Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ebbe Boedtkjer"'
Autor:
Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-27 (2023)
Abstract Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated consequences of carbonic anhydrases for cancer and stromal
Externí odkaz:
https://doaj.org/article/43eb9c61abb047289a64eb505c8ecf73
Autor:
Anne Sofie Froelunde, Marit Ohlenbusch, Kristoffer B. Hansen, Nicolai Jessen, Sukhan Kim, Ebbe Boedtkjer
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-12 (2018)
Abstract Background Perfusion of breast cancer tissue limits oxygen availability and metabolism but angiogenesis inhibitors have hitherto been unsuccessful for breast cancer therapy. In order to identify abnormalities and possible therapeutic targets
Externí odkaz:
https://doaj.org/article/d2b1026fff6c4f5fbe10b90516142202
Autor:
Mikkel B. Henningsen, Kezia McWhan, Vibeke S. Dam, Marco Mele, Katrine R. Hauerslev, Ninna C. S. Voss, Parag D. Dabir, Eva Balling, Helene L. Pedersen, Pernille Vahl, Tonje Johansen, Trine Tramm, Peer M. Christiansen, Ebbe Boedtkjer
Publikováno v:
Henningsen, M B, McWhan, K, Dam, V S, Mele, M, Hauerslev, K R, Voss, N C S, Dabir, P D, Balling, E, Pedersen, H L, Vahl, P, Johansen, T, Tramm, T, Christiansen, P M & Boedtkjer, E 2022, ' Amplified Ca 2+ dynamics and accelerated cell proliferation in breast cancer tissue during purinergic stimulation ', International Journal of Cancer, vol. 151, no. 7, pp. 1150-1165 . https://doi.org/10.1002/ijc.34147
Intracellular Ca 2+ dynamics shape malignant behaviors of cancer cells. Whereas previous studies focused on cultured cancer cells, we here used breast organoids and colonic crypts freshly isolated from human and murine surgical biopsies. We performed
Autor:
Ebbe Boedtkjer
Publikováno v:
Boedtkjer, E 2019, ' Na +,HCO 3 – cotransporter NBCn1 accelerates breast carcinogenesis ', Cancer and Metastasis Reviews, vol. 38, no. 1-2, pp. 165-178 . https://doi.org/10.1007/s10555-019-09784-7
Cell metabolism increases during carcinogenesis. Yet, intracellular pH in solid cancer tissue is typically maintained equal to or above that of normal tissue. This is achieved through accelerated cellular acid extrusion that compensates for the enhan
Autor:
Ebbe Boedtkjer, Ninna C. S. Voss, Bent Honoré, Pernille Vahl, Thomas Dreyer, Mikkel B. Henningsen
Publikováno v:
Cancers, Vol 12, Iss 891, p 891 (2020)
Voss, N C S, Dreyer, T K, Henningsen, M B, Vahl, P, Honoré, B & Boedtkjer, E 2020, ' Targeting the acidic tumor microenvironment: Unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue ', Cancers, vol. 12, no. 4, 891 . https://doi.org/10.3390/cancers12040891
Cancers
Volume 12
Issue 4
Voss, N C S, Dreyer, T K, Henningsen, M B, Vahl, P, Honoré, B & Boedtkjer, E 2020, ' Targeting the acidic tumor microenvironment: Unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue ', Cancers, vol. 12, no. 4, 891 . https://doi.org/10.3390/cancers12040891
Cancers
Volume 12
Issue 4
The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based breast cancer induction, we supply either regular or NaHCO3-containing drinkin
Autor:
Nicolai Jessen, Ebbe Boedtkjer, Stine F. Pedersen, Trine V Axelsen, Soojung Lee, Pernille Vahl
Publikováno v:
Lee, S, Axelsen, T V, Jessen, N, Pedersen, S F, Vahl, P & Boedtkjer, E 2018, ' Na +,HCO 3 –-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice ', Oncogene, vol. 37, no. 41, pp. 5569-5584 . https://doi.org/10.1038/s41388-018-0353-6
Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7654b11d4dea51650c8a3abd257d60ad
https://pure.au.dk/portal/da/publications/na-hco3cotransporter-nbcn1-slc4a7-accelerates-erbb2induced-breast-cancer-development-and-tumor-growth-in-mice(b1077be5-30cd-4d20-acfa-cbf2016586c9).html
https://pure.au.dk/portal/da/publications/na-hco3cotransporter-nbcn1-slc4a7-accelerates-erbb2induced-breast-cancer-development-and-tumor-growth-in-mice(b1077be5-30cd-4d20-acfa-cbf2016586c9).html
Publikováno v:
Aarhus University
MedChemComm 6(12), 2163-2169 (2015). doi:10.1039/C5MD00367A
Steinkamp, A-D, Seling, N, Lee, S, Boedtkjer, E & Bolm, C 2015, ' Synthesis of N-cyano-substituted sulfilimine and sulfoximine derivatives of S0859 and their biological evaluation as sodium bicarbonate co-transport inhibitors ', MedChemComm, vol. 6, pp. 2163-2169 .
MedChemComm 6(12), 2163-2169 (2015). doi:10.1039/C5MD00367A
Steinkamp, A-D, Seling, N, Lee, S, Boedtkjer, E & Bolm, C 2015, ' Synthesis of N-cyano-substituted sulfilimine and sulfoximine derivatives of S0859 and their biological evaluation as sodium bicarbonate co-transport inhibitors ', MedChemComm, vol. 6, pp. 2163-2169 .
MedChemComm 6(12), 2163-2169(2015). doi:10.1039/C5MD00367A
Published by RSC Publ., Cambridge
Published by RSC Publ., Cambridge
Autor:
Ebbe Boedtkjer, Peer Christiansen, José M.A. Moreira, Stine F. Pedersen, Marco Mele, Pernille Vahl, Vibeke Jensen, Christian Aalkjaer, Vera Timmermans Wielenga
Publikováno v:
International Journal of Cancer. 132:1288-1299
Genome-wide association studies recently linked the locus for Na(+),HCO(3)(-)-cotransporter NBCn1 (SLC4A7) to breast cancer susceptibility, yet functional insights have been lacking. To determine whether NBCn1, by transporting HCO(3)(-) into cells, m
Publikováno v:
Lee, S, Mele, M, Vahl, P, Christiansen, P M, Jensen, V E D & Bødtkjer, E 2015, ' Na+,HCO3--cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane ', Pflügers Archiv-European Journal of Physiology, vol. 467, no. 2, pp. 367-377 . https://doi.org/10.1007/s00424-014-1524-0
Metabolic and biochemical changes during breast carcinogenesis enhance cellular acid production. Extrusion of the acid load from the cancer cells raises intracellular pH, while it decreases extracellular pH creating an inverted pH gradient across the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a96d3e9e9b8e903ecacc3f31f6d4cf2
https://pure.au.dk/portal/da/publications/nahco3cotransport-is-functionally-upregulated-during-human-breast-carcinogenesis-and-required-for-the-inverted-ph-gradient-across-the-plasma-membrane(a59484eb-b229-4992-8a50-3357b9f406f2).html
https://pure.au.dk/portal/da/publications/nahco3cotransport-is-functionally-upregulated-during-human-breast-carcinogenesis-and-required-for-the-inverted-ph-gradient-across-the-plasma-membrane(a59484eb-b229-4992-8a50-3357b9f406f2).html
Autor:
Marco Mele, Ebbe Boedtkjer, Stine F. Pedersen, José M.A. Moreira, Vera Timmermans Wielenga, Christian Aalkjaer, Vibeke Jensen, Pernille Vahl, Soojung Lee, Peer Christiansen
Publikováno v:
Cancer Research. 73:P3-03
High metabolism and insufficient blood supply are characteristics of cancer tissue, which in combination with biochemical changes favor glycolytic metabolism and result in prominent intracellular acid production. Although extracellular pH at the core