Zobrazeno 1 - 10
of 26
pro vyhledávání: '"John R. Foster"'
Publikováno v:
Haschek and Rousseaux's Handbook of Toxicologic Pathology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be648be9c37a0c1e5db3aeaee9076196
https://doi.org/10.1016/b978-0-12-821044-4.00008-x
https://doi.org/10.1016/b978-0-12-821044-4.00008-x
Publikováno v:
Toxicologic pathology. 48(3)
The increased concern on the consequence of exposure to multiple chemical combinations has led national regulatory authorities to develop different concepts to conduct risk assessments on chemical mixtures. Pesticide residues were identified as “pr
Autor:
Andrew G. Smith, John R. Foster
Publikováno v:
Toxicology Research
The haem biosynthetic pathway is of fundamental importance for cellular metabolism both for the erythroid and nonerythroid tissues.
The haem biosynthetic pathway is of fundamental importance for cellular metabolism both for the erythroid and non
The haem biosynthetic pathway is of fundamental importance for cellular metabolism both for the erythroid and non
Autor:
Michael J. Graziano, Solomon Haile, John R. Foster, Bassem Attalla, Magnus Söderberg, Evan B. Janovitz, Shen-Jue Chen, Karen Granaldi, Yunling Song, Mark Tirmenstein, Martin Billger, Thomas Dorr, Raja Mangipudy, Kristina D. Chadwick, Ann-Marie Bergholm, Melissa Czajkowski
Publikováno v:
Toxicologic pathology. 46(2)
The purpose of this study was to establish a 2-stage model of urinary bladder carcinogenesis in male Sprague-Dawley rats to identify tumor promoters. In phase 1 of the study, rats ( n = 170) were administered 100 mg/kg of the tumor initiator, N-butyl
Publikováno v:
Smart Dams and Reservoirs.
Autor:
John R. Foster
This chapter describes the normal functional anatomy and embryology of the liver, and provides detailed descriptions of the common spontaneous, and chemically induced, lesions in the liver of the Sprague-Dawley, Fischer F344, and Wistar rat strains.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8871b814b7a6c558bdcf133d01a8dd17
https://doi.org/10.1016/b978-0-12-391448-4.00009-5
https://doi.org/10.1016/b978-0-12-391448-4.00009-5
Autor:
John R. Foster, Noel Downes
Publikováno v:
Toxicologic Pathology. 43:1064-1073
Throughout the last 50 years, the paradigm for carcinogenicity assessment has depended on lifetime bioassays in rodents. Since 1997, the International Conference on Harmonisation (ICH) S1B has permitted the use of a 2-year rodent bioassay (usually in
Autor:
John R. Foster
Publikováno v:
Toxicologic Pathology. 47:902-902
Autor:
Paul G. Germann, Sabine Francke, Lindsay Tomlinson, Johannes Harleman, Gabriele Pohlmeyer-Esch, Charles E. Wood, Hirofumi Nagai, Agnes Schulte, Barbara Lenz, Henri Caplain, Takanori Harada, Xavier Palazzi, Mikala Skydsgaard, John E. Burkhardt, Wolfgang Kaufmann, Midori Yoshida, Sibylle Gröters, Kosei Inui, Vicki L. Dellarco, Pierluigi Fant, John R. Foster
Publikováno v:
Toxicologic pathology. 44(6)
The identification of adverse health effects has a central role in the development and risk/safety assessment of chemical entities and pharmaceuticals. There is currently a need for better alignment regarding how nonclinical adversity is determined a
Autor:
Robert R. Maronpot, Agnes Schulte, Karin Küttler, A. Nishikawa, Takanori Harada, Anthony P. Hall, Thomas Nolte, David E. Malarkey, John R. Foster, C. R. Elcombe, Wolfgang Kaufmann, Volker Strauss, Malcolm York, Anja Knippel
Publikováno v:
Toxicologic Pathology. 40:971-994
Preclinical toxicity studies have demonstrated that exposure of laboratory animals to liver enzyme inducers during preclinical safety assessment results in a signature of toxicological changes characterized by an increase in liver weight, hepatocellu