy (CAE) that display a gain-of-function mutation in the gene encoding the Cav3.2 T-type calcium channel. GAERS demonstrate heightened learning and de
T-type calcium channels regulate the acquisition and recall of conditioned fear in male, Wistar rats
Publikováno v:
Behavioural Brain Research. 393:112747
The T-type calcium channel blocker, Z944, has been used as a pharmacological tool to assess T-type calcium channel function and examined for use as an anti-epileptic. As Z944 affects fear learning and memory in a rodent model of absence epilepsy, it
Autor:
Terrance P. Snutch, Wendie N. Marks, John G. Howland, Nadine K. Zabder, Nimra B. Tahir, Max C. Liu, Andrew J. Roebuck
Publikováno v:
Psychopharmacology. 235(11)
Currently available antipsychotics are unsatisfactory given their side effects and limited efficacy for the cognitive symptoms of schizophrenia. Many currently available drugs, such as haloperidol, are T-type calcium channel antagonists in addition t
Autor:
Madeline J. Collins, Wendie N. Marks, Mark T. Henbid, Terrance P. Snutch, Stuart M. Cain, John G. Howland
Publikováno v:
Experimental neurology. 296
Childhood absence epilepsy (CAE) is associated with interictal co-morbid symptoms including abnormalities in social behaviour. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is a model of CAE that exhibits physiological and behavioural alterat