Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Glenn Dranoff"'
Autor:
Carol Reynolds, Joseph H. Antin, Mariano Severgnini, Corey Cutler, David Avigan, Jacalyn Rosenblatt, Glenn Dranoff, Ilene Galinsky, Augustine Weber, Olga Pozdnyakova, Yi-Bin Chen, Vincent T. Ho, Haesook T. Kim, Sarah Nikiforow, Jerome Ritz, Robert J. Soiffer, Jennifer Brock, Mahasweta Gooptu, Edwin P Alyea, Heather Daley, John Koreth, F. Stephen Hodi, Roman M Shapiro, Catherine J. Wu, Rizwan Romee
Publikováno v:
Blood advances. 6(7)
Vaccination using irradiated, adenovirus transduced autologous myeloblasts to secrete granulocyte–macrophage colony-stimulating factor (GVAX) early after allogeneic hematopoietic stem cell transplantation (HSCT) can induce potent immune responses.
Publikováno v:
Annual Review of Cancer Biology. 3:55-75
Blocking antibodies to the immune checkpoint receptors or their ligands have revolutionized the treatment of diverse malignancies. Many tumors are recognized by adaptive immunity, but these adaptive responses can be inhibited by immunosuppressive mec
Autor:
Xiuyu Cui, Amber J. Giles, Christina Jackson, Tanner M. Johanns, Luis Sanchez-Perez, Karolina Woroniecka, Kristen E. Rhodin, Gavin P. Dunn, Hanna Kemeny, Vidyalakshmi Chandramohan, Patrick Healy, S. Harrison Farber, Glenn Dranoff, Aladine A. Elsamadicy, Shohei Koyama, Kent J. Weinhold, Pakawat Chongsathidkiet, Darell D. Bigner, Cosette Dechant, Yen-Rei A. Yu, Landon J. Hansen, Peter E. Fecci
Publikováno v:
Clinical Cancer Research. 24:4175-4186
Purpose: T-cell dysfunction is a hallmark of glioblastoma (GBM). Although anergy and tolerance have been well characterized, T-cell exhaustion remains relatively unexplored. Exhaustion, characterized in part by the upregulation of multiple immune che
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
Autor:
Karolina Woroniecka, Jeffrey I. Everitt, Peter E. Fecci, Hanna Kemeny, Robert L. Martuza, John H. Sampson, James E. Herndon, Tooba A. Cheema, Christina Jackson, William T. Curry, Pakawat Chongsathidkiet, Xiuyu Cui, Nicholas C. Souders, Cosette Dechant, Brian V. Nahed, Michael D. Gunn, Shohei Koyama, Franziska Loebel, Glenn Dranoff, Jean-Valery Coumans, Aladine A. Elsamadicy, S. Harrison Farber, Luis Sanchez-Perez
Publikováno v:
Nature medicine
T-cell dysfunction contributes to tumor immune escape in patients with cancer and is particularly severe amidst glioblastoma (GBM). Among other defects, T-cell lymphopenia is characteristic, yet often attributed to treatment. We reveal that even trea
Autor:
Anne-Sophie Wavreille, Shumei Qiu, Viviana Cremasco, Glenn Dranoff, Xiaomo Jiang, Melanie Verneret, Mikael L. Rinne, Nidhi Patel, Hongbo Lu, Fiona Sharp, Catherine Anne Sabatos-Peyton, Pushpa Jayaraman, Stephanie Schwartz, Lisa Baker, Tyler Longmire
Publikováno v:
Regular and young investigator award abstracts.
Background TIM-3 is expressed on leukemic stem cells (LSCs) and blasts in AML,1 2 and TIM-3 expression on MDS blasts correlates with disease progression.3 Functional evidence for TIM-3 in AML was established with an anti-TIM-3 antibody which inhibite
Autor:
Lina Driouk, Joanina K. Gicobi, Yusuke Kamihara, Kayleigh Rutherford, Glenn Dranoff, Jerome Ritz, Susanne H. C. Baumeister
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
CAR T cell approaches to effectively target AML and T-ALL without off-tumor effects on healthy myeloid or T cell compartments respectively are an unmet medical need. NKG2D-ligands are a promising target given their absence on healthy cells and surfac
Autor:
Glenn Dranoff, Isaac H. Solomon, Rebecca A. Betensky, Jerome Ritz, Mark W. Kieran, Pratiti Bandopadhayay, Keith L. Ligon, Ashley S. Plant, Ryan O. Emerson, Shohei Koyama, Claire Sinai, Gabriel K. Griffin
Publikováno v:
Journal of Neuro-Oncology. 137:269-278
There is little known regarding the immune infiltrate present in pediatric brain tumors and how this compares to what is known about histologically similar adult tumors and its correlation with survival. Here, we provide a descriptive analysis of the
Autor:
Mark A. Exley, Anita Giobbie-Hurder, Steven P. Balk, Yo Mizukami, Tetsuro Sasada, Jerome Ritz, Lianne E.M. Vriend, Kenneth LeClair, F. Stephen Hodi, Heather Daley, Glenn Dranoff, Christine Canning, Phillip Friedlander, Wanyong Zeng, David M. Nemer, Nadia Alatrakchi, Simon Yue, Justice Clark
Publikováno v:
Clinical Cancer Research. 23:3510-3519
Purpose: Invariant NKT cells (iNKT) are innate-like CD1d-restricted T cells with immunoregulatory activity in diseases including cancer. iNKT from advanced cancer patients can have reversible defects including IFNγ production, and iNKT IFNγ product
Autor:
Jingjing Li, George F. Murphy, Margaret A. Shipp, David F. McDermott, Anita Giobbie-Hurder, Xiaoyun Liao, Glenn Dranoff, Matthias Piesche, Scott J. Rodig, Jing Ouyang, Erin M. Connolly, Xinqi Wu, F. Stephen Hodi, Donald P. Lawrence, Jun Zhou
Publikováno v:
Cancer Immunology Research. 5:446-454
The combination of anti-VEGF blockade (bevacizumab) with immune checkpoint anti–CTLA-4 blockade (ipilimumab) in a phase I study showed tumor endothelial activation and immune cell infiltration that were associated with favorable clinical outcomes i
Autor:
Lauren Eastman, Michael Manos, Scott J. Rodig, Jingjing Li, F. Stephen Hodi, Jun Zhou, Xinqi Wu, Kathleen M. Mahoney, Fengmin Zhao, Xiaoyun Liao, Lisa H. Butterfield, Anita Giobbie-Hurder, Sandra J. Lee, Matthias Piesche, Glenn Dranoff, Gordon J. Freeman
Publikováno v:
Cancer Immunology Research. 5:480-492
Blockade of the pathway including programmed death-ligand 1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) has produced clinical benefits in patients with a variety of cancers. Elevated levels of soluble PD-L1 (sPD-L1) have been asso