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Autor:
Ralf Dürrwald, Eliza Wiercinska, Amelie Schwenger, Hubert Serve, Olivier Ballo, Marek Widera, Julius Christoph Enssle, Helen Hellstern, Sandra Ciesek, Julia Campe, Michael A. Rieger, Halvard Bonig, Sebastian Wolf, Holger F. Rabenau, Björn Steffen, Evelyn Ullrich, Ivana von Metzler
Publikováno v:
Blood
Three reports address the protection of the vulnerable population of patients with hematologic malignancies in the face of the ongoing COVID pandemic. The reports suggest that some patients who fail to mount a B-cell response to vaccine may neverthel
Publikováno v:
Cytotherapy. 23:985-990
Background aims Chimeric antigen receptor (CAR)-modified T-cell therapy has revolutionized outcomes for patients with relapsed/refractory B-cell malignancies. Despite the exciting results, several clinical and logistical challenges limit its wide app
Autor:
Brian S. Gloss, Kavitha Gowrishankar, Piers Blombery, Raymond H. Y. Louie, Kenneth P. Micklethwaite, Emily Blyth, Fritz J. Sedlazeck, Janine Street, David Gottlieb, Matthew MacKay, Christopher E. Mason, David Bishop, Leili Moezzi, Gaurav Sutrave, Curtis Cai, Ziduo Li, Leighton Clancy, Fabio Luciani, Jonathan Foox, Melanie A Mach
Publikováno v:
Blood. 138:1391-1405
We performed a phase 1 clinical trial to evaluate outcomes in patients receiving donor-derived CD19-specific chimeric antigen receptor (CAR) T cells for B-cell malignancy that relapsed or persisted after matched related allogeneic hemopoietic stem ce
Autor:
Mathie P.G. Leers, Sabine Puts, Kelly E J M Pelzer, Roosmarie J. M. Drent, Debbie S. Deben, Dennis R Wong, Adriaan A van Bodegraven, Arjan J van Adrichem
Publikováno v:
Cytometry Part A. 101:167-176
Thiopurine derivatives, such as azathioprine and mercaptopurine, are standard conventional treatment options in inflammatory bowel disease (IBD). Unfortunately, approximately half of patients discontinue thiopurine therapy within 2 years. To improve
Publikováno v:
Cell Biology International. 45:2395-2402
Aplastic anemia (AA) is an autoimmune disorder characterized by bone marrow and peripheral blood pancytopenia. Different environmental and genetical conditions could be effective in an outbreak of this disease. The exact pathogenesis of this disease,
Autor:
Tao Wang, Helen E. Heslop, Stephen Gottschalk, Bambi Grilley, Rammurti T. Kamble, Carlos A. Ramos, Ann M. Leen, Meng-Fen Wu, Malcolm K. Brenner, Robert A. Krance, Catherine Robertson, Manik Kuvalekar, Jasleen K. Randhawa, Spyridoula Vasileiou, Adrian P. Gee, Suhasini Lulla, Juan F. Vera, Betty Chung, Ayumi Watanabe, Premal Lulla, Ifigeneia Tzannou, Swati Naik, LaQuisa Hill, George Carrum
Publikováno v:
Blood
Relapse after allogeneic hematopoietic stem cell transplantation (HCT) is the leading cause of death in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Infusion of unselected donor lymphocytes (DLIs) enhances the graft-v
Autor:
Hyeonjeong Kang, Housheng Hansen He, Mark D. Minden, Li Zhang, Jong Bok Lee, Yong Zeng, Dalam Ly, Enoch Tin, Fraser Soares, Nayeema Akhtar, Branson Chen, Musaddeque Ahmed
Publikováno v:
Blood. 137:2171-2181
Acute myeloid leukemia (AML) remains a devastating disease in need of new therapies to improve patient survival. Targeted adoptive T-cell therapies have achieved impressive clinical outcomes in some B-cell leukemias and lymphomas but not in AML. Doub
Autor:
Edward D. Ball, Bjoern Peters, Valentina Ferrari, Alison Tarke, Colin McCarthy, Asad Bashey, Rafael Bejar, Trevor Conley, Hannah Fields, Franco Ferrari, Luca Ferrari, Thomas A. Lane, A Vitiello, Zeynep Kosaloglu-Yalcin, Tiffany N. Tanaka, Dimitrios Tzachanis, Alessandro Sette
Publikováno v:
Cytotherapy. 23:320-328
Therapies that utilize immune checkpoint inhibition work by leveraging mutation-derived neoantigens and have shown greater clinical efficacy in tumors with higher mutational burden. Whether tumors with a low mutational burden are susceptible to neoan
Autor:
Colin McCarthy, Luca Ferrari, Hannah Fields, A Vitiello, Amber P. Sanchez, Franco Ferrari, Alison Tarke, Rafael Bejar, Tiffany N. Tanaka, Thomas A. Lane, Valentina Ferrari
Publikováno v:
Cytotherapy. 23:236-241
Background Myelodysplastic syndromes (MDS) represent the most common type of acquired bone marrow failure in adults and is characterized by ineffective maturation of myeloid precursor cells and peripheral cytopenias associated with higher rates of in
Autor:
Lucy MacDonald, Umberto G. Fazzi, Neal L. Millar, Emma Garcia-Melchor, Iain B. McInnes, Lindsay A. N. Crowe, Shatakshi Sood, Giacomo Cafaro, Michael McLean, Moeed Akbar
Publikováno v:
Annals of the Rheumatic Diseases
ObjectivesIncreasing evidence suggests that inflammatory mechanisms play a key role in chronic tendon disease. After observing T cell signatures in human tendinopathy, we explored the interaction between T cells and tendon stromal cells or tenocytes