Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Gil Atzmon"'
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Robert P. Adelson, Yun Freudenberg-Hua, Alison Goate, Nir Barzilai, Gil Atzmon, Peter Davies, Jeremy Koppel, Brian Fulton-Howard, Marc L. Gordon
Publikováno v:
Neurobiol Aging
To evaluate how age and apolipoprotein E-e4 (APOE4) status interact with APOE-independent polygenic risk score (PRSnon-APOE), we estimated PRSnon-APOE in superagers (age ≥ 90 years, N = 346), 89− controls (age 60–89, N = 2930), and Alzheimer's
Autor:
Sofiya Milman, Nir Barzilai, Tina Gao, Gil Atzmon, Sandra Aleksic, Jill P. Crandall, Sally Duran, Dimpi Desai, Kenny Ye
Publikováno v:
Journal of the Endocrine Society
Introduction: As life expectancy continues to increase and more men reach the extremes of age, it is important to understand the physiology of the aging hypothalamic-pituitary-testicular (HPT) axis and its role in health. While prior studies primaril
Autor:
Gil Atzmon, Nir Barzilai, P. Eline Slagboom, Fernando Macian, Ignacio Guerrero-Ros, Andrea B. Maier, Yotam Raz
Publikováno v:
Journal of Gerontology: Medical Sciences, 72(9), 1201-1206
Raz, Y, Guerrero-Ros, I, Maier, A, Slagboom, P E, Atzmon, G, Barzilai, N & Macian, F 2017, ' Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity ', The journals of gerontology. Series A : Biological sciences and medical sciences, vol. 72, no. 9, pp. 1201-1206 . https://doi.org/10.1093/gerona/glx020
The journals of gerontology. Series A : Biological sciences and medical sciences, 72(9), 1201-1206. Oxford University Press
Raz, Y, Guerrero-Ros, I, Maier, A, Slagboom, P E, Atzmon, G, Barzilai, N & Macian, F 2017, ' Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity ', The journals of gerontology. Series A : Biological sciences and medical sciences, vol. 72, no. 9, pp. 1201-1206 . https://doi.org/10.1093/gerona/glx020
The journals of gerontology. Series A : Biological sciences and medical sciences, 72(9), 1201-1206. Oxford University Press
As with many other tissues and organs, the immune system is also affected by age. Immunosenescence is characterized by a decreased ability of immune cells to mount a productive response upon exposure to new antigens. Several studies have reported tha
Autor:
Francesco Villa, Anastasia Gurinovich, Gil Atzmon, Annibale Alessandro Puca, Thomas T. Perls, Harold Bae, Aldi T. Kraja, Stacy L. Andersen, Paola Sebastiani, Nir Barzilai, Danny Ben-Avraham, Alberto Malovini
Publikováno v:
The Journals of Gerontology: Series A. 72:1453-1464
The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by investigators. To address these issues, we established a consortium of four studies of extreme longevit
Autor:
Stacy L. Andersen, Annibale Alessandro Puca, Paola Sebastiani, Nir Barzilai, Gil Atzmon, Anastasia Gurinovich
Publikováno v:
J Gerontol A Biol Sci Med Sci
APOE is a well-studied gene with multiple effects on aging and longevity. The gene has three alleles: e2, e3, and e4, whose frequencies vary by ethnicity. While the e2 is associated with healthy cognitive aging, the e4 allele is associated with Alzhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcd92a6b2349e50eb1cd41ded403fea
http://hdl.handle.net/11386/4740655
http://hdl.handle.net/11386/4740655
Autor:
Gil Atzmon, Rosalind Ramsey-Goldman, Barry J. McDonnell, Yun-Ling Zheng, David Gilley, Teresa E. Seeman, Maciej Tomaszewski, Massimo Mangino, Geja J. Hageman, Florian Kronenberg, Iiris Hovatta, Giuseppe Paolisso, Line Rode, Ellen W. Demerath, Jaakko Kaprio, Katarina Nordfjäll, Jonathan N. Hofmann, Peter Willeit, Rosana Maria dos Reis, Barbara Kollerits, Andrea Elena Iglesias Molli, Guo Cheng, Wei Zheng, Karen A. Mather, Daniel Eisenberg, Fadi J. Charchar, Sarah E. Harris, Bianca D’Antono, Jason Y.Y. Wong, Sofia Pavanello, Lisa A. Boardman, Guillaume Paré, Jacob B. H. Hjelmborg, Erik J. Giltay, Tim De Meyer, Evangelia Antoniou, Dmytro Krasnienkov, Maurice P. Zeegers, Marek Kasielski, Audrey E. Hendricks, Linda Broer, Lifang Hou, Andrew Steptoe, Andrew J. Pellatt, Jennifer A. Nettleton, Vanessa A. Diaz, Steven C. Hunt, Marij Gielen, Josine E. Verhoeven, Christian Gieger, Roxanne Schaakxs, Belinda L. Needham, Catherine Duggan, Timo E. Strandberg, Ute Mons, Klelia D. Salpea, Jeremy D. Kark, Raffaela Zannolli, Muthuswamy Balasubramanyam, Michael Chong, Richard P. Ebstein, Daniel Bunout, Amelia Marti, Kristina Sundquist, Lisa Mirabello, Hisham Nassar, David J. Kurz, Ramin Farzaneh-Far, Ilja Demuth, Pim van der Harst
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Christensen, K & TELOMAAS group 2018, ' Body mass index is negatively associated with telomere length : A collaborative cross-sectional meta-analysis of 87 observational studies ', American Journal of Clinical Nutrition, vol. 108, no. 3, pp. 453-475 . https://doi.org/10.1093/ajcn/nqy107
American Journal of Clinical Nutrition, 108(3), 453-475
Gielen, M, Hageman, G J, Antoniou, E E, Nordfjall, K, Mangino, M, Balasubramanyam, M, De Meyer, T, Hendricks, A E, Giltay, E J, Hunt, S C, Nettleton, J A, Salpea, K D, Diaz, V A, Farzaneh-far, R, Atzmon, G, Harris, S E, Hou, L, Gilley, D, Hovatta, I, Kark, J D, Nassar, H, Kurz, D J, Mather, K A, Willeit, P, Zheng, Y, Pavanello, S, Demerath, E W, Rode, L, Bunout, D, Steptoe, A, Boardman, L, Marti, A, Needham, B, Zheng, W, Ramsey-goldman, R, Pellatt, A J, Kaprio, J, Hofmann, J N, Gieger, C, Paolisso, G, Hjelmborg, J B H, Mirabello, L, Seeman, T, Wong, J, Van Der Harst, P, Broer, L, Kronenberg, F, Kollerits, B, Strandberg, T, Eisenberg, D T A, Duggan, C, Verhoeven, J E, Schaakxs, R, Zannolli, R, Dos Reis, R M R, Charchar, F J, Tomaszewski, M, Mons, U, Demuth, I, Molli, A E I, Cheng, G, Krasnienkov, D, D'antono, B, Kasielski, M, Mcdonnell, B J, Ebstein, R P, Sundquist, K, Pare, G, Chong, M & Zeegers, M P 2018, ' Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies ', The American journal of clinical nutrition, vol. 108, no. 3, pp. 453-475 . https://doi.org/10.1093/ajcn/nqy107
TELOMAAS group 2018, ' Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies ', American Journal of Clinical Nutrition, vol. 108, no. 3, pp. 453-475 . https://doi.org/10.1093/ajcn/nqy107
American Journal of Clinical Nutrition, 108(3), 453-475. Oxford University Press
American Journal of Clinical Nutrition
The American Journal of Clinical Nutrition
American Journal of Clinical Nutrition, 108(3), 453-475. American Society for Nutrition
Universidade de São Paulo (USP)
instacron:USP
Christensen, K & TELOMAAS group 2018, ' Body mass index is negatively associated with telomere length : A collaborative cross-sectional meta-analysis of 87 observational studies ', American Journal of Clinical Nutrition, vol. 108, no. 3, pp. 453-475 . https://doi.org/10.1093/ajcn/nqy107
American Journal of Clinical Nutrition, 108(3), 453-475
Gielen, M, Hageman, G J, Antoniou, E E, Nordfjall, K, Mangino, M, Balasubramanyam, M, De Meyer, T, Hendricks, A E, Giltay, E J, Hunt, S C, Nettleton, J A, Salpea, K D, Diaz, V A, Farzaneh-far, R, Atzmon, G, Harris, S E, Hou, L, Gilley, D, Hovatta, I, Kark, J D, Nassar, H, Kurz, D J, Mather, K A, Willeit, P, Zheng, Y, Pavanello, S, Demerath, E W, Rode, L, Bunout, D, Steptoe, A, Boardman, L, Marti, A, Needham, B, Zheng, W, Ramsey-goldman, R, Pellatt, A J, Kaprio, J, Hofmann, J N, Gieger, C, Paolisso, G, Hjelmborg, J B H, Mirabello, L, Seeman, T, Wong, J, Van Der Harst, P, Broer, L, Kronenberg, F, Kollerits, B, Strandberg, T, Eisenberg, D T A, Duggan, C, Verhoeven, J E, Schaakxs, R, Zannolli, R, Dos Reis, R M R, Charchar, F J, Tomaszewski, M, Mons, U, Demuth, I, Molli, A E I, Cheng, G, Krasnienkov, D, D'antono, B, Kasielski, M, Mcdonnell, B J, Ebstein, R P, Sundquist, K, Pare, G, Chong, M & Zeegers, M P 2018, ' Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies ', The American journal of clinical nutrition, vol. 108, no. 3, pp. 453-475 . https://doi.org/10.1093/ajcn/nqy107
TELOMAAS group 2018, ' Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies ', American Journal of Clinical Nutrition, vol. 108, no. 3, pp. 453-475 . https://doi.org/10.1093/ajcn/nqy107
American Journal of Clinical Nutrition, 108(3), 453-475. Oxford University Press
American Journal of Clinical Nutrition
The American Journal of Clinical Nutrition
American Journal of Clinical Nutrition, 108(3), 453-475. American Society for Nutrition
Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shorte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdf732c38593d0bc118ec9a93d2b12d
https://hdl.handle.net/1887/96085
https://hdl.handle.net/1887/96085
Autor:
Carole Oddoux, Harry Ostrer, Laurie J. Ozelius, Susan Hiraki, Philip Meyer, Itsik Pe'er, Ariel Darvasi, Inga Peter, Nir Barzilai, Lorraine N. Clark, Kinnari Upadhyay, Brett Baskovich, Jin Yu, Judy H. Cho, Shai Carmi, Todd Lencz, Gil Atzmon
Publikováno v:
Genetics in Medicine. 18:522-528
Carrier screening programs that identify the presence of known mutations have been effective for reducing the incidence of autosomal recessive conditions in the Ashkenazi Jewish (AJ) population and other populations. Yet, these programs have not real
Autor:
Takashi Sasaki, Francesco Villa, Paola Sebastiani, Gil Atzmon, Harold Bae, Nir Barzilai, Kaare Christensen, Marianne Nygaard, Yasumichi Arai, Thomas T. Perls, Lene Christiansen, Nobuyoshi Hirose, Annibale Alessandro Puca, Anastasia Gurinovich, Stacy L. Andersen, Benjamin Sweigart
Publikováno v:
Sebastiani, P, Gurinovich, A, Nygaard, M, Sasaki, T, Sweigart, B, Bae, H, Andersen, S L, Villa, F, Atzmon, G, Christensen, K, Arai, Y, Barzilai, N, Puca, A, Christiansen, L, Hirose, N & Perls, T T 2019, ' APOE Alleles and Extreme Human Longevity ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 74, no. 1, pp. 44–51 . https://doi.org/10.1093/gerona/gly174
We assembled a collection of 28,297 participants from seven studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a8a0a84b2a589d71dcec32a8cda603
https://europepmc.org/articles/PMC6298189/
https://europepmc.org/articles/PMC6298189/
Autor:
Arjun Sood, Temuri Budagov, Radhashree Maitra, Sanjay Goel, Mahadi A. Baig, Gil Atzmon, Santiago Aparo, Titto Augustine, John M. Mariadason
Publikováno v:
British Journal of Cancer
Background: Telomeres are TTAGGG tandem repeats capping chromosomal ends and partially controlled by the telomerase enzyme. The EGFR pathway putatively regulates telomerase function, prompting an investigation of telomere length (TL) and its associat