Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Michael T. Williams"'
Publikováno v:
Clin Oncol (R Coll Radiol)
Ionising radiation causes secondary tumours and/or enduring cognitive deficits, especially in children. Proton radiotherapy reduces exposure of the developing brain in children but may still cause some lasting effects. Recent observations show that u
Autor:
Michael T. Williams, Chiho Sugimoto, Samantha L. Regan, Emily M. Pitzer, Adam L. Fritz, Mathieu Sertorio, Anthony E. Mascia, Ralph E. Vatner, John P. Perentesis, Charles V. Vorhees
Publikováno v:
PloS one. 17(9)
Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive decline compared with conventional radiation dose rates (~1 Gy/s), but further preclinical dat
Publikováno v:
Neurosci Biobehav Rev
Latrophilin-3 (LPHN3), a G-protein-coupled receptor belonging to the adhesion subfamily, is a regulator of synaptic function and maintenance in brain regions that mediate locomotor activity, attention, and memory for location and path. Variants of LP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96c0e768fbc9ed3db5a1de7c4d037aa
https://europepmc.org/articles/PMC8292202/
https://europepmc.org/articles/PMC8292202/
Autor:
Michael T. Williams, Ann M. Hemmerle, Kim B. Seroogy, Tara L Kyser, Rebecca A. Bailey, Charles V. Vorhees, Arnold Gutierrez, Jillian R. Hufgard
Publikováno v:
Neurotoxicity Research. 35:606-620
Manganese (Mn) is an essential nutrient especially during development, but Mn overexposure (MnOE) produces long-term cognitive deficits. Evidence of long-term changes in dopamine in the neostriatum was found in rats from developmental MnOE previously
Publikováno v:
Toxicol Sci
Deltamethrin (DLM) is a commonly used pesticide that helps to control crop destruction, disease, and nuisance insects. In rodents DLM can produce choreoathetosis, salivation, and decreased acoustic startle responses (ASR). Herein, adult Sprague Dawle
Publikováno v:
Toxicology and Applied Pharmacology. 354:176-190
High throughput screens for developmental neurotoxicity (DN) will facilitate evaluation of chemicals and can be used to prioritize those designated for follow-up. DN is evaluated under different guidelines. Those for drugs generally include peri- and
Publikováno v:
Neurotoxicol Teratol
Deltamethrin (DLM) is a Type II pyrethroid pesticide widely used in agriculture, homes, public spaces, and medicine. Epidemiological studies report that increased pyrethroid exposure during development is associated with neurobehavioral disorders. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef0a3ae5591c02d44f64e84da730b52
https://europepmc.org/articles/PMC8440325/
https://europepmc.org/articles/PMC8440325/
Publikováno v:
Toxicological Sciences. 165:361-371
Permethrin is a type I (noncyano) pyrethroid that induces tremors at high concentrations and increases acoustic startle responses (ASRs) in adult rodents, however its effects in young rats have been investigated to a limited extent. ASR and tremor we
Publikováno v:
Neurotoxicology and Teratology. 57:1-19
Advantageous maneuvering through the environment to find food and avoid or escape danger is central to survival of most animal species. The ability to do so depends on learning and remembering different locations, especially home-base. This capacity
Autor:
Chiho Sugimoto, Leonid M. Yermakov, Michael T. Williams, Domenica E. Drouet, Keiichiro Susuki, Ryan B. Griggs, Charles V. Vorhees
Publikováno v:
Behav Brain Res
Impaired executive function is a major peril for patients with type 2 diabetes, reducing quality of life and ability for diabetes management. Despite the significance of this impairment, few animal models of type 2 diabetes examine domains of executi