Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Maike, Bublitz"'
Autor:
Maike Bublitz, William Dalby-Brown, Franco Aversa, Paolo Sportoletti, Anne-Marie Lund Winther, Marilena Baglione, Giorgia Rastelli, Chiara Rompietti, Rocchina Vilella, Donatella Stilli, Caterina Loiacono, Federica Rizzi, Samuel Kitara, Luca Pagliaro, Giovanni Roti, Andrea Gherli, Claus Olesen, Anna Montanaro, Roberta La Starza, Monia Savi, Matteo Marchesini, Leonardo Bocchi, Cristina Mecucci, Laura Patrizi, Sabine Heit, Claudia Sorrentino, Jesper V. Møller, Kimberly Stegmaier
Publikováno v:
Cell Chem Biol
Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, C E, Møller, J V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A M, Sportoletti, P, Bublitz, M, Dalby-Brown, W & Roti, G 2020, ' Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia ', Cell Chemical Biology, vol. 27, no. 6, pp. 678-697.e13 . https://doi.org/10.1016/j.chembiol.2020.04.002
Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, C E, Møller, J V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A M, Sportoletti, P, Bublitz, M, Dalby-Brown, W & Roti, G 2020, ' Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia ', Cell Chemical Biology, vol. 27, no. 6, pp. 678-697.e13 . https://doi.org/10.1016/j.chembiol.2020.04.002
The identification of SERCA (sarco/endoplasmic reticulum calcium ATPase) as a target for modulating gain-of-function NOTCH1 mutations in Notch-dependent cancers has spurred the development of this compound class for cancer therapeutics. Despite the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e63576c860546d9cf10c8571266edb
https://doi.org/10.1016/j.chembiol.2020.04.002
https://doi.org/10.1016/j.chembiol.2020.04.002
Autor:
Paulette Decottignies, Marc le Maire, Cédric Montigny, Jesper V. Møller, Pierre Le Maréchal, Pierre Capy, Claus Olesen, Poul Nissen, Maike Bublitz
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (49), pp.33850-61. ⟨10.1074/jbc.M114.590307⟩
Montigny, C, Decottignies, P, le Maréchal, P, Capy, P, Bublitz, M, Olesen, C, Møller, J V, le Maire, M & Nissen, P 2014, ' S-Palmitoylation and S-Oleoylation of Rabbit and Pig Sarcolipin ', Journal of Biological Chemistry, vol. 289, pp. 33850-33861 . https://doi.org/10.1074/jbc.M114.590307
Journal of Biological Chemistry, 2014, 289 (49), pp.33850-61. ⟨10.1074/jbc.M114.590307⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (49), pp.33850-61. ⟨10.1074/jbc.M114.590307⟩
Montigny, C, Decottignies, P, le Maréchal, P, Capy, P, Bublitz, M, Olesen, C, Møller, J V, le Maire, M & Nissen, P 2014, ' S-Palmitoylation and S-Oleoylation of Rabbit and Pig Sarcolipin ', Journal of Biological Chemistry, vol. 289, pp. 33850-33861 . https://doi.org/10.1074/jbc.M114.590307
Journal of Biological Chemistry, 2014, 289 (49), pp.33850-61. ⟨10.1074/jbc.M114.590307⟩
International audience; Sarcolipin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of animals. We find that native rabbit SLN is modified by a fatty acid anchor on Cys-9 with a palmitic acid in about 60% and,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e559e276fe961f69bd7509f43b28ed9e
https://hal.archives-ouvertes.fr/hal-01179260
https://hal.archives-ouvertes.fr/hal-01179260
Autor:
Maike Bublitz, Poul Nissen, Ditte F. Bonde, Ingrid Dach, Eleonora Tenori, Jesper V. Møller, Henriette Elisabeth Autzen, S. Brøgger Christensen, Pankaj Sehgal, Mette Alstrup Lie, Jesper Villadsen, Eleonora S. Paulsen, Claus Olesen, Birgit Schiøtt, Huizhen Liu
Publikováno v:
Paulsen, E S, Villadsen, J, Tenori, E, Liu, H, Bonde, D F, Lie, M A, Bublitz, M, Olesen, C, Autzen, H E, Dach, I, Sehgal, P, Nissen, P, Møller, J V, Schiøtt, B & Christensen, SB 2013, ' Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase ', Journal of Medicinal Chemistry, vol. 56, no. 9, pp. 3609-3619 . https://doi.org/10.1021/jm4001083
A crystal structure suggests four water molecules are present in the binding cavity of thapsigargin in sarco/endoplasmic reticulum calcium ATPase (SERCA). Computational chemistry indicates that three of these water molecules mediate an extensive hydr
Autor:
Birgit Schiøtt, Lea Thøgersen, Maria Musgaard, Poul Nissen, Jesper V. Møller, J. Preben Morth, Claus Olesen, Maike Bublitz, Hanne Poulsen
Publikováno v:
Bublitz, M, Musgaard, M, Poulsen, H, Thøgersen, L, Olesen, C, Schiøtt, B, Morth, P, Møller, J V & Nissen, P 2013, ' Ion Pathways in the Sarcoplasmic Reticulum Ca 2+-ATPase ', Journal of Biological Chemistry, vol. 288, pp. 10759-10765 . https://doi.org/10.1074/jbc.R112.436550
The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) is a transmembrane ion transporter belonging to the P(II)-type ATPase family. It performs the vital task of re-sequestering cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby als