Zobrazeno 1 - 10
of 18
pro vyhledávání: '"William C. Hunter"'
Autor:
Zhongkui Hong, Michael A. Hill, Stephen F. Vatner, Hongyu Qiu, Zhe Sun, Yi Zhu, Zhaohui Li, William C. Hunter, Gerald A. Meininger, Dorothy E. Vatner, Jerome P. Trzeciakowski
Publikováno v:
Aging Cell. 11:741-750
Summary A spectral analysis approach was developed for detailed study of time-resolved, dynamic changes in vascular smooth muscle cell (VSMC) elasticity and adhesion to identify differences in VSMC from young and aged monkeys. Atomic force microscopy
Autor:
William C. Hunter, Timothy Alcid
Publikováno v:
Biophysical Journal. 114:316a
Autor:
William C. Hunter, Timothy Alcid
Publikováno v:
Biophysical Journal. 114:502a
Autor:
William C. Hunter
Publikováno v:
Biophysical Journal. 108(2)
A compact model of cardiac sarcomere dynamics is useful when developing integrated models of whole ventricular function. Kinetic models can be simplified by separating slower from faster processes. The representation of faster processes can then be r
Autor:
Alison L. Schroeder, William C. Hunter
Publikováno v:
Biophysical Journal. 110(3):463a-464a
Experiments suggest that length changes alter activation in cardiac sarcomeres within a few milliseconds (Mateja & deTombe, 2012). Thus, the mechanism producing length-dependent activation must occur early in the contractile cycle, such as during the
Autor:
William C. Hunter
Publikováno v:
Cardiology Clinics. 18:443-457
Myocardial relaxation is governed by the interplay of two macromolecular systems: (1) myofilaments and (2) calcium extruding pumps/exchangers. In myocardium from failing hearts, both systems act more slowly than normal, and cause relaxation to decele
Publikováno v:
Europe PubMed Central
Length-dependent steady-state and dynamic responses of five models of isometric force generation in cardiac myofilaments were compared with similar experimental data from the literature. The models were constructed by assuming different subsets of th
Autor:
Hongyu Qiu, William C. Hunter, Zhe Sun, Nancy L Sehgel, Jerome P. Trzeciakowski, Gerald A. Meininger, Dorothy E. Vatner, Shumin Gao, Stephen F. Vatner, Yi Zhu
Publikováno v:
Biophysical Journal. 102(3)
An increase in vascular stiffness is a fundamental component of hypertension. Our hypothesis is that the increased large artery stiffness in hypertension is due in part to intrinsic properties of vascular smooth muscle cells (VSMCs). Adult spontaneou
Autor:
Dorothy E. Vatner, Zhe Sun, Yi Zhu, Christophe Depre, Hongyu Qiu, Stephen F. Vatner, Gerald A. Meininger, Jerome P. Trzeciakowski, William C. Hunter
Publikováno v:
The FASEB Journal. 25
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H1013-H1024
We present a mechanical assay for estimating the time course of Ca2+ bound to low-affinity sites on troponin C (TnC) in twitching rabbit papillary muscle. The assay is based on a theoretical correlation between the rate of force redevelopment after d