Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Stephen R. Bloom"'
Autor:
Victoria Salem, Lysia Demetriou, Kleopatra Alexiadou, Tricia Tan, Alexander D. Miras, Waljit S. Dhillo, Preeshila Behary, Matthew B. Wall, Ahmed R. Ahmed, Sanjay Purkayastha, Stephen R. Bloom, George Tharakan, Samantha Scholtz
Publikováno v:
Diabetes Care
OBJECTIVE Weight loss achieved with very-low-calorie diets (VLCDs) can produce remission of type 2 diabetes (T2D), but weight regain very often occurs with reintroduction of higher calorie intakes. In contrast, bariatric surgery produces clinically s
Autor:
Uma Anand, Barbara Pacchetti, Stephen R. Bloom, Praveen Anand, Mikael H. Sodergren, Yuri E. Korchev, Ben Jones
Publikováno v:
Journal of Pain Research. 13:2269-2278
Introduction Cannabidiol (CBD) is reported to produce pain relief, but the clinically relevant cellular and molecular mechanisms remain uncertain. The TRPV1 receptor integrates noxious stimuli and plays a key role in pain signaling. Hence, we conduct
Autor:
Kerstin Stemmer, Stephen C. Woods, Harvey J. Grill, Jens J. Holst, Alessandro Pocai, Michael A. Nauck, Andreas Fritsche, Richard D. DiMarchi, David A. D'Alessio, Mads Tang-Christensen, Diego Perez-Tilve, Darleen A. Sandoval, Randy J. Seeley, Wolfgang Langhans, Daniel J. Drucker, Stephen R. Bloom, M.H. Tschöp, Brian Finan, Fiona M. Gribble, Timo D. Müller, Peter R. Flatt, Joel F. Habener, Juris J. Meier, Thue W. Schwartz, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 30, Iss, Pp 72-130 (2019)
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010
Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, in
Autor:
Jia V. Li, James Minnion, Kleopatra Alexiadou, George Tharakan, Ahmed R. Ahmed, Stephen R. Bloom, Matthew R. Lewis, Preeshila Behary, Sanjay Purkayastha, Ben Jones, Tricia Tan, Caroline Sands
Publikováno v:
e782
e767
The Journal of Clinical Endocrinology and Metabolism
e767
The Journal of Clinical Endocrinology and Metabolism
Context The gut-derived peptide hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY) are regulators of energy intake and glucose homeostasis and are thought to contribute to the glucose-lowering effects of bariatric sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79846c6772014111d5d75a84f56ac136
http://hdl.handle.net/10044/1/91275
http://hdl.handle.net/10044/1/91275
Autor:
Sherif Hakky, George Tharakan, Julia Kenkre, Ibiyemi Ilesanmi, Khalefah Malallah, Preeshila Behary, Kleopatra Alexiadou, Sirazum Choudhury, Yasmin Tabbakh, Stephen R. Bloom, Sanjay Purkayastha, Ahmed R. Ahmed, Christos Tsironis, Tricia Tan
Publikováno v:
Obesity Abstracts.
Publikováno v:
Expert Opinion on Drug Discovery. 14:1151-1159
Introduction: Obesity is a global pandemic and new pharmacotherapies which combine weight loss efficacy, long-term safety, and reversal of metabolic co-morbidities are sorely needed. Gut hormones p...
Autor:
Madhawi Aldhwayan, Stephen R. Bloom, Werd Al-Najim, Belén Pérez-Pevida, Aviva Petrie, Omar A. Khan, Ahmed R. Ahmed, Veronica Greener, Barbara McGowan, Alexander D. Miras, Harvinder Chahal, Samantha Scholtz, Tricia Tan, Anna Kamocka, Emma Rose McGlone, Rachel L. Batterham
Publikováno v:
The Lancet Diabetes & Endocrinology. 7:549-559
Summary Background Many patients with type 2 diabetes do not achieve sustained diabetes remission after metabolic (bariatric) surgery for the treatment of obesity. Liraglutide, a glucagon-like peptide-1 analogue, improves glycaemic control and reduce
Autor:
Bernard Khoo, Francesca Fiorentino, Tricia Tan, Laura-Jayne Ball, Charlie Brindley, James Minnion, Reshma Malviya, Emily Day, Stephen R. Bloom, Jim Bush
Publikováno v:
Tan, T M-M, Minnion, J, Khoo, B, Ball, L-J, Malviya, R, Day, E, Fiorentino, F, Brindley, C, Bush, J & Bloom, S R 2021, ' Safety and efficacy of an extended-release peptide YY analogue for obesity : A randomized, placebo-controlled, phase 1 trial ', Diabetes, obesity & metabolism, vol. 23, no. 7, pp. 1471-1483 . https://doi.org/10.1111/dom.14358
AIM: To report the results from a Phase 1 trial of an extended-release peptide YY analogue, Y14, developed for the treatment of obesity.METHODS: Y14 was evaluated in overweight/obese volunteers in a Phase 1 randomized placebo-controlled trial, conduc
Autor:
Emily Day, Reshma Malviya, Stephen R. Bloom, Francesca Fiorentino, Charlie Brindley, Jim Bush, Laura-Jayne Ball, Tricia Tan, James Minnion, Bernard Khoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a29bc1c3f274b4d2158069c17102996
https://doi.org/10.1111/dom.14358/v2/response1
https://doi.org/10.1111/dom.14358/v2/response1
Autor:
Ahmed R. Ahmed, Julia Kenkre, Tricia Tan, Sanjay Purkayastha, Stephen R. Bloom, A Toby Prevost, Khalefah Malallah, Alexandra I. F. Blakemore
Publikováno v:
BMJ Open
BMJ Open, Vol 11, Iss 2 (2021)
BMJ Open, Vol 11, Iss 2 (2021)
IntroductionType 2 diabetes mellitus (T2DM) and obesity are pandemic diseases that lead to a great deal of morbidity and mortality. The most effective treatment for obesity and T2DM is bariatric or metabolic surgery; it can lead to long-term diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abc9d30f398fec849d01c62865da08d
http://hdl.handle.net/10044/1/87213
http://hdl.handle.net/10044/1/87213