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Autor:
Ewen MacDonald
Publikováno v:
Acta Pharmacologica et Toxicologica. 54:76-80
The pithed rat preparation was used to study the effects of copper (as cupric chloride) on the release and re-uptake of noradrenaline from sympathetic nerves. At the highest concentration which could be tested without failure of the preparation, ther
Publikováno v:
Acta Pharmacologica et Toxicologica. 56:63-68
The interaction between chlorpromazine (CPZ) and lithium on renal concentrating ability was studied in rats fed a Li-containing diet for 8 weeks (plasma-Li 0.6-0.7 mmol/l). CPZ (15 mg/kg daily orally) reduced the polydipsia and increased the ability
Publikováno v:
American Journal of Nephrology. 28:8-13
Background/Aims: There are two major pathophysiologic processes involved in the development of hypertension: (1) expanded extracellular fluid volume and (2) vasoconstriction. We have developed a model of preeclampsia in the rat, in which excessive vo
Autor:
Hiroshi Hayakawa, Yasunobu Hirata, Kenji Kangawa, Etsu Suzuki, Hisayuki Matsuo, Tsuneaki Sugimoto, Hiroaki Matsuoka
Publikováno v:
Journal of Cardiovascular Pharmacology. 2:283-290
To explore the mechanisms of the renal effects of neutral endopeptidase (NEP) inhibition, the effects of an NEP inhibitor, candoxatril (UK 79,300; UK), in Dahl salt-sensitive (SS) and salt-resistant (SR) rats were examined. UK dose-dependently decrea
Publikováno v:
Journal of Autonomic Pharmacology. 14:37-48
1. Power spectral analysis of the frequency of wave-forms of blood pressure and heart rate was used to characterize short-term fluctuations of these parameters in three strains of conscious Lyon rat, normotensive (LL and LN) and hypertensive LH. 2. A
Publikováno v:
Neuropharmacology. 31:777-782
The possibility that mu-opioid-induced tachycardia and bradycardia could be mediated by different subtypes of the mu-receptor was studied in conscious Sprague-Dawley rats. The selective mu-receptor agonist dermorphin and its analog, TAPS (Tyr-D-Arg-P
Autor:
Martin Pfaffendorf, Doris Wilhelm, P. A. Van Zwieten, Mj Mathy, H.R. Schwietert, Bob Wilffert
Publikováno v:
Journal of autonomic pharmacology, 12(3), 125-136
Journal of autonomic pharmacology, 12(3), 125-136. Wiley-Blackwell
Journal of autonomic pharmacology, 12(3), 125-136. Wiley-Blackwell
1. In the present study, we tested the hypothesis that in the pithed rat preparation two subtypes of the alpha 1-adrenoceptor are linked to two different signal transduction mechanisms, both of which contribute to vasoconstriction, one facilitating C
Publikováno v:
Journal of Cardiovascular Pharmacology. 19:958-965
Isolated tail arteries from Wistar rats, prelabeled with [3H]norepinephrine (NE) were subjected to electrical field stimulation (24 pulses at 0.4 Hz and 200 mA). Both NE release and vasoconstriction were measured in parallel. The selective alpha 2-ad
Autor:
Reza Tabrizchi, Chris R. Triggle
Publikováno v:
Journal of Cardiovascular Pharmacology. 19:562-567
The interrelationship between the effects of the angiotensin converting enzyme inhibitor captopril and the calcium channel antagonist nifedipine on alpha-mediated vasoconstriction elicited by the administration of the full and partial alpha 1-adrenoc
Publikováno v:
Journal of Cardiovascular Pharmacology. 19:460-463
Hemodynamic responses to intravenous (i.v.) injection of DPMA [N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl] adenosine); PD 125,944], a potent adenosine agonist with a 32-fold selectivity for the adenosine-2 (A2) receptor subtype, were charact