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Publikováno v:
Alcoholism: Clinical and Experimental Research. 39:2022-2031
Background The P2X4 receptor (P2X4R) is thought to be involved in regulating alcohol-consuming behaviors, and ethanol (EtOH) has been reported to inhibit P2X4Rs. Ivermectin is an antiparasitic agent that acts as a positive allosteric modulator of the
Publikováno v:
Psychopharmacology. 214:941-947
The monoamine reuptake inhibitor sibutramine reduces food intake but the receptor subtypes mediating the effects of sibutramine on feeding remain to be clearly identified.The involvement of the 5-HT(2C) receptor subtype in the satiety-enhancing effec
Autor:
Shinya Tosaka, Shuhei Matsumoto, Tetsuya Hara, Takuji Maekawa, Hiroyuki Ureshino, Koji Sumikawa, Sungsam Cho
Publikováno v:
Cardiovascular Drugs and Therapy. 23(4):263-270
PURPOSE: The authors examined whether olprinone, a phosphodiesterase type 3 inhibitor, or isoflurane, a volatile anesthetic, could protect the heart against myocardial infarction in type 2 diabetic rats and whether the underlying mechanisms involve p
Autor:
Henrik Wie, Eva Imislund Beck
Publikováno v:
Acta Pharmacologica et Toxicologica. 48:294-299
The metabolism of collagen and mineral was studied during a nine-day postmedicational period in young, male rats receiving high-dose intraperitoneal cyclophosphamide treatment every second day for 12 days. Two days after ending medication the white b
Publikováno v:
Acta Pharmacologica et Toxicologica. 52:90-94
Chronic ingestion of ethanol (5 g/kg/day)for 6 weeks increased the hepatotoxicity of a single injection of D-galactosamine (330 mg/kg) in rats. Plasma transaminases, alkaline phosphatase, gamma glutamyl transpeptidase and sulphobromophthalein retenti
Autor:
Aage Theil Nielsen
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:321-328
The anaphylactic contraction (Schultz-Dale response) of the isolated uterus from actively sensitized rats was partially suppressed by methysergide, 1.5 mug/ml. Although the inhibitory effect of indomethacin, 3.5 mug/ml, was only slight, the combinati
Publikováno v:
Acta Pharmacologica et Toxicologica. 55:270-277
Intravenous injection of soman in the rat produced a rapid and dose related increase in blood pressure. The dose response curve was very steep, threshold responses occurring after intravenous injection of 10 micrograms/kg, and maximum increases of ab
Autor:
Leena A. Hilakivi
Publikováno v:
Acta Pharmacologica et Toxicologica. 59:36-42
Our previous experiments showed that suppression of early postnatal active (REM) sleep increases alcohol intake in adult rats. To study the effects of prenatal alcohol exposure on neonatal sleep-wake behaviour and adult alcohol consumption pregnant r
Autor:
Debabrata Chanda, Karuna Shanker, Mahendra P. Darokar, Suaib Luqman, Dayanandan Mani, Dnyaneshwar U. Bawankule, Anirban Pal
Publikováno v:
The Journal of Toxicological Sciences. 34:99-108
Chemical characterization and acute and sub-acute toxicity study of Trikatu, a generic herbal formulation of Indian system of medicine, was carried out in Charles Foster (CF) rats for safety profiling. In acute toxicity experiment, Trikatu at 2,000 m
Publikováno v:
American Journal of Nephrology. 28:8-13
Background/Aims: There are two major pathophysiologic processes involved in the development of hypertension: (1) expanded extracellular fluid volume and (2) vasoconstriction. We have developed a model of preeclampsia in the rat, in which excessive vo