Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Aviv Regev"'
Autor:
Aman Sanger, Ayshwarya Subramanian, Ziqing Lu, Raghav Avasthi, Nik Bear Brown, Evan Z. Macosko, Asa Segerstolpe, Mor Nitzan, Aviv Regev, Gabriele Scalia, Inbal Avraham-Davidi, Tommaso Biancalani, Neriman Tokcan, Meng Zhang, Xiaowei Zhuang, Sai Ma, Duccio Fanelli, Michal Lipinski, Jason D. Buenrostro, Sanja Vickovic, Charles R. Vanderburg, Lorenzo Buffoni
Publikováno v:
Nature Methods. 18:1352-1362
Charting an organs’ biological atlas requires us to spatially resolve the entire single-cell transcriptome, and to relate such cellular features to the anatomical scale. Single-cell and single-nucleus RNA-seq (sc/snRNA-seq) can profile cells compre
Autor:
Bill Gates, Jeantine Lunshof, Hakim Yadi, Luhan Yang, Tomas de Wouters, Sajith Wickramasekara, Xavier Duportet, Michelle Mc Murray Heath, Heather Dewey-Hagborg, Emily M LeProust, Jake Sherkow, Eddie Martucci, George M. Church, Arturo Elizondo, Teresa Tarragó, Neri Oxman, Leah V. Sibener, J. Craig Venter, Aviv Regev, Abasi Ene-Obong, Katrine Bosley, Francesco Gatto, Sebastian Giwa, Veronika Oudova, Sharon F. Terry, Silvia Gold, Spin Wang, Priscilla Chan, Jason Mellad, Christopher Thomas Scott, Charlotte Casebourn, Janice Chen, Sarah Richardson, Michael Chen, Bowen Zhao, Jeremy Farrar, Jernej Godec, John Cumbers
Publikováno v:
Nature Biotechnology, 39(6), 654-660. Nature Publishing Group
Nature Biotechnology asks a selection of leaders from across biotech to look at the future of the sector and make some predictions for the coming years.
Autor:
Jiarui Ding, Aviv Regev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Single-cell RNA-Seq (scRNA-seq) is invaluable for studying biological systems. Dimensionality reduction is a crucial step in interpreting the relation between cells in scRNA-seq data. However, current dimensionality reduction methods are often confou
Autor:
Federica Piccioni, Michael S. Cuoco, Aviv Regev, Vincent A. Miller, Samuel S. Freeman, Nan Lin, Nikhil Wagle, Seth A. Wander, Kailey J. Kowalski, David E. Root, Pingping Mao, Jon Chung, Adrienne G. Waks, Eric P. Winer, Utthara Nayar, Orit Rozenblatt-Rosen, Justin Kusiel, Ofir Cohen, Jorge E. Buendia-Buendia, Pedro Exman
Publikováno v:
Clinical Cancer Research. 26:5974-5989
Purpose:To identify clinically relevant mechanisms of resistance to ER-directed therapies in ER+ breast cancer.Experimental Design:We conducted a genome-scale functional screen spanning 10,135 genes to investigate genes whose overexpression confer re
Autor:
Vamsi K. Mootha, Amel Karaa, Caleb A. Lareau, Leif S. Ludwig, Vijay G. Sankaran, Aviv Regev, Melissa A. Walker
Publikováno v:
N Engl J Med
Many mitochondrial diseases are caused by mutations in mitochondrial DNA (mtDNA). Patients' cells contain a mixture of mutant and nonmutant mtDNA (a phenomenon called heteroplasmy). The proportion of mutant mtDNA varies across patients and among tiss
Autor:
Aviv Regev, Orr Ashenberg, Marcin Tabaka, Yanay Rosen, Joshua Gould, Nir Hacohen, Bo Li, Yiming Yang, Siranush Sarkizova, Michal Slyper, Alexandra-Chloé Villani, Monika S. Kowalczyk, Orit Rozenblatt-Rosen, Timothy L. Tickle
Publikováno v:
Nature methods
Massively parallel single-cell and single-nucleus RNA sequencing has opened the way to systematic tissue atlases in health and disease, but as the scale of data generation is growing, so is the need for computational pipelines for scaled analysis. He
Autor:
Tyler Burks, Jiarui Ding, Shaina Carroll, Lan T. Nguyen, Shuqiang Li, Travis K. Hughes, Boaz Barak, Joshua Z. Levin, Alex K. Shalek, William Ge, Xian Adiconis, Nir Hacohen, John Y. Kwon, Sean Simmons, Aviv Regev, Nemanja D. Marjanovic, Cynthia C. Hession, Alexandra-Chloé Villani, Monika S. Kowalczyk, Orit Rozenblatt-Rosen, Marc H. Wadsworth, Amanda J. Kedaigle
Publikováno v:
Nature Biotechnology. 38:737-746
The scale and capabilities of single-cell RNA-sequencing methods have expanded rapidly in recent years, enabling major discoveries and large-scale cell mapping efforts. However, these methods have not been systematically and comprehensively benchmark
Autor:
Michael Kann, Stefanie R. Bailey, Amanda A. Bouffard, Irene Scarfò, Max Jan, Julia Joung, Travis Law, Mark B. Leick, Gad Getz, Tamara Ouspenskaia, Rebecca C. Larson, Nicholas J. Haradhvala, Marcela V. Maus, Aviv Regev, Kai Stewart, Trisha R. Berger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundChimeric Antigen Receptor (CAR) therapy has had a transformative impact on the treatment of hematologic malignancies1–6 but success in solid tumors remains elusive. We hypothesized solid tumors have cell-intrinsic resistance mechanisms to
Autor:
Jason M. Schenkel, Prajan Divakar, Alex M. Jaeger, Ana P. Garcia, Peter M. K. Westcott, Tyler Hether, Zackery A. Ely, Roderick T. Bronson, Laurens J. Lambert, Jason Reeves, William A. Freed-Pastor, Devan Phillips, Vikram Deshpande, Arjun Bhutkar, Kim L. Mercer, Ömer H. Yilmaz, Tyler Jacks, George Eng, Lin Lin, William L. Hwang, Nimisha B. Pattada, Aviv Regev, Toni Delorey, William M. Rideout
Publikováno v:
Cancer Cell
Summary The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-based strategies to combat this disease have been largely unsuccessf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b53f9987c16263228fdea161ccfed14
https://europepmc.org/articles/PMC8511341/
https://europepmc.org/articles/PMC8511341/
Autor:
Placido D, Antell G, Bo Yuan, Elizabeth Andrews, Amalie Dahl Haue, Brian M. Wolpin, Michael H. Rosenthal, Alexandra Franz, Chris Sander, P. Kraft, Søren Brunak, Jeong Jun Kim, Jessica X. Hjaltelin, Aviv Regev, Chowdhury A, Raffaella Pizzolato Umeton, Chen Yuan, Lauren K. Brais
Pancreatic cancer is an aggressive disease that typically presents late with poor patient outcomes. There is a pronounced medical need for early detection of pancreatic cancer, which can be addressed by identifying high-risk populations. Here we appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ec1f300cd8cb3fde90a3df8c53f253
https://doi.org/10.1101/2021.06.27.449937
https://doi.org/10.1101/2021.06.27.449937