Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Harris, TB"'
Autor:
Surendran P; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Feofanova EV; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Lahrouchi N; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Amsterdam UMC, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences Amsterdam, Amsterdam, the Netherlands., Ntalla I; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Karthikeyan S; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Cook J; Department of Biostatistics, University of Liverpool, Liverpool, UK., Chen L; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Mifsud B; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar., Yao C; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Kraja AT; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Cartwright JH; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hellwege JN; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA., Giri A; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.; Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA., Tragante V; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; deCODE genetics/Amgen, Inc, Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen, Inc, Reykjavik, Iceland., Liu DJ; Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA., Prins BP; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Stewart ID; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Cabrera CP; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Eales JM; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Akbarov A; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Auer PL; Joseph J Zilber School of Public Health, University of Wisconsin, Milwaukee, WI, USA., Bielak LF; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Braithwaite VS; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; MRC Nutrition and Bone Health Group, University of Cambridge, Cambridge, UK.; MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Daw EW; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Drenos F; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK., Nielsen SF; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Fauman EB; Internal Medicine Research Unit, Pfizer, Cambridge, MA, USA., Fava C; Department of Medicine, University of Verona, Verona, Italy.; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Ferreira T; The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Foley CN; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Franceschini N; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Gao H; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK., Giannakopoulou O; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Centre for Genomic Health, Queen Mary University of London, London, UK.; Division of Psychiatry, University College of London, London, UK., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gudbjartsson DF; deCODE genetics/Amgen, Inc, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Guo X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Havulinna AS; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Helgadottir A; deCODE genetics/Amgen, Inc, Reykjavik, Iceland., Huffman JE; MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK., Hwang SJ; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.; Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Centre for Genomic Health, Life Sciences, Queen Mary University of London, London, UK., Kontto J; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Larson MG; Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.; Biostatistics Department, Boston University School of Public Health, Boston, MA, USA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Lindström J; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Lotta LA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Lu Y; The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Malerba G; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Masca NGD; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK., Mei H; Department of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Mosen-Ansorena D; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany., Paré G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Paul DS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Perola M; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Clinical and Molecular Metabolism Research Program (CAMM), Faculty of Medicine, University of Helsinki, Helsinki, Finland., Poveda A; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Richard M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Richardson TG; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Sepúlveda N; Department of Infection Biology, Faculty of Tropical and Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK.; Centre of Statistics and Applications of University of Lisbon, Lisbon, Portugal., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Saw Swee Hock School of Public Health, National University of, Singapore, Singapore., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Staley JR; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Stanáková A; University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Sulem P; deCODE genetics/Amgen, Inc, Reykjavik, Iceland., Thériault S; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, Quebec, Canada., Thorsteinsdottir U; deCODE genetics/Amgen, Inc, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Trompet S; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden., Velez Edwards DR; Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Tennessee Valley Health Systems VA, Nashville, TN, USA., Veronesi G; Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Willems SM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Yao J; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Young R; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Yu B; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Zhang W; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK., Zhao JH; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Zhao W; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Evangelou E; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Aeschbacher S; Division of Cardiology, University Hospital, Basel, Switzerland., Asllanaj E; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Department of Epidemiology, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands., Blankenberg S; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.; University Medical Center Hamburg Eppendorf, Hamburg, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK., Burgess S; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Christensen C; Medical Department, Lillebaelt Hospital, Vejle, Denmark., Connell J; University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK., Dörr M; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.; Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK., Gaziano JM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grove ML; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Hallmans G; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Have CT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Heiss G; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Jørgensen ME; Steno Diabetes Center, Copenhagen, Gentofte, Denmark., Jousilahti P; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Kajantie E; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland., Kamat M; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Vaasa, Finland., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Kovesdy CP; Nephrology Section, Memphis VA Medical Center, Memphis, TN, USA., Kuulasmaa K; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Laatikainen T; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Lannfelt L; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Lee IT; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, , Chung Shan Medical University, Taichung, Taiwan.; College of Science, Tunghai University, Taichung, Taiwan., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Social Work, Tunghai University, Taichung, Taiwan., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Martin LW; George Washington University School of Medicine and Health Sciences, Washington DC, USA., Moitry M; Department of Public health, Strasbourg University Hospital, University of Strasbourg, Strasbourg, France., Nadkarni G; The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Neville MJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Palmer CNA; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK., Papanicolaou GJ; Epidemiology Branch, NHLBI, Bethesda, MD, USA., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Peters J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK., Poulter N; International Centre for Circulatory Health, Imperial College London, London, UK., Rasheed A; Centre for Non-Communicable Diseases, Karachi, Pakistan., Rasmussen KL; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Rayner NW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Mägi R; Institute of Genomics, University of Tartu, Tartu, Estonia., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Rettig R; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany., Rossouw J; Division of Cardiovascular Sciences, NHLBI, Bethesda, MD, USA., Schreiner PJ; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA., Sever PS; National Heart and Lung Institute, Imperial College London, London, UK., Sigurdsson EL; Department of Family Medicine, University of Iceland, Reykjavik, Iceland.; Development Centre for Primary Health Care in Iceland, Reykjavik, Iceland., Skaaby T; Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA., Sundstrom J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Thorgeirsson G; deCODE genetics/Amgen, Inc, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Internal Medicine, Division of Cardiology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia.; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Trabetti E; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Tsao PS; VA Palo Alto Health Care System, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Tuomi T; Folkhälsan Research Centre, Helsinki, Finland.; Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden Institute for Molecular Medicine Helsinki (FIMM), Helsinki University, Helsinki, Finland., Turner ST; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA., Tzoulaki I; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Vaartjes I; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, University of Utrecht, Utrecht, the Netherlands.; Center for Circulatory Health, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands., Vergnaud AC; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Wilson PWF; Atlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA., Witte DR; Department of Public Health, Aarhus University, Aarhus, Denmark.; Danish Diabetes Academy, Odense, Denmark.; Steno Diabetes Center Aarhus, Aarhus, Denmark., Yonova-Doing E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Zhang H; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA., Aliya N; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Almgren P; Department of Medicine, Lund University, Malmö, Sweden., Amouyel P; Univ Lille, U1167 - RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.; INSERM, U1167, Lille, France.; CHU Lille, U1167, Lille, France.; Institut Pasteur de Lille, U1167, Lille, France., Asselbergs FW; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.; Health Data Research UK, Institute of Health Informatics, University College London, London, UK., Barnes MR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Blakemore AI; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.; Section of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, University of Utrecht, Utrecht, the Netherlands.; Center for Circulatory Health, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Buring JE; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chambers JC; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Imperial College Healthcare NHS Trust, London, UK., Chen YI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Chowdhury R; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Non-communicable Disease Research (CNCR), Dhaka, Bangladesh., Conen D; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Cardiovascular Research Institute Basel, Basel, Switzerland., Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Davey Smith G; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Boer RA; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK.; Centre for Genomic Health, Life Sciences, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Di Angelantonio E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.; National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK., Elliott P; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.; Health Data Research UK-London at Imperial College London, London, UK.; UKDRI, Dementia Research Institute at Imperial College London, London, UK.; British Heart Foundation (BHF) Centre of Research Excellence, Imperial College London, London, UK., Felix SB; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Ferrières J; Department of Cardiology and Department of Epidemiology, INSERM UMR 1027, Toulouse University Hospital, Toulouse, France., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Fornage M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.; Oxford Center for Diabetes, Endocrinology & Metabolism, Radcliff Department of Medicine, University of Oxford, Oxford, UK., Franks S; Institute of Reproductive & Developmental Biology, Imperial College London, London, UK., Frossard P; Centre for Non-Communicable Diseases, Karachi, Pakistan., Gambaro G; Division of Nephrology, Department of Medicine, University of Verona, Verona, Italy., Gaunt TR; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Medicine Helsinki (FIMM), Helsinki University, Helsinki, Finland., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute of Aging, Bethesda, MD, USA., Hayward C; MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK., Hennig BJ; MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia.; Wellcome Trust, London, UK., Herzig KH; Institute of Biomedicine, Medical Research Center (MRC), University of Oulu, and University Hospital Oulu, Oulu, Finland.; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA., Tuomilehto J; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; National Institute of Public Health, Madrid, Spain., Järvelin MR; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.; Unit of Primary Care, Oulu University Hospital, Kajaanintie, Oulu, Finland.; Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Kardia SLR; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Kee F; Centre for Public Health, Queens University Belfast, Belfast, UK., Kooner JS; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK.; National Heart and Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK., Kooperberg C; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute of Aging, Bethesda, MD, USA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Loos RJF; The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Majumder AAS; National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.; Genentech, South San Francisco, San Francisco, CA, USA., Melander O; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Murray AD; The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK., Nordestgaard BG; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Orho-Melander M; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Packard CJ; University of Glasgow, Glasgow, UK., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Palmas W; Department of Medicine, Columbia University Medical Center, New York, NY, USA., Polasek O; Department of Public Health, University of Split School of Medicine, Split, Croatia., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK., Prentice AM; MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia.; MRC International Nutrition Group at London School of Hygiene and Tropical Medicine, Keppel St, London, UK., Province MA; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Relton CL; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Rice K; Department of Biostatistics, University of Washington, Seattle, WA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Rolandsson O; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Rotter JI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rudan I; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Scotland, UK., Salomaa V; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK., Sattar N; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK., Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan.; Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan., Smith BH; Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Soranzo N; National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh, UK., Sebert S; Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Taylor KD; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland., Timpson NJ; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Tobin MD; National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK.; Department of Health Sciences, University of Leicester, Leicester, UK., van der Harst P; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands., van der Meer P; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands., Ramachandran VS; Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.; Boston University Schools of Medicine and Public Health, Boston, MA, USA., Verweij N; University Medical Center Groningen, Groningen, the Netherlands., Virtamo J; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Zeggini E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany., Charchar FJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; Health Innovation and Transformation Center, Federation University Australia, Ballarat, Victoria, Australia.; Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Tomaszewski M; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.; Division of Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.; National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.; National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Edwards TL; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA., Holm H; deCODE genetics/Amgen, Inc, Reykjavik, Iceland., Hung AM; VA Tennessee Valley Healthcare System, Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA., Lindgren CM; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Liu C; Boston University School of Public Health, Boston, MA, USA., Manning AK; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA., Morris AP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., O'Donnell CJ; VA Boston Healthcare, Section of Cardiology and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Saleheen D; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Stefansson K; deCODE genetics/Amgen, Inc, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Levy D; Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.; Population Sciences, Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD, USA., Newton-Cheh C; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk., Howson JMM; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. JMMHowson@gmail.com.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK. JMMHowson@gmail.com.; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK. JMMHowson@gmail.com.; Novo Nordisk Research Centre Oxford, Novo Nordisk Ltd, Oxford, UK. JMMHowson@gmail.com.
Publikováno v:
Nature genetics [Nat Genet] 2020 Dec; Vol. 52 (12), pp. 1314-1332. Date of Electronic Publication: 2020 Nov 23.
Autor:
Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK., Mosen-Ansorena D; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Mifsud B; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Pazoki R; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Gao H; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Ntritsos G; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Dimou N; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Cabrera CP; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK., Karaman I; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Ng FL; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Evangelou M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Mathematics, Imperial College London, London, UK., Witkowska K; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Tzanis E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hellwege JN; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA., Giri A; Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center; Tennessee Valley Health Systems VA, Nashville, TN, USA., Velez Edwards DR; Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center; Tennessee Valley Health Systems VA, Nashville, TN, USA., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital; Department of Medicine, Harvard Medical School, Boston, MA, USA., Gaziano JM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital; Department of Medicine, Harvard Medical School, Boston, MA, USA., Wilson PWF; Atlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA., Tsao PS; VA Palo Alto Health Care System, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Kovesdy CP; Nephrology Section, Memphis VA Medical Center and University of Tennessee Health Science Center, Memphis, TN, USA., Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Almgren P; Department Clinical Sciences, Malmö, Lund University, Malmö, Sweden., Boutin T; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK., Debette S; Department of Neurology, Bordeaux University Hospital, Bordeaux, France.; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, CHU Bordeaux, Bordeaux, France., Ding J; Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Holliday EG; Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Lin WY; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Oldmeadow C; Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia., Prins BP; Wellcome Trust Sanger Institute, Hinxton, UK., Qian Y; Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA., Sargurupremraj M; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, CHU Bordeaux, Bordeaux, France., Shah N; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.; Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan., Surendran P; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Thériault S; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada., Verweij N; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands., Willems SM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Amouyel P; University of Lille, Inserm, Centre Hosp. Univ. Lille, Institut Pasteur de Lille, UMR1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Epidemiology and Public Health Department, Lille, France., Connell J; University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Doney ASF; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK., Farrall M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Menni C; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK., Morris AD; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Noordam R; Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Paré G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Poulter NR; Imperial Clinical Trials Unit, London, UK., Shields DC; School of Medicine, University College Dublin, Dublin, Ireland., Stanton A; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Thom S; International Centre for Circulatory Health, Imperial College London, London, UK., Abecasis G; Center for Statistical Genetics, Department of Biostatistics, SPH II, Washington Heights, Ann Arbor, MI, USA., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Arking DE; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ayers KL; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.; Sema4, a Mount Sinai venture, Stamford, CT, USA., Barbieri CM; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy., Batini C; Department of Health Sciences, University of Leicester, Leicester, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Blake T; Department of Health Sciences, University of Leicester, Leicester, UK., Bochud M; Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Boerwinkle E; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston and Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Brumat M; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy., Campbell A; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Campbell H; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Department of Cardiology, Ealing Hospital, Middlesex, UK.; Imperial College Healthcare NHS Trust, London, UK., Chauhan G; Centre for Brain Research, Indian Institute of Science, Bangalore, India., Ciullo M; Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Napoli, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Cocca M; Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy., Collins F; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA., Cordell HJ; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK., Davies G; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., de Borst MH; Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., de Geus EJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Deelen J; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Del Greco M F; Institute for Biomedicine, Eurac Research, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany., Demirkale CY; Mathematical and Statistical Computing Laboratory, Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Ehret GB; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Cardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland., Elosua R; CIBERCV & Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain.; Faculty of Medicine, Universitat de Vic-Central de Catalunya, Vic, Spain., Enroth S; Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden., Erzurumluoglu AM; Department of Health Sciences, University of Leicester, Leicester, UK., Ferreira T; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK., Frånberg M; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Centre for Molecular Medicine, L8:03, Karolinska Universitetsjukhuset, Solna, Sweden.; Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden., Franco OH; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Gandin I; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy., Gasparini P; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Girotto G; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy., Goel A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Gow AJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh, UK., Gudnason V; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Icelandic Heart Association, Kopavogur, Iceland., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Gyllensten U; Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Centre for Molecular Medicine, L8:03, Karolinska Universitetsjukhuset, Solna, Sweden., Harris TB; Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA., Harris SE; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Havulinna AS; Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Hicks AA; Institute for Biomedicine, Eurac Research, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Hofman A; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands., Huffman JE; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; The Population Science Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Hwang SJ; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; The Population Science Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., James A; Department of Pulmonary Physiology and Sleep, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia, Australia.; School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia., Jansen R; Department of Psychiatry, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, the Netherlands., Jarvelin MR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Center For Life-course Health Research, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Oulu, Finland., Joehanes R; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA., Johansson Å; Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden., Johnson AD; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Joshi PK; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Jousilahti P; Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Jula A; Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Kathiresan S; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Keavney BD; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; Division of Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Khaw KT; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK., Knekt P; Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland., Knight J; Data Science Institute and Lancaster Medical School, Lancaster, UK., Kolcic I; Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia., Kooner JS; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK.; Imperial College Healthcare NHS Trust, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Koskinen S; Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland., Kristiansson K; Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland., Kutalik Z; Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Laan M; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Larson M; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Launer LJ; Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Liewald DCM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Lin L; Cardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden., Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Liu Y; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lopez LM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.; University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD, Belfield, Dublin, Ireland., Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Mamasoula C; Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK., Marrugat J; CIBERCV & Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain., Marten J; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK., Milaneschi Y; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical Center/GGZ inGeest, Amsterdam, the Netherlands., Morgan A; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Morrison AC; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Munson PJ; Mathematical and Statistical Computing Laboratory, Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA., Nalls MA; Data Tecnica International, Glen Echo, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Nandakumar P; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Niiranen T; Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.; Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Nutile T; Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Napoli, Italy., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Oostra BA; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., O'Reilly PF; SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Org E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Padmanabhan S; Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Palmas W; Department of Medicine, Columbia University Medical Center, New York, NY, USA., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pattie A; Department of Psychology, University of Edinburgh, Edinburgh, UK., Penninx BWJH; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical Center/GGZ inGeest, Amsterdam, the Netherlands., Perola M; Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; University of Tartu, Tartu, Estonia., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.; German Center for Cardiovascular Disease Research (DZHK), partner site Munich, Neuherberg, Germany., Polasek O; Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.; Psychiatric Hospital 'Sveti Ivan', Zagreb, Croatia., Pramstaller PP; Institute for Biomedicine, Eurac Research, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.; Department of Neurology, General Central Hospital, Bolzano, Italy.; Department of Neurology, University of Lübeck, Lübeck, Germany., Nguyen QT; Mathematical and Statistical Computing Laboratory, Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Ren M; Fujian Key Laboratory of Geriatrics, Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China., Rettig R; Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany., Rice K; Department of Biostatistics, University of Washington, Seattle, WA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Ried JS; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Riese H; Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ripatti S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Robino A; Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Rudan I; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Ruggiero D; Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Napoli, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Saba Y; Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria., Sala CF; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy., Salomaa V; Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Sarin AP; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria., Shrine N; Department of Health Sciences, University of Leicester, Leicester, UK., Siscovick D; The New York Academy of Medicine, New York, NY, USA., Smith AV; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Icelandic Heart Association, Kopavogur, Iceland., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Sõber S; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Sorice R; Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Napoli, Italy., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK., Stott DJ; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK., Strachan DP; Population Health Research Institute, St George's, University of London, London, UK., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Centre for Molecular Medicine, L8:03, Karolinska Universitetsjukhuset, Solna, Sweden., Sundström J; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden., Swertz MA; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Teumer A; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, UK., Tomaszewski M; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; Division of Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Toniolo D; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy., Traglia M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Tuomilehto J; Dasman Diabetes Institute, Dasman, Kuwait.; Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Tzourio C; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, CHU Bordeaux, Bordeaux, France., Uitterlinden AG; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Vaez A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Vergnaud AC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Verwoert GC; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Vitart V; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK., Völker U; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Vollenweider P; Department of Internal Medicine, University Hospital, CHUV, Lausanne, Switzerland., Vuckovic D; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.; Experimental Genetics Division, Sidra Medical and Research Center, Doha, Qatar., Watkins H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wild SH; Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Willemsen G; Department of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands., Wilson JF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Wright AF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Zemunik T; Department of Biology, Faculty of Medicine, University of Split, Split, Croatia., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK., Attia JR; Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia., Butterworth AS; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Conen D; Division of Cardiology, University Hospital, Basel, Switzerland.; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Cucca F; Institute of Genetic and Biomedical Research, National Research Council (CNR), Monserrato, Cagliari, Italy.; Department of Biomedical Sciences, University of Sassari, Sassari, Italy., Danesh J; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK., Hayward C; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK., Howson JMM; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Lakatta EG; Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Melander O; Department Clinical Sciences, Malmö, Lund University, Malmö, Sweden., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Palmer CNA; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK., Risch L; Labormedizinisches Zentrum Dr. Risch, Schaan, Liechtenstein.; Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.; University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Scott RJ; Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia., Sever P; National Heart and Lung Institute, Imperial College London, London, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Zeggini E; Wellcome Trust Sanger Institute, Hinxton, UK., Levy D; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK., Newton-Cheh C; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Brown MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia., Hung AM; Tennessee Valley Healthcare System (Nashville VA) & Vanderbilt University, Nashville, TN, USA., O'Donnell CJ; VA Boston Healthcare, Section of Cardiology and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Edwards TL; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Tzoulaki I; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Barnes MR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK., Wain LV; Department of Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK. p.elliott@imperial.ac.uk.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. p.elliott@imperial.ac.uk.; National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare NHS Trust and Imperial College London, London, UK. p.elliott@imperial.ac.uk.; UK Dementia Research Institute (UK DRI) at Imperial College London, London, UK. p.elliott@imperial.ac.uk.; Health Data Research-UK London substantive site, London, UK. p.elliott@imperial.ac.uk., Caulfield MJ; 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Publikováno v:
Nature genetics [Nat Genet] 2018 Oct; Vol. 50 (10), pp. 1412-1425. Date of Electronic Publication: 2018 Sep 17.
Autor:
Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Kraja AT; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Chasman DI; Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Guo X; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Franceschini N; Epidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, North Carolina, United States of America., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Sim X; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore., Vojinovic D; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Musani SK; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America., Li C; Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, Georgia, United States of America., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Schwander K; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Richard MA; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Noordam R; Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Aschard H; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.; Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France., Bartz TM; Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, Washington, United States of America., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America., Dorajoo R; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore., Fisher V; Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Hartwig FP; Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom., Horimoto ARVR; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil., Lohman KK; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Manning AK; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tajuddin SM; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Alver M; Estonian Genome Center, University of Tartu, Tartu, Estonia., Boissel M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America., Campbell A; Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Chai JF; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore., Chen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden., Divers J; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Gao C; Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Goel A; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom., Hagemeijer Y; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Medical Genetics Section, Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, United Kingdom., He M; Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Hsu FC; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; University of Tampere, Tampere, Finland., Kasturiratne A; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Kühnel B; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Laguzzi F; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Matoba N; Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom., Riaz M; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Instititute of Bioinformatics, Lausanne, Switzerland., Robino A; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Said MA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Scott RA; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Sofer T; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States of America., Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Tayo BO; Department of Public Health Sciences, Loyola University Chicago, Maywood, Illinois, United States of America., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden., Vitart V; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Wang Y; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America., Ware EB; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America., Warren HR; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom., Weiss S; Interfaculty Institute for Genetics and Functional genomics, University Medicine Ernst Moritz Arndt University Greifsald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America., Yanek LR; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom., Zhao JH; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Afaq S; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom., Amin N; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Amini M; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Boerwinkle E; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, United States of America.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America., Borecki I; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Broeckel U; Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America., Brown M; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom., Brumat M; Department of Medical Sciences, University of Trieste, Trieste, Italy., Burke GL; Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Canouil M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Chakravarti A; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Charumathi S; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Ida Chen YD; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Connell JM; Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland, United Kingdom., Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America., de Las Fuentes L; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Cardiovascular Division, Department of Medicine, Washington University, St. Louis, Missouri, United States of America., de Mutsert R; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Deng X; Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Ding J; Center on Diabetes, Obesity, and Metabolism, Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America., Duan Q; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America., Eaton CB; Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America., Ehret G; Cardiology, Geneva University Hospital, Geneva, Switzerland., Eppinga RN; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America., Felix SB; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Forouhi NG; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Forrester T; The Caribbean Institute for Health Research (CAIHR), University of the West Indies, Mona, Jamaica., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Friedlander Y; Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel., Gandin I; Department of Medical Sciences, University of Trieste, Trieste, Italy., Gao H; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Gigante B; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Gu CC; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Gu D; Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Hagenaars SP; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Psychology, The University of Edinburgh, Edinburgh, United Kingdom., Hallmans G; Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Västerbotten, Sweden., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America., He J; Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.; Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America., Heikkinen S; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore., Hirata M; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan., Howard BV; MedStar Health Research Institute, Hyattsville, Maryland, United States of America.; Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington, DC, United States of America., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands., John U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute of Social Medicine and Prevention, University Medicine Greifswald, Greifswald, Germany., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan., Khor CC; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Department of Biochemistry, National University of Singapore, Singapore, Singapore., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Koh WP; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil., Kritchevsky SB; Sticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Kubo M; Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Lakka TA; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Langefeld CD; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom., Lewis CE; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Li Y; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Lin S; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Liu J; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore., Liu J; WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore., Louie T; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., McKenzie CA; The Caribbean Institute for Health Research (CAIHR), University of the West Indies, Mona, Jamaica., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia., Milaneschi Y; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America., Momozawa Y; Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan., Nalls MA; Data Tecnica International, Glen Echo, Maryland, United States of America.; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, Washington, United States of America., Norris JM; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, United States of America., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Palmer ND; Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Perls T; Geriatrics Section, Boston University Medical Center, Boston, Massachusetts, United States of America., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden., Peters A; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg, Germany., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America., Poulter N; School of Public Health, Imperial College London, London, London, United Kingdom., Raffel LJ; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, California, United States of America., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Roll K; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Rose LM; Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America., Rosendaal FR; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Rotter JI; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Schmidt CO; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Schreiner PJ; Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America., Schupf N; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Sever PS; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Shi Y; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Sidney S; Division of Research, Kaiser Permanente of Northern California, Oakland, California, United States of America., Sims M; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America., Sitlani CM; Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, Washington, United States of America., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Tan NYQ; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Tang H; Department of Genetics, Stanford University, Stanford, California, United States of America., Taylor KD; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Teo YY; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Turner ST; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Vollenweider P; Service of Internal Medicine, Department of Internal Medicine, University Hospital, Lausanne, Switzerland., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Wang L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Wang YX; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Williams C; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Yao J; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Yu C; Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America., Zonderman AB; Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America., Becker DM; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Bowden DW; Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Imperial College Healthcare NHS Trust, London, United Kingdom.; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Psychology, The University of Edinburgh, Edinburgh, United Kingdom., Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, United States of America., Farrall M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, Massachusetts, United States of America., Freedman BI; Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Froguel P; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.; Department of Genomics of Common Disease, Imperial College London, London, United Kingdom., Gasparini P; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medical Sciences, University of Trieste, Trieste, Italy., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Jonas JB; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.; Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany, Germany., Kamatani Y; Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan., Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Kooner JS; Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom.; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Imperial College Healthcare NHS Trust, London, United Kingdom.; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Kutalik Z; Swiss Instititute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Laurie CC; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America., Leander K; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Study LC; Lifelines Cohort, Groningen, The Netherlands., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Penninx BWJH; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands., Polasek O; Department of Public Health, Department of Medicine, University of Split, Split, Croatia.; Psychiatric Hospital 'Sveti Ivan', Zagreb, Croatia.; Gen-info Ltd, Zagreb, Croatia., Porteous DJ; Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., Scott J; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Wagenknecht LE; Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Wu T; Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America., Christensen K; The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark., Evans MK; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Horta BL; Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America., Liu Y; Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America., Pereira AC; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil., Psaty BM; Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington, United States of America.; Kaiser Permanente Washington, Health Research Institute, Seattle, Washington, United States of America., Ridker PM; Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., van Dam RM; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Gauderman WJ; Biostatistics, Preventive Medicine, University of Southern California, Los Angeles, California, United States of America., Zhu X; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America., Mook-Kanamori DO; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Fornage M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America., Cupples LA; Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.; The Framingham Heart Study, Framingham, Massachusetts, United States of America., Kelly TN; Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America., Fox ER; Cardiology, Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., van Duijn CM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Tai ES; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Kooperberg C; Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, Washington, United States of America., Palmas W; Medicine, Columbia University Medical Center, New York, New York, United States of America., Rice K; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Elliott P; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Levy D; The Framingham Heart Study, Framingham, Massachusetts, United States of America.; The Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Publikováno v:
PloS one [PLoS One] 2018 Jun 18; Vol. 13 (6), pp. e0198166. Date of Electronic Publication: 2018 Jun 18 (Print Publication: 2018).
Autor:
Sung YJ; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: yunju@wustl.edu., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg 93051, Germany., de Las Fuentes L; Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MO 63110, USA., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Brown MR; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USA., Kraja AT; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA., Schwander K; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA., Ntalla I; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK., Guo X; Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Franceschini N; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA., Lu Y; Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore., Sim X; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore., Vojinovic D; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Musani SK; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USA., Li C; Department of Epidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, GA 30602, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA., Kilpeläinen TO; Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Richard MA; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300RC, the Netherlands., Aslibekyan S; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Aschard H; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; Centre de Bioinformatique Biostatistique et Biologie Integrative (C3BI), Institut Pasteur, Paris 75015, France., Bartz TM; Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA 98101, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore., Liu Y; Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Manning AK; Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA., Smith AV; Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Tajuddin SM; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Tayo BO; Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA., Warren HR; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Zhao W; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA., Zhou Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA., Matoba N; Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan., Sofer T; Department of Biostatistics, University of Washington, Seattle, WA 98105, USA., Alver M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Amini M; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Boissel M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore., Chen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Divers J; Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Gandin I; Department of Medical Sciences, University of Trieste, Trieste 34137, Italy., Gao C; Department of Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Giulianini F; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Goel A; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh EH4 2XU, UK., Hartwig FP; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, Brazil., Horimoto ARVR; Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil., Hsu FC; Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Kähönen M; Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland., Kasturiratne A; Department of Public Health, University of Kelaniya, Ragama, Sri Lanka., Kühnel B; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany., Leander K; Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Department of Social Work, Tunghai University, Taichung 40705, Taiwan., Lin KH; Department of Opthalmology, Taichung Veterans General Hospital, Taichung 40705, Taiwan., 'an Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., McKenzie CA; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica., Meian H; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, Finland., Schupf N; Taub Institute for Research on Alzheimer disease and the Aging Brain, Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA., Scott RA; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Sheu WHH; Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan; School of Medicine, National Yang-ming University, Taipei, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan; Institute of Medical Technology, National Chung-Hsing University, Taichung 40705, Taiwan., Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio 70210, Finland., Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 1628655, Japan., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Varga TV; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden., Wang H; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA., Wang Y; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA., Ware EB; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA; Institute for Social Research, Research Center for Group Dynamics, University of Michigan, Ann Arbor, MI 48104, USA., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz Arndt University Greifswald, Greifswald 17487, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany., Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA., Yanek LR; General Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Afaq S; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Alfred T; Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA., Amin N; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Arking D; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore., Barr RG; Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USA., Bielak LF; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA., Boerwinkle E; Human Genetics Center, The University of Texas School of Public Health, Houston, TX 77030, USA; Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA., Bottinger EP; Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Brody JA; Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA 98101, USA., Broeckel U; Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Cabrera CP; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Cade B; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA., Caizheng Y; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China., Campbell A; Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Canouil M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Chauhan G; Centre for Brain Research, Indian Institute of Schience, Bangalore 560012, India., Christensen K; The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark., Cocca M; Department of Medical Sciences, University of Trieste, Trieste 34137, Italy., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Connell JM; Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, the Netherlands., de Silva HJ; Department of Medicine, University of Kelaniya, Ragama, Sri Lanka., Debette S; Inserm U1219 Neuroepidemiology, University of Bordeaux, Bordeaux, France; Department of Neurology, University Hospital, Bordeaux, France; Boston University School of Medicine, Boston, MA 02118, USA., Dörr M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Department of Internal Medicine B, University Medicine Greifswald, Greifswald 17475, Germany., Duan Q; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA., Eaton CB; Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI 02860, USA., Ehret G; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Division of Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece., Faul JD; Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA., Fisher VA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA., Forouhi NG; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Friedlander Y; Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem 91120, Israel., Gao H; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK., Gigante B; Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden., Graff M; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA., Gu CC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA., Gu D; Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Gupta P; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore., Hagenaars SP; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Heikkinen S; University of Eastern Finland, Institute of Biomedicine, Kuopio 70211, Finland., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore 119228, Singapore., Hirata M; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku 108-8639, Japan., Hofman A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Howard BV; MedStar Health Research Institute, Hyattsville, MD 20782, USA; Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington, DC 20057, USA., Hunt S; Cardiovascular Genetics, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84108, USA; Weill Cornell Medicine in Qatar, Doha, Qatar., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Jia Y; Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Joehanes R; Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02131, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA., Justice AE; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita 5650871, Japan; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita 5650871, Japan., Kaufman J; Epidemiology, Department of Occupational and Environmental Medicine Program, University of Washington, Seattle, WA 98105, USA., Kerrison ND; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Khor CC; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore; Department of Biochemistry, National University of Singapore, Singapore 117596, Singapore., Koh WP; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore; Duke-NUS Medical School, Singapore 169857, Singapore., Koistinen HA; Department of Health, National Institute for Health and Welfare, Helsinki 00271, Finland; Department of Medicine and Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, Finland., Kooperberg C; Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA 98109, USA., Krieger JE; Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil., Kubo M; Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland., Langefeld CD; Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Lewis CE; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA., Li Y; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA., Lim SH; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore., Lin S; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA., Liu J; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore., Liu J; WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USA., Liu K; Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Liu Y; Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research 138648, Singapore., Lohman KK; Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA., Louie T; Department of Biostatistics, University of Washington, Seattle, WA 98105, USA., Mägi R; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Human Genetics, Technische Universität München, Munich 80333, Germany., Metspalu A; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Momozawa Y; Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK., Mosley TH Jr; Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA., Munson P; Mathematical and Statistical Computing Laboratory, Center for Information Technology, NIH, Bethesda, MD 20892, USA., Murray AD; The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen AB25 2ZD, UK., Nalls MA; Data Tecnica International, Glen Echo, MD 20812, USA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA., Nasri U; Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Norris JM; Department of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, USA., North K; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA., Ogunniyi A; Department of Medicine, University of Ibadan, Ibadan, Nigeria., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Palmas WR; Internal Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Pankow JS; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Peters A; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg 85764, Germany., Peyser PA; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland., Renström F; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden; Department of Biobank Research, Umeå University, Umeå, Västerbotten 901 87, Sweden., Rice TK; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA., Ridker PM; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Robino A; Medical Genetics, IRCCS Burlo, Garofolo 34137, Italy., Robinson JG; Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, USA., Rose LM; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Rudan I; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore., Salako BL; Department of Medicine, University of Ibadan, Ibadan, Nigeria., Sandow K; Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Schmidt CO; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Schreiner PJ; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK., Seshadri S; Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA; Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA., Sever P; International Centre for Circulatory Health, Imperial College London, London W2 1PG, UK., Sitlani CM; Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA 98101, USA., Smith JA; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh EH8 9JZ, UK., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich 81377, Germany., Tang H; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Taylor KD; Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Teo YY; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore; Life Sciences Institute, National University of Singapore, Singapore, Singapore 117456, Singapore; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore 117456, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117546, Singapore., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore., Uitterlinden AG; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany., Wang L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA., Wang YX; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China 100730, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China., Williams C; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA., Wilson G; Jackson Heart Study, Department of Public Health, Jackson State University, Jackson, MS 39213, USA., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA., Yao J; Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA; Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA., Zonderman AB; Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Becker DM; General Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK., Chen YI; Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., de Faire U; Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK., Esko T; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, MA 02142, USA., Farrall M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Forrester T; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica., Franks PW; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden; Harvard T.H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, MA 02115, USA; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Västerbotten 901 85, Sweden., Freedman BI; Division of Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Froguel P; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France; Department of Genomics of Common Disease, Imperial College London, London W12 0NN, UK., Gasparini P; Department of Medical Sciences, University of Trieste, Trieste 34137, Italy; Division Experimental Genetics, Sidra, Doha 26999, Qatar., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg 85764, Germany., Horta BL; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, Brazil., Hung YJ; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taipei 11490, Taiwan., Jonas JB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim 68167, Germany., Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 1628655, Japan., Kooner JS; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Lifes Sciences, University of Tampere, Tampere 33014, Finland., Liang KW; School of Medicine, National Yang-ming University, Taipei, Taiwan; Cardiovascular Center, Taichung Veterans General Hospital, Taichung 40705, Taiwan; Department of Medicine, China Medical University, Taichung 40705, Taiwan., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Newman AB; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Pereira AC; Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil; Genetics, Harvard Medical School, Boston, MA 02115, USA., Redline S; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA., Rettig R; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Institute of Physiology, University Medicine Greifswald, Greifswald 17495, Germany., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Scott J; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Wagenknecht LE; Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Weir DR; Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA., Wickremasinghe AR; Department of Public Health, University of Kelaniya, Ragama, Sri Lanka., Wu T; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA., Kamatani Y; Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA 98105, USA., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA., Cooper RS; Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA., Evans MK; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Gudnason V; Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Kardia SLR; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA., Kritchevsky SB; Sticht Center for Health Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Levy D; Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Psaty BM; Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA 98101, USA; Kaiser Permanente Washington, Health Research Institute, Seattle, WA 98101, USA., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore., Sims M; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USA., Arnett DK; Dean's Office, University of Kentucky College of Public Health, Lexington, KY 40536, USA., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden 2300RC, the Netherlands., Kelly TN; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA., Fox ER; Cardiology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA., van Duijn CM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Tai ES; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Duke-NUS Medical School, Singapore 169857, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore., Loos RJF; Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA; Icahn School of Medicine at Mount Sinai, The Mindich Child Health and Development Institute, New York, NY 10029, USA., Reiner AP; Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA 98109, USA., Rotter JI; Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA; Genomic Outcomes, Department of Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Zhu X; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA., Bierut LJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Gauderman WJ; Division of Biostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90032, USA., Caulfield MJ; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK., Rice K; Department of Biostatistics, University of Washington, Seattle, WA 98105, USA., Munroe PB; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK., Morrison AC; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USA., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA., Chasman DI; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address: dchasman@research.bwh.harvard.edu.
Publikováno v:
American journal of human genetics [Am J Hum Genet] 2018 Mar 01; Vol. 102 (3), pp. 375-400. Date of Electronic Publication: 2018 Feb 15.
Autor:
Wu C; School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA; wuche@oregonstate.edu., Shlipak MG; Department of Medicine, University of California, San Francisco, California, USA.; Department of Medicine, Kidney Health Research Collaborative at the San Francisco VA Medical Center, San Francisco, California, USA., Stawski RS; School of Social and Human Health Sciences, Oregon State University, Corvallis, Oregon, USA., Peralta CA; Department of Medicine, University of California, San Francisco, California, USA.; Department of Medicine, Kidney Health Research Collaborative at the San Francisco VA Medical Center, San Francisco, California, USA., Psaty BM, Harris TB; Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA., Satterfield S; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Shiroma EJ; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Newman AB; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Odden MC; School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA.
Publikováno v:
American journal of hypertension [Am J Hypertens] 2017 Feb; Vol. 30 (2), pp. 151-158. Date of Electronic Publication: 2016 Sep 06.
Autor:
Liu C; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.; Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Kraja AT; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA., Franceschini N; Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA., Rice K; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Morrison AC; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston Texas, USA., Lu Y; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Weiss S; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst Moritz Arndt University Greifswald, Greifswald, Germany., Guo X; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA., Palmas W; Division of General Medicine, Columbia University Medical Center, New York, New York, USA., Martin LW; George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Chen YD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA., Surendran P; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Drenos F; Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Department of Health Sciences, University of Leicester, Leicester, UK., Auer PL; Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Chu AY; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Giri A; Vanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Lin LA; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA., Stafford JM; Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Mei H; Department of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA., Yao J; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA., Voorman A; Bill and Melinda Gates Foundation, Seattle, Washington, USA., Larson MG; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.; Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA.; Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, USA., Grove ML; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston Texas, USA., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Hwang SJ; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Chen H; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Huan T; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Kosova G; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA., Stitziel NO; Division of Cardiology, Department of Medicine and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., Kathiresan S; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA., Samani N; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK., Schunkert H; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany., Deloukas P; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Li M; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA., Fuchsberger C; Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated with the University of Lübeck, Lübeck, Germany)., Pattaro C; Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated with the University of Lübeck, Lübeck, Germany)., Gorski M; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Papanicolaou GJ; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Rossouw JE; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA., Kardia SL; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA., Bouchard C; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA., Raffel LJ; Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Uitterlinden AG; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Franco OH; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Vasan RS; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.; Department of Preventive Medicine, Boston University School of Medicine, Boston, Massachusetts, USA., O'Donnell CJ; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.; Cardiology Section, Department of Medicine, Boston Veterans Administration Healthcare, Boston, Massachusetts, USA.; Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA., Liu K; Northwestern University School of Medicine, Chicago, Illinois, USA., Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Gottesman O; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Daw EW; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Ganesh S; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Salfati E; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Harris TB; Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA., Launer LJ; Neuroepidemiology Section, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA., Dörr M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Felix SB; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Rettig R; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute of Physiology, University of Greifswald, Greifswald, Germany., Völzke H; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; DZD (German Center for Diabetes Research), site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Kim E; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Lee IT; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Tsosie KS; Vanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Edwards DR; Vanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Liu Y; Epidemiology and Prevention Center for Genomics and Personalized Medicine Research, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA., Völker U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst Moritz Arndt University Greifswald, Greifswald, Germany., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston Texas, USA., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Reiner AP; Department of Epidemiology, University of Washington, Seattle, Washington, USA., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Borecki IB; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA., Edwards TL; Vanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Health Services, University of Washington, Seattle, Washington, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Loos RJ; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Fornage M; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA., Ehret GB; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Cardiology, Geneva University Hospitals, Geneva, Switzerland., Newton-Cheh C; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA., Levy D; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
Publikováno v:
Nature genetics [Nat Genet] 2016 Oct; Vol. 48 (10), pp. 1162-70. Date of Electronic Publication: 2016 Sep 12.
Autor:
Sung YJ; Division of Biostatistics, Washington University, St. Louis, Missouri, United States of America., Winkler TW; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Manning AK; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.; Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America., Aschard H; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Fornage M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Lin LA; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Richard M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Bartz TM; Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America.; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America., Psaty BM; Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America.; Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America., Hayward C; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, United Kingdom., Polasek O; Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom., Marten J; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, United Kingdom., Rudan I; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Kraja AT; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Deng X; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Fisher VA; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Zhou Y; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Bielak LF; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America., Smith J; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America., Huffman JE; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, United Kingdom., Padmanabhan S; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.; Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom., Smith BH; Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.; Division of Population Health Sciences, University of Dundee, Dundee, United Kingdom., Ding J; Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Liu Y; Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Lohman K; Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles, United States of America., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles, United States of America., Rice TK; Division of Biostatistics, Washington University, St. Louis, Missouri, United States of America., Arnett D; Department of Epidemiology, University of Alabama-Birmingham, Birmingham, Alabama, United States of America., Schwander K; Division of Biostatistics, Washington University, St. Louis, Missouri, United States of America., Guo X; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Palmas W; Department of Medicine, Columbia University Medical Center, New York, New York, United States of America., Rotter JI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Alfred T; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Loos RJ; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands., Franco OH; Cardiovascular Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands., Vojinovic D; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands., Chasman DI; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America., Ridker PM; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America., Rose LM; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America., Kardia S; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America., Zhu X; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America., Rice K; Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America.; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America., Borecki IB; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Rao DC; Division of Biostatistics, Washington University, St. Louis, Missouri, United States of America., Gauderman WJ; Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.; Framingham Heart Study, Framingham, Massachusetts, United States of America.
Publikováno v:
Genetic epidemiology [Genet Epidemiol] 2016 Jul; Vol. 40 (5), pp. 404-15. Date of Electronic Publication: 2016 May 27.
Autor:
Rosano C; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania; rosanoc@edc.pitt.edu., Abebe KZ; Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania;, Aizenstein HJ; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania;, Boudreau R; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania;, Jennings JR; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania;, Venkatraman V; Department of Bioengineeringm University of Pittsburgh, Pittsburgh, Pennsylvania;, Harris TB; National Institutes of Health, National Institute on Aging, National Institutes of Health, Bethesda, MD;, Yaffe K; Department of Psychiatry, University of California-San Francisco, San Francisco, California;, Satterfield S; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee., Newman AB; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania;
Publikováno v:
American journal of hypertension [Am J Hypertens] 2015 Mar; Vol. 28 (3), pp. 326-34. Date of Electronic Publication: 2014 Aug 26.
Autor:
Torjesen AA; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.)., Sigurðsson S; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.)., Westenberg JJ; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.)., Gotal JD; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.)., Bell V; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.)., Aspelund T; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.)., Launer LJ; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.)., de Roos A; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.)., Gudnason V; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.)., Harris TB; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.)., Mitchell GF; From the Cardiovascular Engineering, Inc, Norwood, MA (A.A.T., J.D.G., V.B.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., V.G.); Leiden University Medical Center, Leiden, The Netherlands (J.J.M.W., A.d.R.); University of Iceland, Reykjavik, Iceland (T.A., V.G.); and National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L., T.B.H.). GaryFMitchell@mindspring.com.
Publikováno v:
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2014 Oct; Vol. 64 (4), pp. 756-61. Date of Electronic Publication: 2014 Jul 14.
Autor:
Simino J; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: jeannette@wubios.wustl.edu., Shi G; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Ehret GB; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, Geneva 1211, Switzerland., Gu X; Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA., Guo X; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Hwang SJ; Framingham Heart Study, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA., Sijbrands E; Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands., Smith AV; Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland., Verwoert GC; Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands., Bragg-Gresham JL; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Cadby G; Centre for Genetic Origins of Health and Disease, University of Western Australia, Nedlands, WA 6009, Australia; Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada., Chen P; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore., Cheng CY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore., Corre T; Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., de Boer RA; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Goel A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Johnson T; Clinical Pharmacology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Khor CC; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Paediatrics, National University Health System, Singapore 119074, Singapore., Lluís-Ganella C; Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 30101, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33101, Finland., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Sim X; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Centre for Molecular Epidemiology, National University of Singapore, Singapore 119260, Singapore., Sõber S; Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Zhao JH; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Amin N; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands., Boerwinkle E; Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA., Dehghan A; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands., Eiriksdottir G; Icelandic Heart Association, 201 Kopavogur, Iceland., Elosua R; Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain; Epidemiology and Public Health Network (CIBERESP), 08036 Barcelona, Spain., Franco OH; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany., Harris TB; Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, USA., Hercberg S; U557 Institut National de la Santé et de la Recherche Médicale, U1125 Institut National de la Recherche Agronomique, Université Paris 13, 93000 Bobigny, France., Hofman A; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands., James AL; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia., Johnson AD; Framingham Heart Study, Framingham, MA 01702, USA; Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33521, Finland., Khaw KT; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK., Kutalik Z; Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Larson MG; Framingham Heart Study, Framingham, MA 01702, USA; Department of Mathematics, Boston University, Boston, MA 02215, USA., Launer LJ; Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, USA., Li G; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA., Liu J; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore., Liu K; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Morrison AC; Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA., Navis G; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Ong RT; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore., Papanicolau GJ; Division of Cardiovascular Sciences, National Heart, Lung, & Blood Institute, NIH, Bethesda, MD 20892, USA., Penninx BW; Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, the Netherlands; Department of Psychiatry, Leiden University Medical Centre, 2333 ZD Leiden, the Netherlands; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Department of Health Services, University of Washington, Seattle, WA 98195, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA., Raffel LJ; Medical Genetics Institute, Cedars-Sinai Medical Center, Pacific Theatres, Los Angeles, CA 90048, USA., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20521, Finland., Rice K; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., Rivadeneira F; Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato 09042, Italy., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Siscovick DS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA., Stolk RP; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Uitterlinden AG; Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Netherland Genomics Inititiative, Netherlands Center for Healthy Aging, The Hague 2509, the Netherlands., Vaidya D; Department of Medicine, Johns Hopkins University, Baltimore, MD 21202, USA., van der Klauw MM; Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Vasan RS; Framingham Heart Study, Framingham, MA 01702, USA; Divisions of Epidemiology and Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA., Vithana EN; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore; Neuroscience and Behavioural Disorders (NBD) Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17487 Greifswald, Germany., Völzke H; Institute for Community Medicine, University of Greifswald, 17487 Greifswald, Germany., Watkins H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Young TL; Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA; Division of Neuroscience, Duke-National University of Singapore, Singapore 169857, Singapore., Aung T; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore., Bochud M; Institute of Social and Preventive Medicine, Lausanne University Hospital, 1010 Lausanne, Switzerland., Farrall M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Hartman CA; Interdisciplinary Center for Pathology of Emotions, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Laan M; Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Lakatta EG; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Bethesda, MD 21224, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 30101, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33101, Finland., Loos RJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lucas G; Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain., Meneton P; U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Paris 75006, France., Palmer LJ; Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada., Rettig R; Institute of Physiology, University of Greifswald, 17495 Karlsburg, Germany., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Medicine, National University Health System and Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117543, Singapore; Genome Institute of Singapore, A(∗)STAR, Singapore 138672, Singapore., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Durrer Center for Cardiogenetic Research, 3501 DG Utrecht, the Netherlands., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Wijmenga C; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Wong TY; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore., Fornage M; Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA., Gudnason V; Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland., Levy D; Framingham Heart Study, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Boston University School of Medicine, Boston, MA 02118, USA., Palmas W; Department of Medicine, Columbia University, New York, NY 10032, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA., van Duijn CM; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Netherland Genomics Inititiative, Netherlands Center for Healthy Aging, The Hague 2509, the Netherlands; Netherland Genomics Initiative, Centre for Medical Systems Biology, 2300 RC Leiden, the Netherlands., Witteman JC; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: aravinda@jhmi.edu., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA; Departments of Psychiatry, Genetics, and Mathematics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Publikováno v:
American journal of human genetics [Am J Hum Genet] 2014 Jul 03; Vol. 95 (1), pp. 24-38. Date of Electronic Publication: 2014 Jun 19.