Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dashyant Dhanak"'
Autor:
Adel Giaid, Eliot H. Ohlstein, Stephen A. Douglas, Wisam Ramli, Dashyant Dhanak, Julia Pottinger, Nicolas Bousette
Publikováno v:
Peptides. 27:2919-2926
It is now well established that urotensin-II (UII) levels are increased in several cardiovascular diseases. We previously demonstrated that UII and the UII receptor (UT) protein levels are significantly increased in the hearts of both humans and rats
Publikováno v:
Journal of Molecular and Cellular Cardiology. 41:285-295
Expression of urotensin II (UII) is significantly elevated in the hearts of patients with congestive heart failure (CHF). Recent reports have also shown increased plasma levels of UII in patients with CHF, and these levels correlated with the severit
Autor:
Dashyant Dhanak
Publikováno v:
ACS Medicinal Chemistry Letters. 3:521-523
Completion of the human genome project together with continuing efforts to identify underlying genetic drivers of disease have led to tremendous advances in the discovery of novel therapeutics. In oncology, FDA approval last year of the kinase inhibi
Autor:
Aled M. Edwards, Cheryl H. Arrowsmith, Chas Bountra, Mark E. Bunnage, Marc Feldmann, Julian C. Knight, Dhavalkumar D. Patel, Panagiotis Prinos, Michael D. Taylor, Michael Sundström, Phil Barker, Dalia Barsyte, Mario H. Bengtson, Cindy Bell, Paul Bowness, Kym M. Boycott, Carolyn Buser-Doepner, Christopher L. Carpenter, Andrew J. Carr, Kirk Clark, Anuk M. Das, Dashyant Dhanak, Peter Dirks, James Ellis, Valeria R. Fantin, Christopher Flores, Edward A. Fon, Donald E. Frail, Opher Gileadi, Ronan C. O'Hagan, Trevor Howe, John T. R. Isaac, Nada Jabado, Per-Johan Jakobsson, Lars Klareskog, Stefan Knapp, Wen Hwa Lee, Evelyne Lima-Fernandes, Ingrid E. Lundberg, John Marshall, Katlin B. Massirer, Alex E. MacKenzie, Tetsuyuki Maruyama, Anke Mueller-Fahrnow, Senthil Muthuswamy, Jagdeep Nanchahal, Catherine O'Brien, Udo Oppermann, Nils Ostermann, Kevin Petrecca, Bruce G. Pollock, Viviane Poupon, Rab K. Prinjha, Saul H. Rosenberg, Guy Rouleau, Malcolm Skingle, Arthur S. Slutsky, Garth A. M. Smith, Dominique Verhelle, Hans Widmer, L. Trevor Young
Publikováno v:
Nature Reviews Drug Discovery. 14:149-150
The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies.
Autor:
Stephan, Beck, Bradley E, Bernstein, Robert M, Campbell, Joseph F, Costello, Dashyant, Dhanak, Joseph R, Ecker, John M, Greally, Jean-Pierre, Issa, Peter W, Laird, Kornelia, Polyak, Benjamin, Tycko, Peter A, Jones, Jun, Wang
Publikováno v:
Cancer Research
Recent whole-genome sequencing of thousands of human cancers has uncovered an unexpectedly large number of mutations in genes, which control the epigenome. Many of these recurrent mutations are in epigenetic writers (e.g., EZH2, DNMT3a), readers (BRD
Autor:
Duke M. Fitch, Stephen Schauer, Steven D. Knight, Zhengping Wang, Michael N. Zimmerman, Kurt R. Auger, Roman Sakowicz, Dashyant Dhanak, Han-Jie Zhou, Amita M. Chaudhari, Carrie E. Aroyan, Jeffrey T. Finer, Deping Chai, Jeffrey R. Jackson, Lance Ridgers, Luke W. Ashcraft, Seyed Ahmed, Kenneth Wood, Erin D. Hugger, Jennifer Kuo Chen Huang, Melchor V. Marin, John D. Elliott, Andrew Mcdonald, Cynthia A. Parrish, David Sutton, Ramesh Baliga, Mariela Colón, Lisa D. Belmont, Carla A. Donatelli, Nicholas D. Adams, Joelle Lorraine Burgess, Hong Jiang, Rosanna Tedesco, Bing Yao, Jianchao Wang, Kevin J. Duffy, Gustave Bergnes, Xiangping Qian, Chiu-Mei Sung, David J. Morgans, Robert A. Copeland, Bradley P. Morgan, Michael G. Darcy, Jeffrey D. Carson, Latesh Lad, Ken A. Newlander, Lusong Luo, Daniel W. Pierce, Schmidt Stanley J
Publikováno v:
ACS medicinal chemistry letters. 1(1)
Inhibition of mitotic kinesins represents a novel approach for the discovery of a new generation of anti-mitotic cancer chemotherapeutics. We report here the discovery of the first potent and selective inhibitor of centromere-associated protein E (CE
Autor:
Stephen A. Douglas, Adel Giaid, Eliot H. Ohlstein, Ghada S. Hassan, Ewa Rakowski, Dashyant Dhanak
Publikováno v:
Journal of molecular and cellular cardiology. 39(5)
Recent studies have postulated that the vasoactive peptide urotensin II (UII) plays a role in the control of vascular remodeling by inducing smooth muscle proliferation and fibroblast-mediated collagen deposition. The present study examined the expre
Autor:
Jeffrey R. Jackson, David Sutton, Lusong Luo, Steven D. Knight, Kurt R. Auger, Robert A. Copeland, G. Van Aller, Peter J. Tummino, Melody Diamond, Dashyant Dhanak
Publikováno v:
European Journal of Cancer Supplements. 6:70