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Publikováno v:
Immunopharmacology and Immunotoxicology. 44:586-593
Background: Dexmedetomidine (DEX) has showed significant analgesic effects in neuropathic pain, but the underlying mechanism has remained elusive. Our present study aimed to explore the effect of DEX on hyperalgesia with the involvement of p38MAPK si
Publikováno v:
NeuroToxicology. 88:1-13
Cognitive impairment or "chemobrain" is a troublesome adverse effect which had been increasingly reported by cancer patients after doxorubicin (DOX) chemotherapy. Notably, Hypertension, a very common comorbidity in cancer patients, could pose a great
Autor:
Helen E. Ritchie, Elizabeth Hegedus, Dominqiue Abela, Andrew M. Howe, Emma Farrell, Deena Ababneh
Publikováno v:
Reproductive Toxicology. 106:109-114
Phenytoin is a known human teratogen with unknown etiology. Several mechanisms have been proposed including disturbances in folate metabolism, induction of embryonic hypoxia following phenytoin-induced bradycardia, free radical formation following re
Publikováno v:
NeuroToxicology. 87:24-29
Opioid overdoses (ODs) are increasing in Mexico's northern border. Because naloxone is usually not available, witnesses inject common salt (NaCl) into a vein of OD victims in an attempt to help them regain consciousness. Despite this widespread pract
Autor:
Camille S. Westlake, David M. Aronoff
Publikováno v:
Current Drug Safety. 16:299-308
Background: Ivermectin is widely used for the treatment of neglected tropical diseases associated with adverse maternal and fetal outcomes when the infection complicates the pregnancy. However, the United States FDA classification and current distrib
Publikováno v:
Current Drug Safety. 16:259-263
Background: Colistin utilization has gradually increased worldwide with the rising of multidrug-resistant (MDR) gram-negative bacilli despite its nephrotoxicity. Lipid emulsion (LE) is widely used for the toxic overdose treatment of various drugs. Ob
Autor:
Wijitra Chumboatong, Jiraporn Tocharus, Piyarat Govitrapong, Satchakorn Khamchai, Chainarong Tocharus
Publikováno v:
Neurotoxicity Research. 40:259-266
Cerebral ischemic stroke is one of the main causes of death and long-term disability worldwide. However, the mechanism is unclear, and treatments are limited. In this study, we aimed to investigate the anti-inflammatory effect of agomelatine in a per
Autor:
Waleed Al Abdulmonem, Sultan A. Alsuhaibani, Ayman M. Mousa, Abdullah S. M. Aljohani, Ahmed A. H. Abdellatif, Ahmed M. S. Hegazy, Sayed Y. Elsheikh, Suliman A. Alsagaby, Fahad A. Alhumaydhi, Khaled E.A. Soliman, Mohammad S. Alkhowailed, Osamah Al Rugaie, Hanan S. Seleem, Abdullah M Alnuqaydan, Mohamad Y. R. Yosof, Ameen S. S. Alwashmi, Ali Yousif Babiker, Mohammad Aljasir
Publikováno v:
Cutaneous and Ocular Toxicology. 41:33-42
Psoriasis is a chronic multifactorial inflammatory disease that affects 3% of people worldwide. Ustekinumab is a selective anti-IL-12/23 biologic that alleviates psoriasis, and curcumin is a natural, effective dietary turmeric extract applied to trea
Autor:
Eduardo R. Zimmer, Jaderson Costa da Costa, Gianina Teribele Venturin, Angela T. S. Wyse, Guilherme Schu, Felipe Schmitz, Samuel Greggio, Josiane Silva Silveira
Publikováno v:
Neurotoxicity Research. 39:1830-1845
Methylphenidate (MPH) has been widely misused by children and adolescents who do not meet all diagnostic criteria for attention-deficit/hyperactivity disorder without a consensus about the consequences. Here, we evaluate the effect of MPH treatment o
Autor:
Mohamed Ibrahim, Yasmine F. Ibrahim, Maha Y. Kamel, Asmaa Ma Bayoumi, Marwa M.M. Refaie, Sara M Ahmed, Rabab A Moussa
Publikováno v:
Human & Experimental Toxicology. 40:S788-S803
Hepatocellular carcinoma (HCC) accounts for more than 5% of all human cancers. Diacerein (DIA), an interleukin (IL)-1β inhibitor, is used for the treatment of osteoarthritis. DIA is a potential anticancer drug acting on several protein targets in th