Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Malcolm J. Moore"'
Autor:
Dongsheng Tu, Timothy J. Price, Hagen F. Kennecke, Daniel L. Edelstein, Scott Kopetz, Frank Holtrup, Hannah Quinn, Anthony Dowers, Stanley R. Hamilton, Derek J. Jonker, John Zalcberg, Christos S Karapetis, Paul Waring, Jonathan M. Loree, Christopher J. O'Callaghan, Malcolm J. Moore
Publikováno v:
Clinical Cancer Research. 27:52-59
Purpose: Expanded RAS/BRAF mutations have not been assessed as predictive for single-agent cetuximab in metastatic colorectal cancer (mCRC), and low mutant allele frequency (MAF) mutations are of unclear significance. We aimed to establish cetuximab
Autor:
Gun Ho Jang, Michael K.C. Lee, Steven J.M. Jones, Richard A. Moore, Janessa Laskin, Joanna M. Karasinska, James T. Topham, Robert E. Denroche, Malcolm J. Moore, Laura Williamson, Steve E. Kalloger, Grainne M. O'Kane, Jennifer J. Knox, Cassia Warren, Daniel J. Renouf, Hui-Li Wong, Faiyaz Notta, Andrew J. Mungall, Marco A. Marra, Luka Culibrk, Andrew Metcalfe, David F. Schaeffer, Steven Gallinger
Publikováno v:
Clinical Cancer Research. 26:135-146
Purpose: Identification of clinically actionable molecular subtypes of pancreatic ductal adenocarcinoma (PDAC) is key to improving patient outcome. Intertumoral metabolic heterogeneity contributes to cancer survival and the balance between distinct m
Autor:
Qian Shi, Jeffrey A. Meyerhardt, Mitchell C. Posner, Vikram Deshpande, Douglas B. Evans, Laura W. Goff, Nipun B. Merchant, Eileen M. O'Reilly, Xiomara W. Carrero, Hedy L. Kindler, Peter W.T. Pisters, Malcolm J. Moore, Elliot Newman, Alice C. Wei, Joseph Misdraji, Jordan Berlin, Fang-Shu Ou, Eric P. Tamm, Dushyant V. Sahani, Robert A. Wolff
Publikováno v:
Ann Surg Oncol
BACKGROUND: There is considerable interest in a neoadjuvant approach for resectable pancreatic ductal adenocarcinoma (PDAC). This study evaluated perioperative gemcitabine + erlotinib (G+E) for resectable PDAC. METHODS: A multicenter, cooperative gro
Autor:
Janessa Laskin, Sharlene Gill, Jennifer J. Knox, David F. Schaeffer, Martin R. Jones, Marco A. Marra, Howard John Lim, Daniel J. Renouf, James T. Topham, Steven Gallinger, Hui-Li Wong, Karen Mungall, Julie Ho, Richard A. Moore, Angela Goytain, Malcolm J. Moore, Steven J.M. Jones, Yussanne Ma, Andrew J. Mungall, Laura Williamson, Wei Zhang, Robert E. Denroche, Yaoquing Shen, Michael K.C. Lee, Erin Pleasance, Sara Sadeghi, Gun-Ho Jang, Stephen Yip, Joanna M. Karasinska, Carolyn Reisle, Tony Ng, John Paul McGhie
Publikováno v:
Clinical Cancer Research. 25:4674-4681
Purpose: Gene fusions involving neuregulin 1 (NRG1) have been noted in multiple cancer types and have potential therapeutic implications. Although varying results have been reported in other cancer types, the efficacy of the HER-family kinase inhibit
Autor:
Steven Gallinger, Maja Segedi, Ayelet Borgida, Martin O'Malley, Pablo E. Serrano, Neesha C. Dhani, Malcolm J. Moore, Alice C. Wei, Benjamin Loveday, Carol-Anne Moulton, Amélie Tremblay, Teresa Bianco, Sean Creighton, Nathan Zilbert, Adriana Fraser, Ian D. McGilvray, John Kim, Sean P. Cleary, Adrian Fox, Anna Dodd, Koji Tomiyama, Paul D. Greig
Publikováno v:
HPB. 21:643-652
Background Stage 3 pancreatic ductal adenocarcinoma (PDAC) is defined by arterial involvement. This study objective was to evaluate outcomes for patients with stage 3 PDAC with potentially reconstructable arterial involvement, considered for neoadjuv
Autor:
Malcolm J. Moore, Stefano Serra, Tracy Stockley, Amit M. Oza, Philippe L. Bedard, Kyaw L. Aung, Amanda Giesler, Tong Zhang, Mahadeo A. Sukhai, Lillian L. Siu, John Douglas Mcpherson, Hal K. Berman, Aaron R. Hansen, Eitan Amir, Anthony M. Joshua, Lailah Ahmed, Scott Boerner, Sangeet Ghai, Celeste Yu, Philip C. Zuzarte, Suzanne Kamel-Reid
Publikováno v:
JCO Precision Oncology. :1-20
Purpose Fine-needle biopsy (FNB) and liquid biopsy are minimally invasive methods of tumor sampling that provide feasible means to assess tumor genotypes in real time. However, more data are needed to establish the strength of these methods by benchm
Autor:
Julie Tsao, Laleh Soltan Ghoraie, Lynn Anson-Cartwright, Aaron R. Hansen, Jeremy Lewin, Neil Winegarden, Philippe L. Bedard, Malcolm J. Moore, Robert J. Hamilton, Michael A.S. Jewett, Peter Chung, Carl Virtanen, Padraig Warde, Benjamin Haibe-Kains, Joan Sweet
Publikováno v:
BJU International. 122:814-822
Objectives To identify differentially expressed genes between relapsed and non-relapsed clinical stage I testicular germ cell tumours (TGCTs). Materials and methods We reviewed patients with clinical stage I non-seminoma and seminoma from an institut
Autor:
Ben Tran, Peter Chung, Lynn Anson-Cartwright, Eitan Amir, Malcolm J. Moore, Jeremy Sturgeon, Edmond M. Kwan, Padraig Warde, Philippe L. Bedard, Sophie Beck, Michael A.S. Jewett
Publikováno v:
Clinical Genitourinary Cancer. 16:e193-e199
Objective To examine the impact of granulocyte-colony stimulating factor (G-CSF) use on the incidence and severity of bleomycin-induced pneumonitis (BIP) in patients with germ cell tumor (GCT) receiving first-line chemotherapy. Patients and Methods C
Autor:
Richard K. G. Do, David P. Kelsen, Eileen M. O'Reilly, Michal Segal, Amiel Segal, Zsofia K. Stadler, Laura H. Tang, Talia Golan, Erin E. Salo-Mullen, Neesha C. Dhani, Alice P. Chen, Hannah Maynard, Marinela Capanu, Robin Brenner, Andrew S. Epstein, Maeve A. Lowery, Hayley Estrella, Jonathan W. Lee, Hedy L. Kindler, Malcolm J. Moore, Kenneth H. Yu
Publikováno v:
Cancer. 124:1374-1382
Background A phase 1 trial was used to evaluate a combination of cisplatin, gemcitabine, and escalating doses of veliparib in patients with untreated advanced pancreatic ductal adenocarcinoma (PDAC) in 2 cohorts: a germline BRCA1/2-mutated (BRCA+) co
Autor:
S. Lawrence Librach, Malcolm J. Moore, Kenneth Mah, Kim T. Tran, David Warr, Camilla Zimmermann, Frances A. Shepherd, Gary Rodin, Lynn R. Gauthier, Lucia Gagliese
Publikováno v:
The Journal of Pain. 18:811-824
Pain-related stoicism and cautiousness are theorized to be more prevalent in older than younger patients and to lead to greater pain under-reporting and consequently inadequate pain management in older patients. The Pain Attitudes Questionnaire-Revis