Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Eckhard Wolf"'
Publikováno v:
European Journal of Endocrinology. 185:R35-R47
The aim of the study is to find possible explanations for vanishing juvenile hypoglycemia in growth hormone receptor deficiency (GHRD) in human patients and animal models. We reviewed parameters of glucose metabolism in distinct age groups into two h
Autor:
Barbara Ludwig, Eckhard Wolf
Publikováno v:
Der Diabetologe. 16:662-668
Die Behandlungsmoglichkeiten des Diabetes mellitus haben sich in den letzten Jahren erheblich erweitert. Im nachsten Jahrzehnt konnte der kombinierte und konzertierte Einsatz pharmakologischer, biotechnologischer und zellbasierter Behandlungsstrategi
Autor:
Sabine Krause, Clara Kaufhold, Hiroshi Nagashima, Levin Arne Kobelke, Rüdiger Wanke, LM Fonteyne, Magdalena Lindner, Maila Chirivi, Peter Bartenstein, Claudia Bearzi, Gerhard Wess, Michael Stirm, Maggie C. Walter, Bachuki Shashikadze, Kaspar Matiasek, Nikolai Klymiuk, Georg J. Arnold, Andreas Lange, Valeri Zakhartchenko, Elisabeth Kemter, Eckhard Wolf, Mayuko Kurome, Andrea Bähr, Thomas Fröhlich, Martin Hrabĕ de Angelis, Christian Kupatt, Sven Reese, Florian Flenkenthaler, Arne Hinrichs, Ivica Medugorac, Roberto Rizzi, Christian Mayer, Andreas Blutke, Sibylle Ziegler, Barbara Kessler
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Dis. Model. Mech. 14:dmm049285 (2021)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Dis. Model. Mech. 14:dmm049285 (2021)
Large-animal models for Duchenne muscular dystrophy (DMD) are crucial for the evaluation of diagnostic procedures and treatment strategies. Pigs cloned from male cells lacking DMD exon 52 (DMDΔ52) exhibit molecular, clinical and pathological hallmar
Autor:
Qiuming Liao, Paolo Brenner, Peter J. Murray, Bruno Reichart, Andrea Bähr, Julia Radan, Eckhard Wolf, Ines Buttgereit, Reinhard Ellgass, Barbara Kessler, Riccardo Sfriso, David Ayares, Anastasia Milusev, Tanja Mayr, Alessandro Panelli, Maren Mokelke, Jan-Michael Abicht, Nikolai Klymiuk, Audrius Paskevicius, Stefanie Egerer, Stig Steen, Robert Rieben, Lara Issl, Trygve Sjöberg, Guangqi Qin, Jiawei Ying, Matthias Längin, Ann Kathrin Fresch, Christoph Walz
Publikováno v:
Längin, Matthias; Reichart, Bruno; Steen, Stig; Sjöberg, Trygve; Paskevicius, Audrius; Liao, Qiuming; Qin, Guangqi; Mokelke, Maren; Mayr, Tanja; Radan, Julia; Issl, Lara; Buttgereit, Ines; Ying, Jiawei; Fresch, Ann Kathrin; Panelli, Alessandro; Egerer, Stefanie; Bähr, Andrea; Kessler, Barbara; Milusev, Anastasia; Sfriso, Riccardo; ... (2021). Cold non-ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig-to-baboon xenotransplantation. Xenotransplantation, 28(1), e12636. Wiley 10.1111/xen.12636
Xenotransplantation
Xenotransplantation
BACKGROUND Successful preclinical transplantations of porcine hearts into baboon recipients are required before commencing clinical trials. Despite years of research, over half of the orthotopic cardiac xenografts were lost during the first 48 hours
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea2449e73c6eaf561cbf2e9e41fa137
Autor:
Peter J. Cowan, Joachim Denner, Reinhard Schwinzer, Eckhard Wolf, Bruno Reichart, Matthias Längin
Publikováno v:
Transplantation. 105(9)
Heart transplantation is the only long-lasting life-saving option for patients with terminal cardiac failure. The number of available human organs is however far below the actual need, resulting in substantial mortality of patients while waiting for
Autor:
Uwe Fiebig, Eckhard Wolf, Anastasia Milusev, Tanja Mayr, Fabian Luther, Joachim Denner, Christiane Stahl-Hennig, Luise Krueger, Julia Radan, Nicoletta Sorvillo, Paolo Brenner, Christoph Walz, Bruno Reichart, Matthias Laengin, Jan-Michael Abicht, Maren Mokelke, Robert Rieben, Berit Roshani
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Denner, Joachim; Längin, Matthias; Reichart, Bruno; Krüger, Luise; Fiebig, Uwe; Mokelke, Maren; Radan, Julia; Mayr, Tanja; Milusev, Anastasia; Luther, Fabian; Sorvillo, Nicoletta; Rieben, Robert; Brenner, Paolo; Walz, Christoph; Wolf, Eckhard; Roshani, Berit; Stahl-Hennig, Christiane; Abicht, Jan-Michael (2020). Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival. Scientific reports, 10(1), p. 17531. Springer Nature 10.1038/s41598-020-73150-9
Scientific Reports
Denner, Joachim; Längin, Matthias; Reichart, Bruno; Krüger, Luise; Fiebig, Uwe; Mokelke, Maren; Radan, Julia; Mayr, Tanja; Milusev, Anastasia; Luther, Fabian; Sorvillo, Nicoletta; Rieben, Robert; Brenner, Paolo; Walz, Christoph; Wolf, Eckhard; Roshani, Berit; Stahl-Hennig, Christiane; Abicht, Jan-Michael (2020). Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival. Scientific reports, 10(1), p. 17531. Springer Nature 10.1038/s41598-020-73150-9
Xenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic preservation with conti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddfb33c8a0f139edd10ec86f9bed5b34
http://edoc.rki.de/176904/9294
http://edoc.rki.de/176904/9294
People with diabetes mellitus have an increased risk for infections, however, there is still a critical gap in precise knowledge about altered immune mechanisms in this disease. Since diabetic INSC94Y transgenic pigs exhibit elevated blood glucose an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0517e1b3f6ee73658b27e6e65f310a42
https://doi.org/10.1101/2020.08.26.267914
https://doi.org/10.1101/2020.08.26.267914
Autor:
Reinhard Ellgass, Uwe Fiebig, Andrea Baehr, Audrius Paskevicius, Stig Steen, Mayuko Kurome, Julia Radan, Ralf R. Tönjes, Robert Rieben, Lara Issl, Barbara Kessler, Riccardo Sfriso, Jan-Michael Abicht, Trygve Sjöberg, Sebastian Michel, Thomas Kirchner, Christoph Walz, David Ayares, Luise Krüger, Paolo Brenner, Anastasia Milusev, Tanja Mayr, Christian Hagl, Uwe Schönmann, Bruno Reichart, Jiawei Ying, Matthias Längin, Antonia W. Godehardt, Ann Kathrin Fresch, Stefanie Egerer, Ines Buttgereit, Stefan Buchholz, Joachim Denner, Maren Mokelke, Elisabeth Kemter, Nikolai Klymiuk, Maks Mihalj, Karen Lampe, Valeri Zakhartchenko, Eckhard Wolf
Background The demand for donated human hearts far exceeds the number available. Xenotransplantation of genetically modified porcine organs provides an alternative. In 2000, an Advisory Board of the International Society for Heart and Lung Transplant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b180c54125324bd9aeaa0bff516bfdc1
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603840
Safe and reliable large animal diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents but is often critiqued in higher animals due to reduced efficacy, rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9e49ff78cf55c67578f9baf80585ca
https://www.zora.uzh.ch/id/eprint/208097/
https://www.zora.uzh.ch/id/eprint/208097/
Autor:
Juan Antonio Aguilar-Pimentel, Thomas Klopstock, Eckhard Wolf, Carsten B. Schmidt-Weber, Julia Calzada-Wack, Ralph Fingerhut, Lore Becker, Marie Lucienne, Valerie Gailus-Durner, D. Sean Froese, Nadine Spielmann, Wolfgang Wurst, Philipp Mayer-Kuckuk, Birgit Rathkolb, Lillian Garrett, Martin Hrabě de Angelis, Déborah Mathis, Jan Rozman, Matthias R. Baumgartner, Merima Forny, Dirk H. Busch, Irina Treise, Patricia da Silva-Buttkus, Helmut Fuchs, Oana V. Amarie, Sabine M. Hölter
Publikováno v:
Biochimica et biophysica acta / Molecular basis of disease 1866(3), 165622 (2020). doi:10.1016/j.bbadis.2019.165622
Biochim. Biophys. Acta-Mol. Basis Dis. 1866:165622 (2020)
Biochim. Biophys. Acta-Mol. Basis Dis. 1866:165622 (2020)
Isolated methylmalonic aciduria (MMAuria) is primarily caused by deficiency of methylmalonyl-CoA mutase (MMUT or MUT). Biochemically, MUT deficiency results in the accumulation of methylmalonic acid (MMA), propionyl-carnitine (C3) and other metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c74a41bb0ba27f5045f882d95511bc