Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Judith E. Allen"'
Autor:
Benjamin H. Maskrey, Mark Blaxter, Phillip D. Whitfield, Graham D. Thomas, Dominik Rückerl, Judith E. Allen
Publikováno v:
Blood. 120:e93-e104
Alternatively activated macrophages (AAMφ) are a major component of the response to helminth infection; however, their functions remain poorly defined. To better understand the helminth-induced AAMφ phenotype, we performed a systems-level analysis
Publikováno v:
Parasite Immunology. 34:243-253
Filarial infections remain a major public health and socio-economic problem across the tropics, despite considerable effort to reduce disease burden or regionally eliminate the infection with mass drug administration programmes. The sustainability of
Autor:
Lucy H. Jones, Stephen J. Jenkins, Judith E. Allen, Nico van Rooijen, Peter C. Cook, Andrew S. MacDonald, Dominik Rückerl, Fred D. Finkelman
Publikováno v:
Jenkins, S J, Ruckerl, D, Cook, P C, Jones, L H, Finkelman, F D, van Rooijen, N, MacDonald, A S & Allen, J E 2011, ' Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of T(H)2 Inflammation ', Science, vol. 332, no. 6035, pp. 1284-1288 . https://doi.org/10.1126/science.1204351
Science, 332(6035), 1284-1288. American Association for the Advancement of Science
Science, 332(6035), 1284-1288. American Association for the Advancement of Science
A defining feature of inflammation is the accumulation of innate immune cells in the tissue that are thought to be recruited from the blood. We reveal that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in o
Autor:
Judith E. Allen, Robert N. Barker, Andrew J. Rees, Heather M. Wilson, Dominik Rückerl, Silvia Gaspar-Pereira, Claire S. Whyte, E. T. Bishop
Publikováno v:
Journal of Leukocyte Biology. 90:845-854
Macrophages become activated by their environment and develop polarized functions: classically activated (M1) macrophages eliminate pathogens but can cause tissue injury, whereas alternatively activated (M2) macrophages promote healing and repair. Me
Publikováno v:
Mylonas, K J, Nair, M G, Prieto-Lafuente, L, Paape, D & Allen, J E 2009, ' Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing ', Journal of Immunology, vol. 182, no. 5, pp. 3084-3094 . https://doi.org/10.4049/jimmunol.0803463
The prime function of classically activated macrophages (activated by Th1-type signals, such as IFN-γ) is microbial destruction. Alternatively activated macrophages (activated by Th2 cytokines, such as IL-4 and IL-13) play important roles in allergy
Publikováno v:
Medical Microbiology and Immunology. 192:33-40
Mice exposed intraperitoneally to either adult or first larval stage (microfilaria) of the human nematode parasite Brugia malayi display polarized cytokine responses. We have used this model to investigate the impact of altered cytokine profiles on i
Autor:
Lauren M. Webb, Simon A. Babayan, Agnes Kurniawan, Judith E. Allen, Rick M. Maizels, Janice Murray, Yvonne Harcus, Dominik Rückerl, James P. Hewitson
Publikováno v:
Hewitson, J P, Rückerl, D, Harcus, Y, Murray, J, Webb, L M, Babayan, S A, Allen, J E, Kurniawan, A & Maizels, R M 2014, ' The Secreted Triose Phosphate Isomerase of Brugia malayi Is Required to Sustain Microfilaria Production In Vivo ', PLoS Pathogens, vol. 10, no. 2, e1003930 . https://doi.org/10.1371/journal.ppat.1003930
PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 2, p e1003930 (2014)
PLoS Pathogens; Vol 10
PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 2, p e1003930 (2014)
PLoS Pathogens; Vol 10
Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects. Microfilariae are produced by long-lived adult parasites, which also release a suite o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aae38670f75110620960f7fb5999edb
https://hdl.handle.net/20.500.11820/22568529-dac1-4ba6-ac91-bc9cedcbadfe
https://hdl.handle.net/20.500.11820/22568529-dac1-4ba6-ac91-bc9cedcbadfe
Publikováno v:
Infection and Immunity. 67:6329-6334
Ov20 is a structurally novel 20-kDa retinol binding protein secreted by Onchocerca volvulus . Immunological and biological investigation of this protein has been hampered by the inability to maintain O. volvulus in a laboratory setting. In an effort
Autor:
Judith E. Allen, Andrew S. MacDonald
Publikováno v:
Parasite Immunology. 20:241-247
Loss of T lymphocyte proliferation and the emergence of a host response that is dominated by a Th2-type profile are well-established features of human filarial infection. Down-regulation and modulation of host T cell responses during lymphatic filari
Autor:
Dominik Rückerl, Stephen J. Jenkins, Nouf N. Laqtom, Tara E. Sutherland, Judith E. Allen, Sheelagh Duncan, Amy H. Buck, Iain J. Gallagher
Publikováno v:
Ruckerl, D, Jenkins, S J, Laqtom, N N, Gallagher, I J, Sutherland, T E, Duncan, S, Buck, A H & Allen, J E 2012, ' Induction of IL-4R alpha-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo ', Blood, vol. 120, no. 11, pp. 2307-2316 . https://doi.org/10.1182/blood-2012-02-408252
Macrophage (MΦ) activation must be tightly controlled to preclude overzealous responses that cause self-damage. MicroRNAs promote classical MΦ activation by blocking antiinflammatory signals and transcription factors but also can prevent excessive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cf26899ab0e8c106b9f732fe3cd4a8
https://www.pure.ed.ac.uk/ws/files/8368800/BLOOD_2012_AllenJ.pdf
https://www.pure.ed.ac.uk/ws/files/8368800/BLOOD_2012_AllenJ.pdf