Zobrazeno 1 - 10
of 11
pro vyhledávání: '"William C. Hunter"'
Autor:
Jerome P. Trzeciakowski, William C. Hunter, Nancy L. Sehgel, Zhongkui Hong, Yi Zhu, Stephen F. Vatner, Zhe Sun, Dorothy E. Vatner, Gerald A. Meininger
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H1281-H1287
Increased vascular stiffness is fundamental to hypertension, and its complications, including atherosclerosis, suggest that therapy should also be directed at vascular stiffness, rather than just the regulation of peripheral vascular resistance. It i
Autor:
William C. Hunter
Publikováno v:
Cardiology Clinics. 18:443-457
Myocardial relaxation is governed by the interplay of two macromolecular systems: (1) myofilaments and (2) calcium extruding pumps/exchangers. In myocardium from failing hearts, both systems act more slowly than normal, and cause relaxation to decele
Publikováno v:
Journal of the American College of Cardiology. 33(6):1735-1742
Asynchronous electrical activation of the ventricles, as during left bundle branch block (LBBB) and during ventricular pacing, is associated with abnormal, locally different contraction patterns (1-3) and deficiencies in perfusion and glucose uptake
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 272:H469-H477
Previous studies of regional differences in myocardial deformation between the anterior and posterior walls of the canine left ventricle were based on strain, which is not an absolute measure of deformation. We thus compared sarcomere lengths at ante
Publikováno v:
Circulation. 86:1945-1954
BACKGROUND Most positive inotropic agents increase cardiac contractility by increasing the amount of Ca2+ cycled with each beat. The additional amount of oxygen that is consumed by the heart to cycle this additional Ca2+ is believed to reduce myocard
Autor:
S Bier, D. Burkhoff, William C. Hunter, Matthew R. Wolff, David A. Kass, Y Harasawa, Gary Gerstenblith, P. P. De Tombe
Publikováno v:
Circulation Research. 70:516-529
The contributions of changes in primary systolic and diastolic properties, limitations of contractile reserve, and alterations in energy efficiency to the left ventricular dysfunction seen with chronic pacing tachycardia were investigated. Seven dogs
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H1596-H1611
Understanding the relationship between structure and function in the heart requires a knowledge of the connection between the local behavior of the myocardium (e.g., shortening) and the pumping action of the left ventricle. We asked the question, how
Publikováno v:
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. 5(4)
The effects of different pacing protocols on left ventricular (LV) torsion were evaluated over the full cardiac cycle. A systolic and diastolic series of magnetic resonance imaging (MRI) scans were combined and used to calculate the torsion of the LV
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 282(1)
Resynchronization is frequently used for the treatment of heart failure, but the mechanism for improvement is not entirely clear. In the present study, the temporal synchrony and spatiotemporal distribution of left ventricular (LV) contraction was in
Publikováno v:
The American journal of physiology. 265(3 Pt 2)
This study focuses on elucidating how ventricular afterloading conditions affect the time course of change of left ventricular pressure (LVP) throughout the cardiac cycle, with particular emphasis on revealing specific limitations in the time-varying