Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christopher L.-H. Huang"'
Autor:
Esther Bonet-Luz, MMath, PhD, Jane V. Lyle, BSc, Christopher L.-H. Huang, MA, BMBCh, DM, DSc, PhD, MD, ScD, Yanmin Zhang, MD, PhD, Manasi Nandi, BSc, PhD, Kamalan Jeevaratnam, DAHP, DVM, MMedSC, PhD, MRCVS, Philip J. Aston, BSc, PhD
Publikováno v:
Heart Rhythm O2, Vol 1, Iss 5, Pp 368-375 (2020)
Background: Life-threatening arrhythmias resulting from genetic mutations are often missed in current electrocardiogram (ECG) analysis. We combined a new method for ECG analysis that uses all the waveform data with machine learning to improve detecti
Externí odkaz:
https://doaj.org/article/fce511eb313c4fd4a215e909aeff36ca
Transcriptional profiles of genes related to electrophysiological function in Scn5a+/− murine hearts
Autor:
Michael Takla, Charlotte E. Edling, Kevin Zhang, Khalil Saadeh, Gary Tse, Samantha C. Salvage, Christopher L.‐H. Huang, Kamalan Jeevaratnam
Publikováno v:
Physiological Reports, Vol 9, Iss 19, Pp n/a-n/a (2021)
Abstract The Scn5a gene encodes the major pore‐forming Nav1.5 (α) subunit, of the voltage‐gated Na+ channel in cardiomyocytes. The key role of Nav1.5 in action potential initiation and propagation in both atria and ventricles predisposes organis
Externí odkaz:
https://doaj.org/article/edef003b381440f3af65dbd7393d25d6
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Externí odkaz:
https://doaj.org/article/77f6bccfa9ef4dc0b816fd9467f9db22
Autor:
Claire A. Martin, Urszula Siedlecka, Kristin Kemmerich, Jason Lawrence, James Cartledge, Laila Guzadhur, Nicola Brice, Andrew A. Grace, Christof Schwiening, Cesare M. Terracciano, Christopher L.-H. Huang
Publikováno v:
Open Biology, Vol 2, Iss 6 (2012)
Brugada syndrome (BrS) is associated with ventricular tachycardia originating particularly in the right ventricle (RV). We explore electrophysiological features predisposing to such arrhythmic tendency and their possible RV localization in a heterozy
Externí odkaz:
https://doaj.org/article/8392d10852b248d4aee21807befe5544
Transcriptional profiles of genes related to electrophysiological function in Scn5a+/- murine hearts
Autor:
Samantha C. Salvage, Kamalan Jeevaratnam, Charlotte E. Edling, Michael Takla, Gary Tse, Khalil Saadeh, Christopher L.-H. Huang, Kevin Zhang
Publikováno v:
Physiological Reports, Vol 9, Iss 19, Pp n/a-n/a (2021)
Funder: University of Surrey; Id: http://dx.doi.org/10.13039/501100003513
The Scn5a gene encodes the major pore‐forming Nav1.5 (α) subunit, of the voltage‐gated Na+ channel in cardiomyocytes. The key role of Nav1.5 in action potential initi
The Scn5a gene encodes the major pore‐forming Nav1.5 (α) subunit, of the voltage‐gated Na+ channel in cardiomyocytes. The key role of Nav1.5 in action potential initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1441935c644dcf3b2a59408139218e50
Autor:
Malcolm Finlay, Diogo Santos, Christopher L.-H. Huang, Vishal Vyas, Andrew A. Grace, Pier D. Lambiase, Peter Taggart, Andrew Tinker, J Bhar-Amato, Keat-Eng Ng, Michele Orini
Publikováno v:
Am J Physiol Cell Physiol
A murine line haploinsufficient in the cardiac sodium channel has been used to model human Brugada syndrome: a disease causing sudden cardiac death due to lethal ventricular arrhythmias. We explored the effects of cholinergic tone on electrophysiolog
Autor:
Esther Bonet-Luz, Philip J. Aston, Manasi Nandi, Christopher L.-H. Huang, Kamalan Jeevaratnam, Jane V Lyle, Yanmin Zhang
Publikováno v:
Heart Rhythm O2
Heart Rhythm O2, Vol 1, Iss 5, Pp 368-375 (2020)
Heart Rhythm O2, Vol 1, Iss 5, Pp 368-375 (2020)
Background Life-threatening arrhythmias resulting from genetic mutations are often missed in current electrocardiogram (ECG) analysis. We combined a new method for ECG analysis that uses all the waveform data with machine learning to improve detectio
Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome
Autor:
Pier D. Lambiase, Peter Taggart, J Bhar-Amato, Michele Orini, Andrew Tinker, Ron Ben Simon, Vishal Vyas, Andrew A. Grace, Diogo Santos, Malcolm Finlay, Sanjay Chaubey, Christopher L.-H. Huang
Publikováno v:
Circulation. Arrhythmia and electrophysiology. 11(9)
Background We explored the hypothesis that increased cholinergic tone exerts its proarrhythmic effects in Brugada syndrome (BrS) through increasing dispersion of transmural repolarization in patients with spontaneous and drug-induced BrS. Methods BrS
Publikováno v:
Acta Physiologica. 216:186-202
Normal cardiac excitation involves orderly conduction of electrical activation and recovery dependent upon surface membrane, voltage-gated, sodium (Na(+) ) channel α-subunits (Nav 1.5). We summarize experimental studies of physiological and clinical