Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jae J. Song"'
Publikováno v:
Oncotarget
// So Young Kim 1, * , Dongxu Kang 1, 2, * , Hye Jin Choi 3 , Yeonsoo Joo 1, 4 , Joo-Hang Kim 5 , Jae J. Song 1, 4 1 Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Korea 2 Department of Oncology, Affiliated Hospital of Y
Publikováno v:
Apoptosis. 21:351-364
In this study, we demonstrated that survivin downregulation with TRAIL expression greatly enhanced the cytotoxic death of pancreatic cancer cells after gemcitabine treatment. Using real-time RT-PCR, we analyzed five survivin shRNAs to identify the be
Publikováno v:
Yonsei Medical Journal
Purpose Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism in the resista
Autor:
Dongxu Kang, Hye Jin Choi, Eun Kyung Kim, So Y. Kim, Seungha Lee, Jae J. Song, Sujin Kang, Joo Hang Kim
Publikováno v:
Cancer Research. 74:694-694
Gemcitabine as the standard chemotherapy agent to pancreatic cancer has proved effective; however, the response rate remains at 5.4% and the 5-year survival rate is extremely poor. Due to the shortcomings of gemcitabine and the presence of gemcitabin
Publikováno v:
Molecular Cancer Therapeutics. 12:C237-C237
Although the combination of gemcitabine with a variety of cytotoxic and targeted agents has generally shown no significant survival advantage as compared with gemcitabine alone, still, many targeted agents against various pathways remain to be tested
Publikováno v:
Cancer Research. 73:2957-2957
TRAIL-induced activation of Akt catalytic activity and phosphorylation were highly correlated with p38/HSP27 phosphorylation, whereas the phosphorylation of p38/HSP27 increased further during incubation with curcumin and TRAIL, which caused significa
Autor:
Sun Min Lim, Byoung Chul Cho, Hyo Sup Shim, Hye Ryun Kim, Soo Youl Kim, Joo Hang Kim, Jae Heon Jeong, Kyung Young Chung, Se Kyu Kim, S. M. Bakhtiar Ul Islam, Jae J. Song
Publikováno v:
Journal of Korean Medical Science
Transglutaminase 2 (TG2), a cross-linking enzyme, is involved in drug resistance and in the constitutive activation of nuclear factor kappa B (NF-κB). We investigated the association of non-small cell lung cancer (NSCLC) treatment efficacy with TG2
Autor:
So Y. Kim, Joo Hang Kim, Wungki Park, Jae J. Song, Jina Kim, Hyo R. Yoon, Kijae Hong, Hye Jin Choi, Seeun Oh, Sujin Kang
Publikováno v:
Cancer Research. 71:C42-C42
Previously, we have shown that p38-HSP27 acted as modulators from survival to death depending on the apoptotic strength in prostate cancer cells. For example, if the apoptotic strength is in the moderate range, p38-HSP27 acted to increase Akt catalyt
Autor:
Jae J. Song, Joo Hang Kim, So Y. Kim, Hoan N. Nguyen, Hyo R. Yoon, Seeun Oh, Bo K. Sun, Hye Jin Choi
Publikováno v:
Cancer Research. 71:4107-4107
The effect of combination of TRAIL and curcumin enhanced apoptotic cell death in many other studies. However, the exact molecular mechanism of enhanced apoptotic cell death by TRAIL plus curcumin was not yet completely understood. In this study, we c