Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Abigail Ngoepe"'
Autor:
Khadija Khan, Gila Lustig, Farina Karim, Bernadett I Gosnell, Suzaan Marais, Prakash Jeena, Rohen Harrichandparsad, Anne Derache, Sandile Cele, Mahomed-Yunus S. Moosa, Ravindra K. Gupta, Katya Govender, Alex Sigal, Ntombi Ntshuba, Abigail Ngoepe, Vinod B. Patel, John H. Adamson, Henrik N. Kløverpris
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009871 (2021)
Lustig, G, Cele, S, Karim, F, Derache, A, Ngoepe, A, Khan, K, Gosnell, B I, Moosa, M Y S, Ntshuba, N, Marais, S, Jeena, P M, Govender, K, Adamson, J, Kløverpris, H, Gupta, R K, Harrichandparsad, R, Patel, V B & Sigal, A 2021, ' T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy ', PLOS Pathogens, vol. 17, no. 9, e1009871 . https://doi.org/10.1371/journal.ppat.1009871
PLoS Pathogens
Lustig, G, Cele, S, Karim, F, Derache, A, Ngoepe, A, Khan, K, Gosnell, B I, Moosa, M Y S, Ntshuba, N, Marais, S, Jeena, P M, Govender, K, Adamson, J, Kløverpris, H, Gupta, R K, Harrichandparsad, R, Patel, V B & Sigal, A 2021, ' T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy ', PLOS Pathogens, vol. 17, no. 9, e1009871 . https://doi.org/10.1371/journal.ppat.1009871
PLoS Pathogens
HIV cerebrospinal fluid (CSF) escape, where HIV is suppressed in blood but detectable in CSF, occurs when HIV persists in the CNS despite antiretroviral therapy (ART). To determine the virus producing cell type and whether lowered CSF ART levels are
Autor:
Alasdair Leslie, Nicholas Herbert, Henrik N. Kløverpris, Alveera Singh, Fusi G. Madela, Thumbi Ndung'u, Vukani T. Manzini, Katya Govender, Ntombifuthi Mthabela, Kavidha Reddy, Frank Anderson, Farina Karim, John H. Adamson, Yenzekile Zungu, Faith Nene, Rabiah Fardoos, J Zachary Porterfield, Abigail Ngoepe, Dirhona Ramjit, Osaretin E. Asowata
Publikováno v:
JCI Insight
Asowata, O E, Singh, A, Ngoepe, A, Herbert, N, Fardoos, R, Reddy, K, Zungu, Y, Nene, F, Mthabela, N, Ramjit, D, Karim, F, Govender, K, Ndung’u, T, Zachary Porterfield, J, Adamson, J H, Madela, F G, Manzini, V T, Anderson, F, Leslie, A & Kløverpris, H N 2021, ' Irreversible depletion of intestinal CD4 + T cells is associated with T cell activation during chronic HIV infection ', JCI insight, vol. 6, no. 22, e146162 . https://doi.org/10.1172/jci.insight.146162
JCI Insight.
Asowata, O E, Singh, A, Ngoepe, A, Herbert, N, Fardoos, R, Reddy, K, Zungu, Y, Nene, F, Mthabela, N, Ramjit, D, Karim, F, Govender, K, Ndung’u, T, Zachary Porterfield, J, Adamson, J H, Madela, F G, Manzini, V T, Anderson, F, Leslie, A & Kløverpris, H N 2021, ' Irreversible depletion of intestinal CD4 + T cells is associated with T cell activation during chronic HIV infection ', JCI insight, vol. 6, no. 22, e146162 . https://doi.org/10.1172/jci.insight.146162
JCI Insight.
HIV infection in the human gastrointestinal (GI) tract is thought to be central to HIV progression, but knowledge of this interaction is primarily limited to cohorts within Westernized countries. Here, we present a large cohort recruited from high HI
Autor:
Warren Kuhn, Duran Ramsuran, Maximilian Muenchhoff, Philip J. R. Goulder, Jane Millar, Alasdair Leslie, J Roider, Alex K. Shalek, Thumbi Ndung'u, Henrik N. Kløverpris, Osaretin E. Asowata, Kami C. Krista, Samuel W. Kazer, Amanda Ardain, Farina Karim, Abigail Ngoepe, Rabiah Fardoos, Alveera Singh
Publikováno v:
Cell Reports
Singh, A, Kazer, S W, Roider, J, Krista, K C, Millar, J, Asowata, O E, Ngoepe, A, Ramsuran, D, Fardoos, R, Ardain, A, Muenchhoff, M, Kuhn, W, Karim, F, Ndung'u, T, Shalek, A K, Goulder, P, Leslie, A & Kløverpris, H N 2020, ' Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy ', Cell Reports, vol. 32, no. 11, 108153 . https://doi.org/10.1016/j.celrep.2020.108153
Singh, A, Kazer, S W, Roider, J, Krista, K C, Millar, J, Asowata, O E, Ngoepe, A, Ramsuran, D, Fardoos, R, Ardain, A, Muenchhoff, M, Kuhn, W, Karim, F, Ndung'u, T, Shalek, A K, Goulder, P, Leslie, A & Kløverpris, H N 2020, ' Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy ', Cell Reports, vol. 32, no. 11, 108153 . https://doi.org/10.1016/j.celrep.2020.108153
Summary Innate lymphoid cells (ILCs) are important for response to infection and for immune development in early life. HIV infection in adults depletes circulating ILCs, but the impact on children infected from birth remains unknown. We study vertica
Autor:
Rabiah Fardoos, Alasdair Leslie, Amanda Ardain, Alex K. Shalek, Duran Ramsuran, Alveera Singh, Jane Millar, Warren Kuhn, Thumbi Ndung'u, Henrik N. Kløverpris, Farina Karim, Osaretin E. Asowata, Philip J. R. Goulder, Julia Roider, Abigail Ngoepe, Kami C. Krista, Samuel W. Kazer, Maximilian Muenchhoff
Publikováno v:
SSRN Electronic Journal.
Innate lymphoid cells (ILCs) are important for response to infection and immune development in early life. HIV infection in adults has a profound effect on ILCs, but the impact from birth is unknown. Here we studied vertically HIV infected children f
Autor:
Julia Roider, Takashi Maehara, Abigail Ngoepe, Duran Ramsuran, Maximilian Muenchhoff, Emily Adland, Toby Aicher, Samuel W. Kazer, Pieter Jooste, Farina Karim, Warren Kuhn, Alex K. Shalek, Thumbi Ndung'u, Lynn Morris, Penny L. Moore, Shiv Pillai, Henrik Kløverpris, Philip Goulder, Alasdair Leslie
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in immunology
Frontiers
Roider, J, Maehara, T, Ngoepe, A, Ramsuran, D, Muenchhoff, M, Adland, E, Aicher, T, Kazer, S W, Jooste, P, Karim, F, Kuhn, W, Shalek, A K, Ndung'u, T, Morris, L, Moore, P L, Pillai, S, Kløverpris, H, Goulder, P & Leslie, A 2018, ' High-frequency, functional HIV-specific T-follicular helper and regulatory cells are present within germinal centers in children but not adults ', Frontiers in Immunology, vol. 9, 1975 . https://doi.org/10.3389/fimmu.2018.01975
Frontiers in immunology
Frontiers
Roider, J, Maehara, T, Ngoepe, A, Ramsuran, D, Muenchhoff, M, Adland, E, Aicher, T, Kazer, S W, Jooste, P, Karim, F, Kuhn, W, Shalek, A K, Ndung'u, T, Morris, L, Moore, P L, Pillai, S, Kløverpris, H, Goulder, P & Leslie, A 2018, ' High-frequency, functional HIV-specific T-follicular helper and regulatory cells are present within germinal centers in children but not adults ', Frontiers in Immunology, vol. 9, 1975 . https://doi.org/10.3389/fimmu.2018.01975
Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmission. To better understand the mechanisms by which HIV-specific bnAbs naturally develop, we investigated blood and lymphoid tissue in pediatric infecti