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Autor:
Terrance P. Snutch, Changiz Taghibiglou, Sathiya Sekar, John G. Howland, Venkat Gopalakrishnan, Quentin Greba, Wendie N. Marks
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 47:1530-1536
Insulin-mediated signalling in the brain is critical for neuronal functioning. Insulin resistance is implicated in the development of some neurological diseases, although changes associated with absence epilepsy have not been established yet. Therefo
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 38:143-162
The dynamics of aging and type 2 diabetes (T2D) disease progression were investigated in normal [Wistar-Kyoto (WKY)] and diabetic [Goto-Kakizaki (GK)] rats and a mechanistic disease progression model was developed for glucose, insulin, and glycosylat
Autor:
A. R. Moedas, Elsa Nunes, Pedro Monteiro, C. Amaral, T. Louro, Joana Crisóstomo, Paulo Matafome, Raquel Seiça, A. Cipriano, Lisa Rodrigues
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Non-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as we
Autor:
Kimberly G. Freeman, Emily W Kelso, Darin E. Olson, Adam G. Campbell, William P. Flatt, Marty H Porter, Peter M. Thulé
Publikováno v:
Molecular Therapy. 16:1235-1242
Previous studies of hepatic insulin gene therapy (HIGT) focused on glycemic effects of insulin produced from hepatocytes. In this study, we extend the observations of glycemic control with metabolically regulated HIGT to include systemic responses an
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:1216-1223
Streptozotocin (STZ)-induced diabetes can modulate dopamine (DA) neurotransmission and thereby modify the behavioral effects of drugs acting on DA systems. Insulin replacement, and in some conditions repeated treatment with amphetamine, can partially
Publikováno v:
Journal of Cardiovascular Pharmacology. 29:586-592
The JCR:LA-cp rat exhibits the obesity/insulin resistance/hypertriglyceridemia syndrome in an extreme form. These normotensive rats spontaneously develop advanced atherosclerosis and ischemic myocardial lesions. The calcium channel antagonist, nisold
Autor:
Hironobu Kakuta, Nigishi Hotta, Tomohiro Hara, Keiko Naruse, Fumihiko Sakakibara, Hideo Fukasawa, Yoji Hamada, Nobuo Sakamoto, Koichi Mori, Jiro Nakamura, Naoki Koh
Publikováno v:
European Journal of Pharmacology. 313:201-209
To investigate the pathogenesis of diabetic neuropathy in non-insulin-dependent diabetes mellitus, Otsuka Long-Evans Tokushima Fatty rats, an animal model of non-insulin-dependent diabetes mellitus, and non-diabetic Long-Evans Tokushima Otsuka rats w
Publikováno v:
Biochemical Pharmacology. 44:379-382
The antihyperlipidaemic agent benfluorex [1-(3-trifluoromethylphenyl)-2-(2-benzoyl-oxyethyl)-aminopropane] and its metabolite S422 [1-(3-trifluoromethylphenyl)-2-(2-hydroxyethyl)-aminopropane] were examined for an acute (after 1–2 hr) effect on glu
Autor:
Gérard Ribes, Gyslaine Bertrand, Marie-Madeleine Loubatières-Mariani, Pierre Petit, René Gross
Publikováno v:
European Journal of Pharmacology. 214:159-163
The effect of cibenzoline succinate, a new antiarrhythmic agent, was studied on insulin secretion in rats. Experiments were performed both in vivo and in vitro using two preparations: the isolated perfused pancreas and isolated islets. In anaesthetiz
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 69:1178-1183
The influence of dopamine as compared with dobutamine on glucose homeostasis has been assessed in thyroidectomized euthyroid rats. Both sympathomimetic agents were given intravenously over 6 h at four dosages, varying from 2 to 30 μg∙kg−1∙min