Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Tobias Pischon"'
Autor:
Matthias Laudes, Corinna Geisler, Nathalie Rohmann, Kristina Schlicht, Tobias Pischon, Jildau Bouwman
Publikováno v:
Nutrients, Vol 13, Iss 3866, p 3866 (2021)
Nutrients
Nutrients
Within the last two decades tremendous efforts in biomedicine have been undertaken to understand the interplay of commensal bacteria living in and on our human body with our own human physiology. It became clear that (1) a high diversity especially o
Autor:
Daniela Weber, Tobias Pischon, Marta Stelmach-Mardas, Wolfgang Bernigau, Heiner Boeing, Manuela M. Bergmann, Raskit Lachmann
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223449 (2019)
PLoS ONE
PLoS ONE
The advancing age of the participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study was the incentive to investigate frailty as a major parameter of ageing. The aim of this study was to develop a multidimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b75d14e2cdabd55d2c259e40668f6ff
http://edoc.mdc-berlin.de/18478/7/18478suppl.zip
http://edoc.mdc-berlin.de/18478/7/18478suppl.zip
Autor:
Anna Floegel, Wolfgang Otto, Heiner Boeing, Tobias Pischon, Cornelia Weikert, Thomas Illig, Ulrike Rolle-Kampczyk, Jerzy Adamski, Tilman Kühn, Disorn Sookthai, Theron Johnson, Martin von Bergen, Cornelia Prehn, Rudolf Kaaks
Publikováno v:
European Journal of Epidemiology
European journal of epidemiology, 33(1): 55-66
Floegel, A, Kuhn, T, Sookthai, D, Johnson, T, Prehn, C, Rolle-Kampczyk, U, Otto, W, Weikert, C, Illig, T, von Bergen, M, Adamski, J, Boeing, H, Kaaks, R & Pischon, T 2018, ' Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts ', European Journal of Epidemiology, vol. 33, no. 1, pp. 55-66 . https://doi.org/10.1007/s10654-017-0333-0
Floegel, A, Kühn, T, Sookthai, D, Johnson, T, Prehn, C, Rolle-Kampczyk, U, Otto, W, Weikert, C, Illig, T, von Bergen, M, Adamski, J, Boeing, H, Kaaks, R & Pischon, T 2018, ' Serum metabolites and risk of myocardial infarction and ischemic stroke : a targeted metabolomic approach in two German prospective cohorts ', European Journal of Epidemiology, vol. 33, no. 1, pp. 55-66 . https://doi.org/10.1007/s10654-017-0333-0
Eur. J. Epidemiol. 33, 55–66 (2018)
European journal of epidemiology, 33(1): 55-66
Floegel, A, Kuhn, T, Sookthai, D, Johnson, T, Prehn, C, Rolle-Kampczyk, U, Otto, W, Weikert, C, Illig, T, von Bergen, M, Adamski, J, Boeing, H, Kaaks, R & Pischon, T 2018, ' Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts ', European Journal of Epidemiology, vol. 33, no. 1, pp. 55-66 . https://doi.org/10.1007/s10654-017-0333-0
Floegel, A, Kühn, T, Sookthai, D, Johnson, T, Prehn, C, Rolle-Kampczyk, U, Otto, W, Weikert, C, Illig, T, von Bergen, M, Adamski, J, Boeing, H, Kaaks, R & Pischon, T 2018, ' Serum metabolites and risk of myocardial infarction and ischemic stroke : a targeted metabolomic approach in two German prospective cohorts ', European Journal of Epidemiology, vol. 33, no. 1, pp. 55-66 . https://doi.org/10.1007/s10654-017-0333-0
Eur. J. Epidemiol. 33, 55–66 (2018)
Metabolomic approaches in prospective cohorts may offer a unique snapshot into early metabolic perturbations that are associated with a higher risk of cardiovascular diseases (CVD) in healthy people. We investigated the association of 105 serum metab
Autor:
Christina Bamia, Krasimira Aleksandrova, Bodil Ohlsson, Heiner Boeing, Eva Ardanaz, Elio Riboli, Antonia Trichopoulou, Carlo La Vecchia, Tilman Kühn, Pietro Ferrari, Francesca Fasanelli, Elisabete Weiderpass, Oskar Hemmingsson, Aurora Perez-Cornago, Franck Carbonnel, Heather Ward, Roel Vermeulen, Anne M. May, Mazda Jenab, Sebastian E. Baumeister, Michael F. Leitzmann, Heinz Freisling, María Dolores López, Sara Grioni, Kim Overvad, Carmen Jochem, Sunday Oluwafemi Oyeyemi, Kristin Benjaminsen Borch, Bas Bueno de Mesquita, Giovanna Masala, Mireia Felez-Nobrega, Marie-Christine Boutron-Ruault, Salvatore Panico, Tobias Pischon, Anne Tjønneland, Magdalena Stepien, Sabrina Schlesinger, Konstantinos K. Tsilidis, Agnès Fournier, Rosario Tumino, Mårten Werner, Miguel Rodríguez-Barranco, Rudolf Kaaks, Marc J. Gunter, Emily Sonestedt
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Hepatology, 70(5), 885. Elsevier
Baumeister, S E, Schlesinger, S, Aleksandrova, K, Jochem, C, Jenab, M, Gunter, M J, Overvad, K, Tjønneland, A, Boutron-Ruault, M-C, Carbonnel, F, Fournier, A, Kuehn, T, Kaaks, R, Pischon, T, Boeing, H, Trichopoulou, A, Bamia, C, La Vecchia, C, Masala, G, Panico, S, Fasanelli, F, Tumino, R, Grioni, S, de Mesquita, B B, Vermeulen, R, May, A M, Borch, K B, Oyeyemi, S O, Ardanaz, E, Rodriguez-Barranco, M, Chirlaque Lopez, M D, Felez-Nobrega, M, Sonestedt, E, Ohlsson, B, Hemmingsson, O, Werner, M, Perez-Cornago, A, Ferrari, P, Stepien, M, Freisling, H, Tsilidis, K K, Ward, H, Riboli, E, Weiderpass, E & Leitzmann, M F 2019, ' Association between physical activity and risk of hepatobiliary cancers : A multinational cohort study ', Journal of Hepatology, vol. 70, no. 5, pp. 885-892 . https://doi.org/10.1016/j.jhep.2018.12.014
Baumeister, S E, Schlesinger, S, Aleksandrova, K, Jochem, C, Jenab, M, Gunter, M J, Overvad, K, Tjønneland, A, Boutron-Ruault, M-C, Carbonnel, F, Fournier, A, Kühn, T, Kaaks, R, Pischon, T, Boeing, H, Trichopoulou, A, Bamia, C, La Vecchia, C, Masala, G, Panico, S, Fasanelli, F, Tumino, R, Grioni, S, de Mesquita, B B, Vermeulen, R, May, A M, Borch, K B, Oyeyemi, S O, Ardanaz, E, Rodríguez-Barranco, M, López, M D C, Felez-Nobrega, M, Sonestedt, E, Ohlsson, B, Hemmingsson, O, Werner, M, Perez-Cornago, A, Ferrari, P, Stepien, M, Freisling, H, Tsilidis, K K, Ward, H, Riboli, E, Weiderpass, E & Leitzmann, M F 2019, ' Association between Physical Activity and Risk of Hepatobiliary Cancers : A Multinational Cohort Study ', Journal of Hepatology, vol. 70, no. 5, pp. 885-892 . https://doi.org/10.1016/j.jhep.2018.12.014
Universidad de Barcelona
Journal of Hepatology, 70(5), 885. Elsevier
Baumeister, S E, Schlesinger, S, Aleksandrova, K, Jochem, C, Jenab, M, Gunter, M J, Overvad, K, Tjønneland, A, Boutron-Ruault, M-C, Carbonnel, F, Fournier, A, Kuehn, T, Kaaks, R, Pischon, T, Boeing, H, Trichopoulou, A, Bamia, C, La Vecchia, C, Masala, G, Panico, S, Fasanelli, F, Tumino, R, Grioni, S, de Mesquita, B B, Vermeulen, R, May, A M, Borch, K B, Oyeyemi, S O, Ardanaz, E, Rodriguez-Barranco, M, Chirlaque Lopez, M D, Felez-Nobrega, M, Sonestedt, E, Ohlsson, B, Hemmingsson, O, Werner, M, Perez-Cornago, A, Ferrari, P, Stepien, M, Freisling, H, Tsilidis, K K, Ward, H, Riboli, E, Weiderpass, E & Leitzmann, M F 2019, ' Association between physical activity and risk of hepatobiliary cancers : A multinational cohort study ', Journal of Hepatology, vol. 70, no. 5, pp. 885-892 . https://doi.org/10.1016/j.jhep.2018.12.014
Baumeister, S E, Schlesinger, S, Aleksandrova, K, Jochem, C, Jenab, M, Gunter, M J, Overvad, K, Tjønneland, A, Boutron-Ruault, M-C, Carbonnel, F, Fournier, A, Kühn, T, Kaaks, R, Pischon, T, Boeing, H, Trichopoulou, A, Bamia, C, La Vecchia, C, Masala, G, Panico, S, Fasanelli, F, Tumino, R, Grioni, S, de Mesquita, B B, Vermeulen, R, May, A M, Borch, K B, Oyeyemi, S O, Ardanaz, E, Rodríguez-Barranco, M, López, M D C, Felez-Nobrega, M, Sonestedt, E, Ohlsson, B, Hemmingsson, O, Werner, M, Perez-Cornago, A, Ferrari, P, Stepien, M, Freisling, H, Tsilidis, K K, Ward, H, Riboli, E, Weiderpass, E & Leitzmann, M F 2019, ' Association between Physical Activity and Risk of Hepatobiliary Cancers : A Multinational Cohort Study ', Journal of Hepatology, vol. 70, no. 5, pp. 885-892 . https://doi.org/10.1016/j.jhep.2018.12.014
Accepted manuscript version, licensed CC BY-NC-ND 4.0. Background & Aims - To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3d7bfb4423fe21145cd1fd9492ce81
https://hdl.handle.net/10037/18403
https://hdl.handle.net/10037/18403
Autor:
Tobias Pischon, Marc J. Gunter, Anne Tjønneland, Kay-Tee Khaw, Heiner Boeing, Bas Bueno-de-Mesquita, Amalia Mattiello, Isabelle Romieu, Agnetha Linn Rostgaard-Hansen, Elio Riboli, Pagona Lagiou, Sabrina Schlesinger, Heinz Freisling, Kathryn E. Bradbury, Krasimira Aleksandrova, Rudolf Kaaks, Claudia Agnoli, Kim Overvad, Mazda Jenab, Veronika Fedirko, Christina C. Dahm, Christina Bamia, Antonia Trichopoulou
Publikováno v:
Aleksandrova, K, Schlesinger, S, Fedirko, V, Jenab, M, Bueno-de-Mesquita, B, Freisling, H, Romieu, I, Pischon, T, Kaaks, R, Gunter, M J, Dahm, C C, Overvad, K, Rostgaard-Hansen, A L, Tjønneland, A, Trichopoulou, A, Bamia, C, Lagiou, P, Agnoli, C, Mattiello, A, Bradbury, K, Khaw, K-T, Riboli, E & Boeing, H 2017, ' Metabolic Mediators of the Association Between Adult Weight Gain and Colorectal Cancer : Data From the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort ', American Journal of Epidemiology, vol. 185, no. 9, pp. 751-764 . https://doi.org/10.1093/aje/kww194
Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3eace30d371e78f78f33a85c6a2ffc1
http://hdl.handle.net/10029/621219
http://hdl.handle.net/10029/621219
Autor:
Catalina Bonet, Antonia Trichopoulou, Dagmar Drogan, Tilman Kühn, Elisabete Weiderpass, Dagfinn Aune, Pagona Lagiou, Elio Riboli, Kim Overvad, Rosario Tumino, Kay-Tee Khaw, Miren Dorronsoro, María José Sánchez, A. M. May, Marion Carayol, Elissavet Valanou, Christina C. Dahm, Kristin Benjaminsen Borch, Christina Bamia, Marie Christine Bouton-Ruault, Krasimira Aleksandrova, Tobias Pischon, Patrik Wennberg, Aurelio Barricarte, Rudolf Kaaks, Heather Ward, Sunday Oluwafemi Oyeyemi, Nada Assi, Eleni Peppa, Domenico Palli, Bethany Van Guelpen, Mazda Jenab, Anne Tjønneland, Jonna K. van Vulpen, Timothy J. Key, Sabina Rinaldi, Heiner Boeing, Paula Jakszyn, Heinz Freisling, Carmen Navarro, Salvatore Panico, Carlo La Vecchia, J. Ramón Quirós, Claudia Agnoli, Nicholas J. Wareham, Bas Bueno-de-Mesquita, Carlotta Sacerdote, Michael F. Leitzmann
Publikováno v:
Aleksandrova, K, Jenab, M, Leitzmann, M, Bueno-de-Mesquita, B, Kaaks, R, Trichopoulou, A, Bamia, C, Lagiou, P, Rinaldi, S, Freisling, H, Carayol, M, Pischon, T, Drogan, D, Weiderpass, E, Jakszyn, P, Overvad, K, Dahm, C C, Tjønneland, A, Bouton-Ruault, M-C, Kühn, T, Peppa, E, Valanou, E, La Vecchia, C, Palli, D, Panico, S, Sacerdote, C, Agnoli, C, Tumino, R, May, A, van Vulpen, J, Benjaminsen Borch, K, Oluwafemi Oyeyemi, S, Quirós, J R, Bonet, C, Sánchez, M-J, Dorronsoro, M, Navarro, C, Barricarte, A, van Guelpen, B, Wennberg, P, Key, T J, Khaw, K-T, Wareham, N, Assi, N, Ward, H A, Aune, D, Riboli, E & Boeing, H 2017, ' Physical activity, mediating factors and risk of colon cancer : insights into adiposity and circulating biomarkers from the EPIC cohort ', International Journal of Epidemiology, vol. 46, no. 6, pp. 1823-1835 . https://doi.org/10.1093/ije/dyx174
International Journal of Epidemiology, 46(6), 1823. Oxford University Press
International Journal of Epidemiology, 46(6), 1823. Oxford University Press
Background: There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170b31d1eec727fd212fab800fe37d25
https://pure.au.dk/portal/da/publications/physical-activity-mediating-factors-and-risk-of-colon-cancer(39d41eb9-78b9-45fd-9f6b-f4f644f82de4).html
https://pure.au.dk/portal/da/publications/physical-activity-mediating-factors-and-risk-of-colon-cancer(39d41eb9-78b9-45fd-9f6b-f4f644f82de4).html
Autor:
H. Boeing, Krasimira Aleksandrova, Christina C. Dahm, Sabrina Schlesinger, Tobias Pischon, Veronika Fedirko, Ute Nöthlings, Manja Koch, Wolfgang Lieb
Publikováno v:
Obesity Reviews. 16:607-619
While the relationship between body mass index as an indicator of excess body weight and the risk of colorectal cancer (CRC) is well established, the association between body weight gain in adulthood and risk of CRC remains unresolved. We quantified
Autor:
Katharina Nimptsch, Gianluca Severi, Young-Ae Lee, Ruth C. Travis, Antonia Trichopoulou, Konstantinos K. Tsilidis, Hendrik B. Bueno-de-Mesquita, Domenico Palli, Kay-Tee Khaw, Heiner Boeing, Verena Katzke, Dimitrios Trichopoulos, Marie-Christine Boutron-Ruault, Miren Dorronsoro, Juergen Janke, Elisabete Weiderpass, Rosario Tumino, Nicholas J. Wareham, Amalia Mattiello, Hanna Nyström, José Ramón Quirós, Kim Overvad, Pagona Lagiou, Aurelio Barricarte Gurrea, Antoine Racine, María Dolores Chirlaque, Sara Grioni, Anne Tjønneland, Jenny Brändstedt, Tobias Pischon, María José Sánchez, Ingrid Ljuslinder, Heinz Freisling, Mazda Jenab, Eugene Jansen, Elio Riboli, Chunsen Wu, Catalina Bonet, Krasimira Aleksandrova, Petra H.M. Peeters, Anja Olsen, So Yeon Kong, Marc J. Gunter, Rudolf Kaaks, Alessio Naccarati, Peter D. Siersema
Publikováno v:
International Journal of Cancer. 137:911-920
Fetuin-A, also referred to as alpha 2-Heremans-Schmid glycoprotein (AHSG), is a liver protein known to inhibit insulin actions. Hyperinsulinemia is a possible risk factor for colorectal cancer; however, the role of fetuin-A in the development of colo
Autor:
Kim Overvad, J. Ramón Quirós, Eva Ardanaz, Salvatore Panico, Rosario Tumino, Marc J. Gunter, Antoine Racine, María Dolores Chirlaque, Peter Wallström, Anne Tjønneland, Anna Floegel, Heiner Boeing, Vasiliki Benetou, Cuno S.P.M. Uiterwaal, Kay-Tee Khaw, Malin Sund, Ruth C. Travis, Christina Bamia, Esther Molina-Montes, Marie-Christine Boutron-Ruault, Pagona Lagiou, Sara Grioni, Dimitrios Trichopoulos, Tobias Pischon, Nicholas J. Wareham, Magdalena Stepien, Björn Lindkvist, Nirmala Bhoo-Pathy, Guy Fagherazzi, Miren Dorronsoro, Pietro Ferrari, Elisabete Weiderpass, Veronika Fedirko, Eiliv Lund, Paolo Vineis, Tilman Kühn, Hendrik B. Bueno-de-Mesquita, Domenico Palli, Kathryn E. Bradbury, Talita Duarte-Salles, Neil Murphy, Antonia Trichopoulou, Krasimira Aleksandrova, Anja Olsen, Mazda Jenab, Elio Riboli, Raul Zamora-Ros, Vincent K. Dik, Lena Maria Nilsson
Publikováno v:
International Journal of Cancer. 136:1899-1908
Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospe
Autor:
Dawn Q. Chong, Catalina Bonet, Edward Giovannucci, Katharina Nimptsch, Marc J. Gunter, Andrew T. Chan, Michail Katsoulis, Gianluca Severi, Karin Jirström, Sabina Sieri, Miguel Rodríguez-Barranco, Shuji Ogino, Charles S. Fuchs, Ruth C. Travis, Young-Ae Lee, José María Huerta, Mingyang Song, Mazda Jenab, Salvatore Panico, H. Bas Bueno-de-Mesquita, Miren Dorronsoro, Bethany Van Guelpen, José Ramón Quirós, Heinz Freisling, Kim Overvad, Eric B. Rimm, Chunsen Wu, Olle Melander, Majken K. Jensen, Elisabete Weiderpass, Elio Riboli, Heiner Boeing, Franck Carbonnel, Anne Tjønneland, Kana Wu, Marie-Christine Boutron-Ruault, Tilman Kühn, Myrto Barrdahl, Amanda J. Cross, Petra H.M. Peeters, Anja Olsen, Krasimira Aleksandrova, Robin Myte, Tobias Pischon, Domenico Palli, Konstantinos K. Tsilidis, Jürgen Janke
Publikováno v:
Nimptsch, K, Song, M, Aleksandrova, K, Katsoulis, M, Freisling, H, Jenab, M, Gunter, M J, Tsilidis, K K, Weiderpass, E, Bueno-de-Mesquita, H B, Chong, D Q, Jensen, M K, Wu, C, Overvad, K, Kühn, T, Barrdahl, M, Melander, O, Jirström, K, Peeters, P H M, Sieri, S, Panico, S, Cross, A J, Riboli, E, Van Guelpen, B, Myte, R, Huerta, J M, Rodriguez-Barranco, M, Quirós, J R, Dorronsoro, M, Tjønneland, A, Olsen, A, Travis, R, Boutron-Ruault, M-C, Carbonnel, F, Severi, G, Bonet, C B, Palli, D, Janke, J, Lee, Y-A, Boeing, H, Giovannucci, E L, Ogino, S, Fuchs, C S, Rimm, E B, Wu, K, Chan, A T & Pischon, T 2017, ' Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer : a Mendelian Randomization analysis using data from three large cohort studies ', European Journal of Epidemiology, vol. 32, no. 5, pp. 419–430 . https://doi.org/10.1007/s10654-017-0262-y
Nimptsch, K, Song, M, Aleksandrova, K, Katsoulis, M, Freisling, H, Jenab, M, Gunter, M J, Tsilidis, K, Weiderpass, E, Bueno-de-Mesquita, H B, Chong, D Q, Jensen, M K, Wu, C, Overvad, K, Kühn, T, Barrdahl, M, Melander, O, Jirström, K, Peeters, P H, Sieri, S, Panico, S, Cross, A J, Riboli, E, Van Guelpen, B, Myte, R, Huerta, J M, Rodríguez-Barranco, M, Quirós, J R, Dorronsoro, M, Tjønneland, A, Olsen, A, Travis, R, Boutron-Ruault, M-C, Carbonnel, F, Severi, G, Bonet, C, Palli, D, Janke, J, Lee, Y-A, Boeing, H, Giovannucci, E L, Ogino, S, Fuchs, C S, Rimm, E, Wu, K, Chan, A T & Pischon, T 2017, ' Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer : a Mendelian Randomization analysis using data from three large cohort studies ', European Journal of Epidemiology, vol. 32, no. 5, pp. 419-430 . https://doi.org/10.1007/s10654-017-0262-y
European Journal of Epidemiology, 32(5), 419. Springer Netherlands
Nimptsch, K, Song, M, Aleksandrova, K, Katsoulis, M, Freisling, H, Jenab, M, Gunter, M J, Tsilidis, K, Weiderpass, E, Bueno-de-Mesquita, H B, Chong, D Q, Jensen, M K, Wu, C, Overvad, K, Kühn, T, Barrdahl, M, Melander, O, Jirström, K, Peeters, P H, Sieri, S, Panico, S, Cross, A J, Riboli, E, Van Guelpen, B, Myte, R, Huerta, J M, Rodríguez-Barranco, M, Quirós, J R, Dorronsoro, M, Tjønneland, A, Olsen, A, Travis, R, Boutron-Ruault, M-C, Carbonnel, F, Severi, G, Bonet, C, Palli, D, Janke, J, Lee, Y-A, Boeing, H, Giovannucci, E L, Ogino, S, Fuchs, C S, Rimm, E, Wu, K, Chan, A T & Pischon, T 2017, ' Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer : a Mendelian Randomization analysis using data from three large cohort studies ', European Journal of Epidemiology, vol. 32, no. 5, pp. 419-430 . https://doi.org/10.1007/s10654-017-0262-y
European Journal of Epidemiology, 32(5), 419. Springer Netherlands
This is a pre-print of an article published in European Journal of Epidemiology. The final authenticated version is available online at: https://doi.org/10.1007/s10654-017-0262-y. Higher levels of circulating adiponectin have been related to lower ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2dceb54026dc70ddab1926e685da96c
https://hdl.handle.net/10037/13752
https://hdl.handle.net/10037/13752