Zobrazeno 1 - 10
of 178
pro vyhledávání: '"John W.M. Martens"'
Autor:
Anieta M. Sieuwerts, Shusma C. Doebar, Vanja de Weerd, Esther I. Verhoef, Corine M. Beauford, Marie C. Agahozo, John W.M. Martens, Carolien H.M. van Deurzen
Publikováno v:
Cancers, Vol 11, Iss 8, p 1062 (2019)
The underlying mechanism of the progression of ductal carcinoma in situ (DCIS), a non-obligate precursor of invasive breast cancer (IBC), has yet to be elucidated. In IBC, Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3B (APOBEC3B)
Externí odkaz:
https://doaj.org/article/14518df8bad24cc4989e6ccc4180c2d5
Autor:
Wouter Dercksen, Dinja T. Kruger, Agnes Jager, Inge R. H. M. Konings, John W.M. Martens, Maurice P.H.M. Jansen, Jamal Oulad Hadj, Stefan Sleijfer, Epie Boven
Publikováno v:
Molecular Oncology, Vol 14, Iss 3, Pp 490-503 (2020)
Molecular Oncology, 14, 490-503. John Wiley & Sons Ltd.
Kruger, D T, Jansen, M P H M, Konings, I R H M, Dercksen, W M, Jager, A, Oulad Hadj, J, Sleijfer, S, Martens, J W M & Boven, E 2020, ' High ctDNA molecule numbers relate with poor outcome in advanced ER+, HER2-postmenopausal breast cancer patients treated with everolimus and exemestane ', Molecular oncology, vol. 14, no. 3, pp. 490-503 . https://doi.org/10.1002/1878-0261.12617
Molecular Oncology
Molecular oncology, 14(3), 490-503. Elsevier
Molecular Oncology, 14, 490-503. John Wiley & Sons Ltd.
Kruger, D T, Jansen, M P H M, Konings, I R H M, Dercksen, W M, Jager, A, Oulad Hadj, J, Sleijfer, S, Martens, J W M & Boven, E 2020, ' High ctDNA molecule numbers relate with poor outcome in advanced ER+, HER2-postmenopausal breast cancer patients treated with everolimus and exemestane ', Molecular oncology, vol. 14, no. 3, pp. 490-503 . https://doi.org/10.1002/1878-0261.12617
Molecular Oncology
Molecular oncology, 14(3), 490-503. Elsevier
We determined whether progression-free survival (PFS) in metastatic breast cancer (MBC) patients receiving everolimus plus exemestane (EVE/EXE) varies depending on circulating tumour DNA (ctDNA) characteristics. Baseline plasma cell-free DNA (cfDNA)
Autor:
John M. S. Bartlett, Megan Hopkins, C. Poncet, Stefan Aebi, Peggy L. Porter, Elise van Leeuwen-Stok, Carolien H.M. van Deurzen, Quang M. Trinh, Kim Benstead, M Nowaczyk, Cecilia Nilsson, Lavinia P. Middleton, Lincoln Stein, Cheryl Crozier, Monika Sobol, Ingrid Hedenfalk, Sharon H. Giordano, Oliver Bogler, Jane Bayani, Joanna Vermeij, Lissandra Dal Lago, Christi J. van Asperen, Melissa Murray, Catherine M. Kelly, Kathryn J. Ruddy, Stéphanie Peeters, Tammy Piper, Carolien P. Schröder, Carrie Cunningham, Florentine Hilbers, Fatima Cardoso, Danielle Van den Weyngaert, Aime Lambert Uwimana, Aleksandra Peric, John W.M. Martens, Eric P. Winer, Isabel T. Rubio, Barbro Linderholm, Larissa A. Korde
Publikováno v:
Cancer Research. 80:P4-10
Introduction: Male breast cancer (BCa) is a rare disease accounting for less than 1% of all breast cancers (BC) and 1% of all cancers in males. The clinical management is largely extrapolated from female BCa. Few studies have examined the genomic lan
Autor:
Erik F. J. de Vries, Andor W. J. M. Glaudemans, Clasina M Venema, Ed Schuuring, Carolina P. Schröder, Geke A. P. Hospers, Jorianne Boers, Sjoerd G. Elias, Thomas C. Kwee, John W.M. Martens
Publikováno v:
European Journal of Cancer, 126, 11-20. ELSEVIER SCI LTD
European Journal of Cancer, 126, 11-20. Elsevier Ltd.
European Journal of Cancer, 126, 11-20. Elsevier Ltd.
BACKGROUND: Adding cyclin-dependent kinase (CDK) inhibitor to endocrine treatment improves outcome in œstrogen receptor (ER) positive metastatic breast cancer, but identifying the subset of patients who benefit is challenging. Response is potentiall
Autor:
John W.M. Martens, Paul J. van Diest, Carolien H.M. van Deurzen, Marijn A Vermeulen, Carolien P. Schröder
Publikováno v:
Journal of Clinical Pathology, 73(4), 204-208. BMJ Publishing Group
Journal of Clinical Pathology, 73(4), 204-208. BMJ PUBLISHING GROUP
Journal of Clinical Pathology, 73(4), 204-208. BMJ PUBLISHING GROUP
AimsThe aim of this study was to determine the role of hypoxia in male breast carcinogenesis by evaluating the expression of the hypoxia-related proteins, hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase IX (CAIX) and glucose transporter-1
Autor:
Arne Van Hoeck, Ewart W. Kuijk, Bastiaan van der Roest, Sharon Christensen, Edwin Cuppen, John W.M. Martens, Peter Priestley, Sander Boymans, Marie-Laure Yaspo, Roel Janssen, Nicolle Besselink
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications, 10(1). Nature Publishing Group
Nature Communications, 10:4571. Nature Publishing Group
Nature Communications
Nature Communications, 10(1). Nature Publishing Group
Nature Communications, 10:4571. Nature Publishing Group
5-Fluorouracil (5-FU) is a chemotherapeutic drug commonly used for the treatment of solid cancers. It is proposed that 5-FU interferes with nucleotide synthesis and incorporates into DNA, which may have a mutational impact on both surviving tumor and
Autor:
Nicolle Besselink, Pier Selenica, Pjotr Prins, Britta Weigelt, Bert van der Vegt, Cathy B. Moelans, Peter Bult, Carmen C. van der Pol, Marco J. Koudijs, Marlous Hoogstraat, Robert Kornegoor, Jorge S. Reis-Filho, Paul J. van Diest, Natalie D. ter Hoeve, Isaac J. Nijman, Elsken van der Wall, Edwin Cuppen, Emile E. Voest, John W.M. Martens, Petra van der Groep, Wendy W.J. de Leng, Joep de Ligt, Miangela M. Lacle, Ellis Barbé, Vincent T.H.B.M. Smit
Publikováno v:
Endocr Relat Cancer
Endocrine-Related Cancer, 26(10), 779-794. Society for Endocrinology
Endocrine-Related Cancer, 26(10), 779. Society for Endocrinology
Endocrine-Related Cancer, 26(10), 779-794. Bioscientifica Ltd
Endocrine-Related cancer, 26(10), 779-794. BIOSCIENTIFICA LTD
Moelans, C B, de Ligt, J, van der Groep, P, Prins, P, Besselink, N J M, Hoogstraat, M, ter Hoeve, N D, Lacle, M M, Kornegoor, R, van der Pol, C C, de Leng, W W J, Barbé, E, van der Vegt, B, Martens, J, Bult, P, Smit, V T H B M, Koudijs, M J, Nijman, I J, Voest, E E, Selenica, P, Weigelt, B, Reis-Filho, J S, van der Wall, E, Cuppen, E & van Diest, P J 2019, ' The molecular genetic make-up of male breast cancer ', Endocrine-Related Cancer, vol. 26, no. 10, pp. 779-794 . https://doi.org/10.1530/ERC-19-0278
Endocrine-Related Cancer, 26(10), 779-794. Society for Endocrinology
Endocrine-Related Cancer, 26(10), 779. Society for Endocrinology
Endocrine-Related Cancer, 26(10), 779-794. Bioscientifica Ltd
Endocrine-Related cancer, 26(10), 779-794. BIOSCIENTIFICA LTD
Moelans, C B, de Ligt, J, van der Groep, P, Prins, P, Besselink, N J M, Hoogstraat, M, ter Hoeve, N D, Lacle, M M, Kornegoor, R, van der Pol, C C, de Leng, W W J, Barbé, E, van der Vegt, B, Martens, J, Bult, P, Smit, V T H B M, Koudijs, M J, Nijman, I J, Voest, E E, Selenica, P, Weigelt, B, Reis-Filho, J S, van der Wall, E, Cuppen, E & van Diest, P J 2019, ' The molecular genetic make-up of male breast cancer ', Endocrine-Related Cancer, vol. 26, no. 10, pp. 779-794 . https://doi.org/10.1530/ERC-19-0278
Male breast cancer (MBC) is extremely rare and accounts for less than 1% of all breast malignancies. Therefore, clinical management of MBC is currently guided by research on the disease in females. In this study, DNA obtained from 45 formalin-fixed p
Autor:
Bob van de Water, Ronan P. McLaughlin, Yinghui Zhang, John W.M. Martens, Marcel Smid, John A. Foekens, Vera E. van der Noord
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports, 9(1), 13308
Scientific Reports, 9:13308. Nature Publishing Group
Scientific Reports
Scientific Reports, 9(1), 13308
Scientific Reports, 9:13308. Nature Publishing Group
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor clinical prognosis and limited targeted treatment strategies. Kinase inhibitor screening of a panel of 20 TNBC cell lines uncovered three critical TNBC subgroups
Autor:
Chayenne J. Heijerman, Marie Colombe Agahozo, Mieke Timmermans, Dora Hammerl, Carolien H.M. van Deurzen, Ronald van Marion, Marcel Smid, Reno Debets, Pieter J. Westenend, Thierry P P van den Bosch, John W.M. Martens
Publikováno v:
Biology
Volume 10
Issue 8
Biology, Vol 10, Iss 768, p 768 (2021)
Biology, 10(8):768. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 10
Issue 8
Biology, Vol 10, Iss 768, p 768 (2021)
Biology, 10(8):768. Multidisciplinary Digital Publishing Institute (MDPI)
Simple Summary Tumor-infiltrating lymphocytes (TILs) are likely to play a role in the biological behavior of HER2+ ductal carcinoma in situ (DCIS). To prevent invasiveness, the potential of targeted immune-modulating treatment of HER2+ DCIS has been
Autor:
Martin J. van den Bent, Irene van Heuvel, John W.M. Martens, Peter A. E. Sillevis Smitt, Lindsay Angus, Ellen Heitzer, Agnes Jager, Vanja de Weerd, Joost L.M. Jongen, Saskia M Wilting, Stefan Sleijfer, Teoman Deger, Eric M.J. Bindels, Johan M. Kros
Publikováno v:
Clinical Cancer Research, 27(10), 2798-2806. American Association for Cancer Research Inc.
Purpose: Detection of leptomeningeal metastasis is hampered by limited sensitivities of currently used techniques: MRI and cytology of cerebrospinal fluid (CSF). Detection of cell-free tumor DNA in CSF has been proposed as a tumor-specific candidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1ccdc4dd89fc871d0c77153a405de7
https://pure.eur.nl/en/publications/6a058c21-703c-4e80-bf69-96ced24c50fd
https://pure.eur.nl/en/publications/6a058c21-703c-4e80-bf69-96ced24c50fd