Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ronald L. Hanson"'
Autor:
Richard Doyle, Robert M. Johnston, Wei Ding, Yeoun jin Kim, Changhong Wan, Yeung Y. Chan, Mian Gao, Olav Lyngberg, James William Bryson, Deepa Calambur, Mark R. Witmer, Stanley R. Krystek, Ronald L. Hanson, Ehrlic Lo, Steven H. Chan, Animesh Goswami, Nuria de Mas, Steven L. Goldberg, Antonio Ramirez
Publikováno v:
Bioconjugate chemistry. 27(5)
A disulfide-bridged peptide drug development candidate contained two oligopeptide chains with 11 and 12 natural amino acids joined by a disulfide bond at the N-terminal end. An efficient biotechnology based process for the production of the disulfide
Publikováno v:
Enzyme and Microbial Technology. 48:445-453
N-Cbz-4,5-dehydro-L-prolineamide or N-Boc-4,5-dehydro-L-prolineamide are alternative key intermediates for the synthesis of saxagliptin, a dipeptidyl peptidase IV (DPP4) inhibitor recently approved for treatment of type 2 diabetes mellitus. An effici
Autor:
Robert J. Johnston, Ramesh N. Patel, Ronald L. Hanson, Jeffrey M. Howell, Amit Banerjee, Rapheal Ko, Mary-Jo Donovan, Animesh Goswami, Dana L Cazzulino, Steven L. Goldberg, David B. Brzozowski, Venkata B. Nanduri, Thomas P. Tully
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 30:252-259
There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand by pharmaceutica
Autor:
Laporte Thomas L, John M. Wasylyk, Ronald L. Hanson, Ramesh N. Patel, Animesh Goswami, Kishta Katipally, Hyei-Jha Chung, Venkata B. Nanduri
Publikováno v:
Enzyme and Microbial Technology. 28:632-636
Three different biochemical approaches were used for the synthesis of ethyl 5-(S)-hydroxyhexanoate 1 and 5-(S)-hydroxyhexanenitrile 2. In the first approach, ethyl 5-oxo-hexanoate 3 and 5-oxo-hexanenitrile 4 were reduced by Pichia methanolica (SC 161
Autor:
Shankar Swaminathan, Ramesh N. Patel, Clyde G. McNamee, John J. Venit, Larry W Parker, Venkata B. Nanduri, Robert M. Johnston, Thomas P. Tully, David B. Brzozowski, Ronald L. Hanson, Laporte Thomas L, Chien-Kuang Chen, Dana L Cazzulino, Steven L. Goldberg, Ko Raphael Y, Amit Banerjee
Publikováno v:
Enzyme and Microbial Technology. 27:376-389
[4S-(4I,7I,10aJ)]1-Octahydro-5-oxo-4-[phenylmethoxy)carbonyl]amino]-7H-pyrido-[2,1-b] [1,3]thiazepine-7-carboxylic acid methyl ester (BMS-199541-01) is a key chiral intermediate for the synthesis of Omapatrilat (BMS-186716), a new vasopeptidease inhi
Autor:
Bang-Chi Chen, Andrew Rusowicz, Ronald F Eiring, Francis J. Okuniewicz, Valerie Zannella, Kenneth J. Natalie, Shawn K. Pack, Ramesh N. Patel, Steven R. Schwarz, Kai S Tse, John J. Venit, Susan C Durand, John M. Wasylyk, Bruce T Lotz, Keith Ramig, Ronald L. Hanson, John C. Harris, William L. Parker, Shankar Swaminathan, Victor W. Rosso, David A. Lust, Mary Jo Donovan, Laszlo J. Szarka, Mark Liu, Laporte Thomas L, Michael A. Montana, Dana L Cazzulino, Venkata B. Nanduri, Peter J. Bernot, Jeffrey M. Howell
Publikováno v:
Enzyme and Microbial Technology. 26:348-358
Allysine ethylene acetal [(S)-2-amino-5-(1,3-dioxolan-2-yl)-pentanoic acid (2)] was prepared from the corresponding keto acid by reductive amination using phenylalanine dehydrogenase (PDH) from Thermoactinomyces intermedius ATCC 33205. Glutamate, ala
Autor:
Laszlo J. Szarka, Venkata B. Nanduri, Ronald L. Hanson, Ramesh N. Patel, Ko Raphael Y, Laporte Thomas L
Publikováno v:
Biotechnology and Bioengineering. 48:547-550
10-Deacetylabaccatin III (10 DAB), an important precursor for paclitaxel semisynthesis, is enhanced in yew extracts using C10-deacetylase and C13-deacylase enzymes.(4) C10-deacetylase is an intracellular enzyme produced by the fermentation of a soil
Autor:
David B. Brzozowski, Laszlo J. Szarka, Ronald L. Hanson, Amit Banerjee, Ramesh N. Patel, Clyde G. McNamee
Publikováno v:
Enzyme and Microbial Technology. 15:1014-1021
The key chiral intermediate 3,5-dihydroxy-6-(benzyloxy) hexanoic acid, ethyl ester 2a, was made by the stereoselective microbial reduction of 3,5-dioxo-6-(benzyloxy) hexanoic acid, ethyl ester 1. Among various microbial cultures evaluated, cell suspe
Publikováno v:
Biotechnology and applied biochemistry. 39(Pt 2)
6-alpha-Hydroxy-7-deoxy-10-deacetylbaccatin-III is an intermediate that is potentially useful for synthesis of analogues of paclitaxel. Screening of microbial strains identified an enzyme activity in Nocardioides luteus SC 13912 (A.T.C.C. 55426) whic
Publikováno v:
Applied microbiology and biotechnology. 37(5)
Biotransformations were developed to oxidize N epsilon-carbobenzoxy(CBZ)-L-lysine and to reduce the product keto acid to L-CBZ-oxylysine. Lysyl oxidase (L-lysine: O2 oxidoreductase, EC 1.4.3.14) from Trichoderma viride was relatively specific for L-l