Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Kees Hovingh"'
Autor:
Linda Zuurbier, Amand F. Schmidt, Arjen J. Cupido, Erik S.G. Stroes, Joep C. Defesche, Laurens F. Reeskamp, G. Kees Hovingh, Tycho R Tromp
Publikováno v:
Atherosclerosis, 340, 61-67. Elsevier Ireland Ltd
BACKGROUND AND AIMS: Low-density lipoprotein cholesterol (LDL-C) levels vary in patients with familial hypercholesterolemia (FH) and can be explained by a single deleterious genetic variant or by the aggregate effect of multiple, common small-effect
Autor:
G. Kees Hovingh, Larry Lo, Mads D M Engelmann, Paul M. Ridker, Pablo Pergola, Florian M.M. Baeres, Peter Libby, Rescue Investigators, Milana Ivkovic, Michael H. Davidson, Matt Devalaraja, Dominic S. Raj, Douglas Kling
Publikováno v:
The Lancet, 397(10289), 2060-2069. Elsevier Limited
Background: IL-6 has emerged as a pivotal factor in atherothrombosis. Yet, the safety and efficacy of IL-6 inhibition among individuals at high atherosclerotic risk but without a systemic inflammatory disorder is unknown. We therefore addressed wheth
Publikováno v:
Current Opinion in Lipidology
Current opinion in lipidology, 32(2), 112-116. Lippincott Williams and Wilkins
Current opinion in lipidology, 32(2), 112-116. Lippincott Williams and Wilkins
Purpose of review The current review describes the development, clinical relevance and potential caveats of polygenic risk scores (PRS) for LDL cholesterol (LDL-C). Recent findings In recent years, a large number of common variants have been shown to
Autor:
Roeland Huijgen, G. Kees Hovingh, Erik S.G. Stroes, Laurens F. Reeskamp, Aldo Grefhorst, Tycho R Tromp
Publikováno v:
Atherosclerosis, 315, 68-75. Elsevier Ireland Ltd
Background and aims: Statins suppress hepatic mRNA expression of ANGPTL3 encoding angiopoietin-like 3 in healthy subjects, but it is unknown if plasma ANGPTL3 concentrations are affected by statins prescribed to hypercholesterolemic patients in clini
Autor:
Mariette Lengquist, Mathilde Frederikke Bjørn Bonde, G. Kees Hovingh, Heidi Engslev Lund, Bidda Rolin, Stefan Zahn, Michael Nyberg, Karin Hultman, Lars Maegdefessel, Valentina Manfè, Pernille Gry Wulff-Larsen, Karin Conde-Knape, Ulf Hedin, Djordje Djordjevic, Rikke Kaae Kirk, Ljubica Perisic Matic, Niels Blume, Günaj Rakipovski, Maj Petersen, Natasha Barascuk
Publikováno v:
Atherosclerosis, 314, 1-9. Elsevier Ireland Ltd
Background and aims Clinical interventions targeting nonlipid risk factors are needed given the high residual risk of atherothrombotic events despite effective control of dyslipidemia. Dickkopf-1 (DKK1) plays a lipid-independent role in vascular path
Autor:
Helen M. Colhoun, Scott S. Emerson, Steve Marso, G. Kees Hovingh, Kirstine Brown-Frandsen, Steven E. Kahn, John E. Deanfield, Robert F. Kushner, A. Michael Lincoff, Henrik Ravn, Jorge Plutzky, Ildiko Lingvay, Donna H. Ryan, Anders G. Holst, Marianne O. L. Gronning
Publikováno v:
American heart journal, 229, 61-69. Mosby Inc.
Ryan, D H, Lingvay, I, Colhoun, H M, Deanfield, J, Emerson, S S, Kahn, S E, Kushner, R F, Marso, S, Plutzky, J, Brown-Frandsen, K, Gronning, M O L, Hovingh, G K, Holst, A G, Ravn, H & Lincoff, A M 2020, ' Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design ', American Heart Journal, vol. 229, pp. 61-69 . https://doi.org/10.1016/j.ahj.2020.07.008
Ryan, D H, Lingvay, I, Colhoun, H M, Deanfield, J, Emerson, S S, Kahn, S E, Kushner, R F, Marso, S, Plutzky, J, Brown-Frandsen, K, Gronning, M O L, Hovingh, G K, Holst, A G, Ravn, H & Lincoff, A M 2020, ' Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design ', American Heart Journal, vol. 229, pp. 61-69 . https://doi.org/10.1016/j.ahj.2020.07.008
Cardiovascular disease (CVD) is a major cause of morbidity and mortality. Although it has been widely appreciated that obesity is a major risk factor for CVD, treatments that produce effective, durable weight loss and the impact of weight reduction i
Autor:
Arjen J. Cupido, Marjolein A.W. van den Boogert, Maaike Rijkers, G. Kees Hovingh, Geesje M. Dallinga-Thie, Lubna Ali, Adriaan G. Holleboom, Erik S.G. Stroes
Publikováno v:
Atherosclerosis, 306, 15-21. Elsevier Ireland Ltd
Background and aims The rare ASGR1 del12 variant is associated with a beneficial effect on coronary artery disease (CAD) that is disproportionate to the small reductions in plasma LDL cholesterol (LDLc). This unexplained benefit has sparked the debat
Autor:
Gisle Langslet, Alexia Letierce, Marie T. Baccara-Dinet, Garen Manvelian, G. Kees Hovingh, Michel Farnier, John R. Guyton
Publikováno v:
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, 34(4), 515-523. Kluwer Academic Publishers
Cardiovascular Drugs and Therapy
Cardiovascular Drugs and Therapy
PurposeDuring the alirocumab open-label extension study ODYSSEY OLE (open-label extension; NCT01954394), physicians could adjust alirocumab dosing for enrolled patients, who were diagnosed with heterozygous familial hypercholesterolemia (HeFH) and wh
Autor:
G. Kees Hovingh, Caroline S. Bruikman, Julian C. van Capelleveen, Geesje M. Dallinga-Thie, Laurens C. Huisman, Onno J. de Boer, Anne Tybjærg-Hansen, Jorge Peter, Martine C.M. Willems, Jeffrey Kroon, N. Dalila, Stefan R. Havik
Publikováno v:
Journal of clinical lipidology, 14(4), 470-481. Elsevier BV
Background Genetic factors partly determine the risk for premature myocardial infarction (MI). Objectives We report the identification of a novel rare genetic variant in a kindred with an autosomal dominant trait for premature MI and atherosclerosis
Publikováno v:
Expert opinion on investigational drugs. 29(5):483-493
Introduction: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. High plasma low-density lipoprotein cholesterol (LDL-C) levels are a key CVD-risk factor. Triglyceride-rich remnant particles and lipoprotein(a) (Lp[a]) are als