Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Stefan Sleijfer"'
Autor:
Noortje Verschoor, Marcel Smid, Agnes Jager, Stefan Sleijfer, Saskia M. Wilting, John W. M. Martens
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background In breast cancer, the advent of anti-HER2 therapies has made HER2+ tumors a highly relevant subgroup. However, the exact characteristics which prohibit clinical response to anti-HER2 therapies and drive disease progression are not
Externí odkaz:
https://doaj.org/article/eb68c979d7994380af5986176e6bfa77
Autor:
Teoman Deger, Pauline A. J. Mendelaar, Jaco Kraan, Wendy J. C. Prager‐van der Smissen, Michelle van derVlugt‐Daane, Eric M. J. Bindels, Anieta M. Sieuwerts, Stefan Sleijfer, Saskia M. Wilting, Antoinette Hollestelle, John W. M. Martens
Publikováno v:
Molecular Oncology, Vol 16, Iss 16, Pp 2981-3000 (2022)
Intrapatient tumour heterogeneity is likely a major determinant of clinical outcome in cancer patients. To assess heterogeneity in a minimally invasive manner, methods to perform single circulating tumour cell (CTC) genomics at high resolution are ne
Externí odkaz:
https://doaj.org/article/670fed1d4b0e407da90d1dd04df95007
Autor:
Lindsay Angus, Marcel Smid, Saskia M. Wilting, Manouk K. Bos, Neeltje Steeghs, Inge R. H. M. Konings, Vivianne C. G. Tjan-Heijnen, Johanna M. G. H. van Riel, Agnes J. van de Wouw, CPCT Consortium, Edwin Cuppen, Martijn P. Lolkema, Agnes Jager, Stefan Sleijfer, John W. M. Martens
Publikováno v:
Cancers, Vol 15, Iss 17, p 4416 (2023)
Mutations in the estrogen receptor gene (ESR1), its transcriptional regulators, and the mitogen-activated protein kinase (MAPK) pathway are enriched in patients with endocrine-resistant metastatic breast cancer (MBC). Here, we integrated whole genome
Externí odkaz:
https://doaj.org/article/20cce45044e24c7984aa2046e7d671d0
Autor:
Silvia R. Vitale, Kirsten Ruigrok-Ritstier, A. Mieke Timmermans, Renée Foekens, Anita M. A. C. Trapman-Jansen, Corine M. Beaufort, Paolo Vigneri, Stefan Sleijfer, John W. M. Martens, Anieta M. Sieuwerts, Maurice P. H. M. Jansen
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-16 (2022)
Abstract Background In breast cancer (BC), recurrent fusion genes of estrogen receptor alpha (ESR1) and AKAP12, ARMT1 and CCDC170 have been reported. In these gene fusions the ligand binding domain of ESR1 has been replaced by the transactivation dom
Externí odkaz:
https://doaj.org/article/5619f8611366419781ebf77950eb8c5c
Autor:
Kiki C. Andree, Fikri Abali, Lisa Oomens, Fiona R. Passanha, Joska J. Broekmaat, Jaco Kraan, Pauline A.J. Mendelaar, Stefan Sleijfer, Leon W.M.M. Terstappen
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 477 (2019)
The availability of viable tumor cells could significantly improve the disease management of cancer patients. Here we developed and evaluated a method using self-seeding microwells to obtain single circulating tumor cells (CTC) and assess their poten
Externí odkaz:
https://doaj.org/article/6ed475e5ef174324bd2543c3a7c82bad
Autor:
Tanja Fehm, Luc Dirix, Stefan Sleijfer, Paola Gazzaniga, José A. García-Sáenz, Carlos Caldas, Rita Zamarchi, Karthik V. Giridhar, Lorenzo Gerratana, Massimo Cristofanilli, Luis Manso, Dimitrios Mavroudis, Kostandinos Sideras, Meredith M. Regan, Zefei Jiang, Michail Ignatiadis, Rafael Gisbert-Criado, William E. Barlow, François-Clément Bidard, Thomas W. P. Friedl, Klaus Pantel, Evi Lianidou, Daniele Generali, Jean-Yves Pierga, Sabine Riethdorf, Tracy C. Yab, Mark Jesus M. Magbanua, Jose Vidal-Martinez, Jeffrey B. Smerage, Brigitte Rack, Hope S. Rugo, Catherine Alix-Panabières, Lisa A. Carey, Minetta C. Liu, Volkmar Müller, William Jacot, Wolfgang Janni, Elisabetta Munzone, Justin Stebbing, Leon W.M.M. Terstappen, Daniel F. Hayes
Publikováno v:
Cancer Research. 81:GS4-08
Background: Several studies suggest clinical utility of serial circulating tumor cell (CTC) enumeration as a means of assessing response status in metastatic breast cancer (MBC). The aim of this study is to conduct a comprehensive pooled analysis com
Autor:
Maurice P.H.M. Jansen, Paolo Vigneri, Stefan Sleijfer, Corine M. Beaufort, Silvia R. Vitale, John Martens, Anieta M. Sieuwerts, Anita M. A. C. Trapman-Jansen, A. Mieke Timmermans, Kirsten Ruigrok-Ritstier, Renée Foekens
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-16 (2022)
BMC Cancer, 22(1):165. BioMed Central Ltd.
BMC Cancer, 22(1):165. BioMed Central Ltd.
Background In breast cancer (BC), recurrent fusion genes of estrogen receptor alpha (ESR1) and AKAP12, ARMT1 and CCDC170 have been reported. In these gene fusions the ligand binding domain of ESR1 has been replaced by the transactivation domain of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e83b5eb241980e2a29bd5c0b52757a0
http://hdl.handle.net/20.500.11769/524144
http://hdl.handle.net/20.500.11769/524144
Autor:
Wouter Dercksen, Dinja T. Kruger, Agnes Jager, Inge R. H. M. Konings, John W.M. Martens, Maurice P.H.M. Jansen, Jamal Oulad Hadj, Stefan Sleijfer, Epie Boven
Publikováno v:
Molecular Oncology, Vol 14, Iss 3, Pp 490-503 (2020)
Molecular Oncology, 14, 490-503. John Wiley & Sons Ltd.
Kruger, D T, Jansen, M P H M, Konings, I R H M, Dercksen, W M, Jager, A, Oulad Hadj, J, Sleijfer, S, Martens, J W M & Boven, E 2020, ' High ctDNA molecule numbers relate with poor outcome in advanced ER+, HER2-postmenopausal breast cancer patients treated with everolimus and exemestane ', Molecular oncology, vol. 14, no. 3, pp. 490-503 . https://doi.org/10.1002/1878-0261.12617
Molecular Oncology
Molecular oncology, 14(3), 490-503. Elsevier
Molecular Oncology, 14, 490-503. John Wiley & Sons Ltd.
Kruger, D T, Jansen, M P H M, Konings, I R H M, Dercksen, W M, Jager, A, Oulad Hadj, J, Sleijfer, S, Martens, J W M & Boven, E 2020, ' High ctDNA molecule numbers relate with poor outcome in advanced ER+, HER2-postmenopausal breast cancer patients treated with everolimus and exemestane ', Molecular oncology, vol. 14, no. 3, pp. 490-503 . https://doi.org/10.1002/1878-0261.12617
Molecular Oncology
Molecular oncology, 14(3), 490-503. Elsevier
We determined whether progression-free survival (PFS) in metastatic breast cancer (MBC) patients receiving everolimus plus exemestane (EVE/EXE) varies depending on circulating tumour DNA (ctDNA) characteristics. Baseline plasma cell-free DNA (cfDNA)
Autor:
Martin J. van den Bent, Irene van Heuvel, John W.M. Martens, Peter A. E. Sillevis Smitt, Lindsay Angus, Ellen Heitzer, Agnes Jager, Vanja de Weerd, Joost L.M. Jongen, Saskia M Wilting, Stefan Sleijfer, Teoman Deger, Eric M.J. Bindels, Johan M. Kros
Publikováno v:
Clinical Cancer Research, 27(10), 2798-2806. American Association for Cancer Research Inc.
Purpose: Detection of leptomeningeal metastasis is hampered by limited sensitivities of currently used techniques: MRI and cytology of cerebrospinal fluid (CSF). Detection of cell-free tumor DNA in CSF has been proposed as a tumor-specific candidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1ccdc4dd89fc871d0c77153a405de7
https://pure.eur.nl/en/publications/6a058c21-703c-4e80-bf69-96ced24c50fd
https://pure.eur.nl/en/publications/6a058c21-703c-4e80-bf69-96ced24c50fd
Autor:
Stefan Sleijfer, Paul Hamberg, Marcel Smid, Mieke Timmermans, Wendy Onstenk, John W.M. Martens, Jaco Kraan, Agnes Jager, Felix E. de Jongh, Ingeborg E. de Kruijff, Anieta M. Sieuwerts
Publikováno v:
International Journal of Cancer, 145(4), 1083-1089. Wiley-Liss Inc.
The androgen receptor (AR) has potential clinical relevance in metastatic breast cancer (mBC) since it might be a treatment target and has been associated with endocrine resistance. A minimal-invasive way to determine AR expression on metastatic tumo