Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Charles R. Mackay"'
Publikováno v:
Science China Life Sciences. 64:1829-1841
There is growing recognition that neutrophils play an important role in cancer initiation, progression and metastasis. Although they are typically characterized as short-lived effector cells, neutrophils have been shown to acquire immunosuppressive a
Autor:
Matthew Snelson, Gavin W. Lambert, Assam El-Osta, Grant R Drummond, D. Donner, Melinda T. Coughlan, Helen Kiriazis, Aanthony Vinh, Duncan Horlock, Charles R. Mackay, Waled A. Shihata, Hamdi A. Jama, Beverly Giam, Tim D. Spector, Chad Johnson, Mark Ziemann, Xiao-Jun Du, April Fiedler, Kirill Tsyganov, Francine Z. Marques, David M. Kaye, Sarah E. Phillips, Amrita Vijay, Ana M. Valdes
Publikováno v:
Circulation. 141:1393-1403
Background: High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. The impact of lac
Autor:
Sara Bordbar, Charles R. Mackay, Stephen M. Twigg, Eliana Mariño, Shannon Brodie, Sonia Saad, Marc R. Wilkins, Barbara Fazekas de St Groth, Long T. Nguyen, Emma E. Hamilton-Williams, Bree J. Tillett, Susan M. Corley, Courtney J. Wright, Helen M. McGuire, Yu Anne Yap, Kirstine J. Bell, Sussan Duong, Esteban Nicolas Gurzov, Leonard C. Harrison
BackgroundShort-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of beneficial bacteria, commonl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d99ceb0bb773c049b35a111f8cd051
https://doi.org/10.1101/2021.09.15.21263059
https://doi.org/10.1101/2021.09.15.21263059
Autor:
Melinda T. Coughlan, Waled A. Shihata, Louise M Burrell, Charles R. Mackay, Francine Z. Marques, Rikeish R. Muralitharan, Michael E Nakai, Matthew Snelson, David M. Kaye, Hamdi A. Jama, Chad Johnson, Evany Dinakis
Publikováno v:
Hypertension. 77
Autor:
Leigh Donnellan, Mark E. Cooper, Sih Min Tan, Brooke E. Harcourt, Mark Ziemann, Nicole J. Kellow, Josephine M. Forbes, Karly C. Sourris, Melinda T. Coughlan, David Steer, Rachel E. Clarke, Charles R. Mackay, Assam El-Osta, Sally A. Penfold, Tuong-Vi Nguyen, Matthew Snelson, Michael J. Davies, Cassandra de Pasquale, Vicki Thallas-Bonke, Runa S.J. Lindblom, Permal Deo, Trent M. Woodruff
Publikováno v:
Science Advances
Snelson, M, Tan, S M, Clarke, R E, De Pasquale, C, Thallas-Bonke, V, Nguyen, T V, Penfold, S A, Harcourt, B E, Sourris, K C, Lindblom, R S, Ziemann, M, Steer, D, El-Osta, A, Davies, M J, Donnellan, L, Deo, P, Kellow, N J, Cooper, M E, Woodruff, T M, Mackay, C R, Forbes, J M & Coughlan, M T 2021, ' Processed foods drive intestinal barrier permeability and microvascular diseases ', Science Advances, vol. 7, no. 14, eabe4841 . https://doi.org/10.1126/sciadv.abe4841
Snelson, M, Tan, S M, Clarke, R E, De Pasquale, C, Thallas-Bonke, V, Nguyen, T V, Penfold, S A, Harcourt, B E, Sourris, K C, Lindblom, R S, Ziemann, M, Steer, D, El-Osta, A, Davies, M J, Donnellan, L, Deo, P, Kellow, N J, Cooper, M E, Woodruff, T M, Mackay, C R, Forbes, J M & Coughlan, M T 2021, ' Processed foods drive intestinal barrier permeability and microvascular diseases ', Science Advances, vol. 7, no. 14, eabe4841 . https://doi.org/10.1126/sciadv.abe4841
This study shows how highly processed foods can cause innate immune inflammation that promotes chronic microvascular disease.
Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular disease
Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular disease
Autor:
Charles R. Mackay, Laurence Macia
Publikováno v:
Journal of Allergy and Clinical Immunology. 144:1513-1515
Autor:
Yunzi Liu, Yan J. Li, Yik W. Loh, Julian Singer, Weiping Zhu, Laurence Macia, Charles R. Mackay, Weiming Wang, Steven J. Chadban, Huiling Wu
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Short-chain fatty acids (SCFA) derived from gut microbial fermentation of fiber have been shown to exert anti-inflammatory and immune-modulatory properties in acute kidney injury (AKI). However the direct mechanistic link between SCFAs, diet and the
Autor:
Yanjun Li, Xiaochen Chen, Yunzi Liu, Tony Kwan, Yik Wen Loh, Steven J. Chadban, Huiling Wu, Julian Singer, Laurence Macia, Jian Tan, Jin Ma, Charles R. Mackay
Publikováno v:
J Am Soc Nephrol
Background Studies have reported "dysbiotic" changes to gut microbiota, such as depletion of gut bacteria that produce short-chain fatty acids (SCFAs) through gut fermentation of fiber, in CKD and diabetes. Dietary fiber is associated with decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e509d83eb26d18d4a7b8c46ff013e92
https://europepmc.org/articles/PMC7269358/
https://europepmc.org/articles/PMC7269358/
Autor:
Charles R. Mackay, Samantha L. Dawson, Sarath Ranganathan, John Molloy, John B. Carlin, Michael A. Conlon, Karen E. Nelson, Laurence Macia, David Topping, Margarita Moreno-Betancur, Mimi L.K. Tang, Katrina J. Allen, Fiona Collier, Jennifer J. Koplin, Leonard C. Harrison, Richard Saffery, Martin O'Hely, Peter D. Sly, Angela Pezic, Peter Vuillermin, Anne-Louise Ponsonby, Lawrence E. K. Gray
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Nature Communications
Nature Communications
In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus th
Autor:
Liang Xie, Jahangir Alam, Farnaz Fahimi, Charles R. Mackay, Caroline Ang, Marco J Herold, Andrew J. Kueh, Remy Robert, Stephen B. Willingham
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Neutrophils are the most abundant effector cells of the innate immune system and represent the first line of defense against infection. However, in many common pathologies, including autoimmune diseases, excessive recruitment and activation of neutro