Zobrazeno 91 - 100
of 264
pro vyhledávání: '"Blood drug"'
Autor:
Ying Li, Mingyuang Li, Xiangyang Xie, Wen Lin, Chuanfeng Xing, Hui Zhang, Zhenbo Yang, Yanfang Yang, Yang Yang, Qiang Chi, Zhiping Li
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 5, p e0125953 (2015)
PLoS ONE, Vol 10, Iss 5, p e0125953 (2015)
Poor patient compliance, untoward reactions and unstable blood drug levels after the bolus administration are impeding the pharmacotherapy for insobriety. A long-acting preparation may address these limitations. The aim of this paper was to further i
Autor:
Katsumi Iga
Publikováno v:
Journal of pharmaceutical sciences. 104(4)
Using a three-compartment physiologically based pharmacokinetic (PBPK) model and a tube model for hepatic extraction kinetics, equations for calculating blood drug levels (Cb s) and hepatic blood drug levels (Chb s, proportional to actual hepatic dru
Publikováno v:
Nephrology Dialysis Transplantation. 21:1848-1854
Background Severe steroid-dependent nephrotic syndrome (SDNS) is a common type of nephrotic syndrome (NS) observed in childhood. Steroid-sparing agents such as calcineurin inhibitors (CNIs) are used to avoid steroid toxicity in SDNS. Tacrolimus (TAC)
Autor:
Ken-ichi Inui, Masahide Fukudo, Yasuhiro Ogura, Satohiro Masuda, Sachio Fukatsu, Toshiya Katsura, Fumitaka Oike, Yasutsugu Takada, Koichi Tanaka, Ikuko Yano
Publikováno v:
Clinical Pharmacology & Therapeutics. 78:168-181
Background The calcineurin inhibitors tacrolimus and cyclosporine (INN, ciclosporin) have been widely used to prevent allograft rejection after transplantation. We investigated pharmacodynamic properties of the 2 drugs and their clinical relevance in
Autor:
Jørgen G. Bramness, Jørg Mørland, Harald Breilid, Svetlana Skurtveit, Margaretha Gulliksen, Vidar M. Steen
Publikováno v:
European Journal of Clinical Pharmacology. 61:499-506
The aim of the present study was to investigate if subjects with one normal and one non-functional CYP2C19 allele (intermediate metabolizers; IMs) metabolized carisoprodol differently than individuals with two normal CYP2C19 alleles (extensive metabo
Autor:
Dennis J. Crouch
Publikováno v:
Forensic Science International. 150:165-173
The potential to use oral fluid as a drug-testing specimen has been the subject of considerable scientific interest. The ease with which specimens can be collected and the potential for oral fluid (OF) drug concentrations to reflect blood-drug concen
Publikováno v:
Journal of Analytical Toxicology. 29:223-228
The aim of this study was to investigate the early-phase postmortem redistribution of the enantiomers of citalopram (CIT) and its metabolites demethylcitalopram (DCIT) and didemethylcitalopram (DDCIT) in a rat model. Furthermore, we wanted to examine
Autor:
Sue Simkin, David Gunnell, Pauline Turnbull, Keith Hawton, Olive Bennewith, Lesley Sutton, Navneet Kapur
Publikováno v:
British Journal of Clinical Pharmacology. 59:207-212
AIMS: To examine in detail a series of coproxamol overdose deaths in order to provide information that will assist in the development of strategies to prevent such fatalities. METHOD: Inquest records in 24 coroners' jurisdictions in England on deaths
Autor:
J. Matthew Lacy, Richard C. Harruff, Corinne L. Fligner, Barry K. Logan, John Howard, Norman Thiersch, Jayne E. Clarkson
Publikováno v:
Journal of Forensic Sciences. 49:1-5
We reviewed a series of 66 deaths in Washington State between 1995-2000 in which tramadol (Ultram and Ultracet, Ortho-McNeil) was detected in the decedent's blood, in order to assess the role tramadol was determined to have played. Additionally, we r
Publikováno v:
Drug Delivery. 12:27-33
The aim of the study was to determine penetration properties of Famotidine fro the formulations through colon adenocarcinoma (Caco)-2 cell monolayers and to compare in vitro with in vivo test results. It also aimed to determine the effect of particle