Zobrazeno 1 - 5
of 5
pro vyhledávání: '"John Nolan"'
Autor:
John Nolan, E. Martin Fielden, Matthew A. Naylor, Peter O'Neill, Bridget M. Sutton, Gerald E. Adams, Ian J. Stratford
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 29:333-337
To study the reduction of RB90740 (1), a fused pyrazine mono-N-oxide that has an oxic:hypoxic cytotoxicity ratio of10 in a range of murine and human tumor cells in vitro.Reduction of 1 has been initiated radiolytically and photochemically in aqueous
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 22:655-659
Tritiated misonidazole (MISO) was injected intravenously (iv) into mice bearing five different tumors. At 24 hr the tumors were removed for analysis of bound MISO, and at the same time three normal tissues were removed (liver, labial gland, and esoph
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 18:347-351
The retention of labelled misonidazole (MISO) was measured in a range of normal tissues in the mouse 24 hr after the intravenous injection of [14C]MISO (ring labelled) and [3H]-MISO (side-arm labelled). For [14C]MISO the 24 hr tissue retention, in or
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
Scopus-Elsevier
The vaso-active drug hydralazine causes a considerable increase in the cytotoxic effect of melphalan towards the KHT tumour in mice. The enhancement in response, measured as the concentration of melphalan required to achieve a given tumour response,
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 16:953-956
The localization of tritiated misonidazole metabolites in a number of normal tissues in the mouse is reported from autoradiography. The labeled misonidazole was injected at 750 or 75 mg/kg body weight (Rel. Sp. Act. 74 and 740 MBq/mg respectively). T