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Publikováno v:
Immunopharmacology and Immunotoxicology. 44:586-593
Background: Dexmedetomidine (DEX) has showed significant analgesic effects in neuropathic pain, but the underlying mechanism has remained elusive. Our present study aimed to explore the effect of DEX on hyperalgesia with the involvement of p38MAPK si
Autor:
Waleed Al Abdulmonem, Sultan A. Alsuhaibani, Ayman M. Mousa, Abdullah S. M. Aljohani, Ahmed A. H. Abdellatif, Ahmed M. S. Hegazy, Sayed Y. Elsheikh, Suliman A. Alsagaby, Fahad A. Alhumaydhi, Khaled E.A. Soliman, Mohammad S. Alkhowailed, Osamah Al Rugaie, Hanan S. Seleem, Abdullah M Alnuqaydan, Mohamad Y. R. Yosof, Ameen S. S. Alwashmi, Ali Yousif Babiker, Mohammad Aljasir
Publikováno v:
Cutaneous and Ocular Toxicology. 41:33-42
Psoriasis is a chronic multifactorial inflammatory disease that affects 3% of people worldwide. Ustekinumab is a selective anti-IL-12/23 biologic that alleviates psoriasis, and curcumin is a natural, effective dietary turmeric extract applied to trea
Autor:
Mohamed Ibrahim, Yasmine F. Ibrahim, Maha Y. Kamel, Asmaa Ma Bayoumi, Marwa M.M. Refaie, Sara M Ahmed, Rabab A Moussa
Publikováno v:
Human & Experimental Toxicology. 40:S788-S803
Hepatocellular carcinoma (HCC) accounts for more than 5% of all human cancers. Diacerein (DIA), an interleukin (IL)-1β inhibitor, is used for the treatment of osteoarthritis. DIA is a potential anticancer drug acting on several protein targets in th
Publikováno v:
Human & Experimental Toxicology. 40:S593-S602
Erythropoietin (EPO) has antiapoptotic, antioxidative, and anti-inflammatory effects on ischemia tissues and protects against acute lung injury (ALI) induced by ischemia-reperfusion (I/R). p38 mitogen-activated protein kinases (p38 MAPK) signaling is
Publikováno v:
Alcohol. 96:55-61
Alcohol abuse has become a serious health issue worldwide. Ketamine can reduce addiction risk among patients with alcohol use disorders. This study aimed to determine the effects of alcohol on the pharmacokinetics of ketamine during long-term alcohol
Publikováno v:
Human & Experimental Toxicology. 40:S540-S552
Ischemic stroke is a leading cause of death and long-term disability worldwide. The aim of this study is to explore the potential function of ephedrine in ischemic stroke and the underlying molecular mechanism. A middle cerebral artery occlusion (MCA
Autor:
Gellan Alaa Mohamed Kamel
Publikováno v:
Human & Experimental Toxicology. 40:S509-S518
Background Fluoxetine (FLX) has been widely used as first-line treatment in cases of depression and other neuropsychiatric disorders. Although its safety has been approved, the use of FLX was associated with liver injury and chronic liver disease. Vi
Publikováno v:
Drug and Chemical Toxicology. 45:2678-2685
Methotrexate is an important immunosuppressive and antineoplastic drug and is widely used for treatment. However, hepatotoxicity is one of the major adverse effects of methotrexate. In this study, it was aimed to investigate whether ramelteon has a p
Publikováno v:
Immunopharmacology and Immunotoxicology. 43:758-766
Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) exposure might be considerably associated with a decreased risk of Alzheimer's disease (AD). Therefore, we conducted an experiment to investigate the impact of indomethacin (IND) on inflammaso
Autor:
Moncef Fekih, Emna Gaïes, Hammami Mohamed Bassem, Ridha Ben Ali, Michelle-Véronique Elmay, Israa Dahmani, Sihem El Aïdli, Dorra Ben Said, Achraf Chedly
Publikováno v:
Drug and Chemical Toxicology. 45:2594-2600
Isoniazid (INH), being the first-line drug used as an anti-tuberculosis drug, is known to be associated with physiological deteriorations including hepatic and neurologic disturbances. This study was aimed at biochemical and behavioral characterizati