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Publikováno v:
NeuroToxicology. 88:1-13
Cognitive impairment or "chemobrain" is a troublesome adverse effect which had been increasingly reported by cancer patients after doxorubicin (DOX) chemotherapy. Notably, Hypertension, a very common comorbidity in cancer patients, could pose a great
Autor:
Aml Salem Saleh Ahmed
Publikováno v:
Toxicology Mechanisms and Methods. 32:97-105
Doxorubicin (DOX) is the most effective and frequently used anticancer drug but its cardiotoxicity is the most important side effect that limits the clinical use of it. This study was designed to investigate the protective role of catechin (CAT) on D
Publikováno v:
Drug and Chemical Toxicology. 45:2568-2575
Gentamicin (GM) is an antibiotic belonging to an aminoglycoside family that might induce nephrotoxicity in human and animal models via oxidative stress. Toll-like receptors (TLRs) are part of innat...
Autor:
Leon F. Stankowski, Sarah Ann Tincher, Isaac V. Cohen, Tyson Paul Dubnicka, Sara Beth Hurtado, Berra Yazar-Klosinski, Laken Barber
Publikováno v:
Journal of Psychopharmacology (Oxford, England)
3,4 Methylenedioxymethamphetamine (MDMA)-assisted therapy has been recently found to be highly effective for treatment of posttraumatic stress disorder (PTSD). Previous studies have been inconclusive in elucidating potential MDMA genotoxicity. We per
Autor:
R. Ravindran, Rajendran Harishkumar, Chinnadurai Immanuel Selvaraj, Johnsamuel Godwin Christopher
Publikováno v:
Cardiovascular Toxicology. 21:947-963
Chemotherapeutic drugs are a known factor that impairs the system of life due to their severe side effects. A more worrying fact is that the patients administered with doxorubicin fall under the risk of cardiotoxicity. The evolution of exploring plan
Publikováno v:
Immunopharmacology and Immunotoxicology. 43:571-583
Ulcerative colitis (UC) is a chronic inflammatory bowel condition considered by oxido-nitrosative stress and the release of pro-inflammatory cytokines that affects the mucosal lining of the colon. Sarsasapogenin (SG), as an active component, has been
Autor:
Halis Suleyman, Ferda Keskin Cimen, Erel Icel, Turgay Ucak, Nurdan Gamze Tasli, Adem Ugurlu, Yücel Karakurt, Sumeyye Burcu Agcayazi
Publikováno v:
Cutaneous and Ocular Toxicology. 40:263-267
Aim To investigate the effects of resveratrol on oxidative stress and inflammation parameters and histological alterations in cisplatin-induced optic nerve damage in a mouse model. Material and method Thirty-six albino Wistar male rats were divided i
Autor:
Hong Zheng, Partha S. Saha, Kirsten R. Kim Sawtelle, Jamie L. Scholl, William G. Mayhan, Denise M. Arrick, Brittany N. Bamberg, Michael J. Watt
Publikováno v:
Alcoholism: Clinical and Experimental Research. 45:1359-1369
BACKGROUND Prenatal exposure to alcohol leads to a greater incidence of many cardiovascular-related diseases, presumably via a mechanism that may involve increased oxidative stress. An agonist of peroxisome proliferator-activated receptor gamma (PPAR
Autor:
Refiye Yanardag, Ilknur Bugan, Omur Karabulut-Bulan, Bertan Boran Bayrak, Pınar Koroglu-Aydın
Publikováno v:
Toxicology Mechanisms and Methods. 31:489-500
Diabetes and cancer have common physiological and biochemical mechanisms. Metformin is the preferred drug of choice for the treatment of diabetes. Prostate cancer can be modeled in by injection of MAT-Lylu cells. A model of diabetes in rats is induce
Publikováno v:
Environmental Toxicology. 36:1683-1693
As an environmental contaminant, Benzo[a]pyrene (B[a]P; BaP) disrupts the antioxidant signaling and thus leads to the induction of oxidative stress and the damage of DNA in the ovary. low-dose atorvastatin (ATV) has antioxidant and anti-apoptotic pro