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pro vyhledávání: '"William C. Hunter"'
Publikováno v:
Circulation. 86:1945-1954
BACKGROUND Most positive inotropic agents increase cardiac contractility by increasing the amount of Ca2+ cycled with each beat. The additional amount of oxygen that is consumed by the heart to cycle this additional Ca2+ is believed to reduce myocard
Autor:
S Bier, D. Burkhoff, William C. Hunter, Matthew R. Wolff, David A. Kass, Y Harasawa, Gary Gerstenblith, P. P. De Tombe
Publikováno v:
Circulation Research. 70:516-529
The contributions of changes in primary systolic and diastolic properties, limitations of contractile reserve, and alterations in energy efficiency to the left ventricular dysfunction seen with chronic pacing tachycardia were investigated. Seven dogs
Publikováno v:
Circulation. 73:938-950
Dimension change measures of regional ventricular function, such as absolute or percent wall thickening (delta T or % delta T) or segmental shortening (delta L or % delta L), are highly load dependent. In 16 anesthetized mongrel dogs we assessed use
Publikováno v:
Circulation. 72:654-659
Although the rate dependence of isolated muscle contractility is well known, the ventricular end-systolic pressure-volume relationship (ESPVR) has been reported to be insensitive to heart rate. To resolve this contradiction, we used an isolated, ejec