Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kunhong Xiao"'
Autor:
Jing-Yu Lin, Changxiu Qu, Qi Liu, Changwen Jin, Peng Sun, Sheng-chao Guo, Xiaoyan Wang, Xiaogang Niu, Zhao Yang, Zhen Xu, Zijian Li, Peng Xiao, Kunhong Xiao, Zhongliang Zhu, Fahui Li, Qing-tao He, Xin Chen, Zheng Gong, Ke Ruan, Jiangyun Wang, Shao-le Song, Jin-Peng Sun, Kong-kai Zhu, Feng Zhang, Qian-wen Wang, Fan Yang, Zhao-ya Yang, Wei Kong, Xiao Yu, Xiao-xuan Lyu, Ming-Jie Han, Shen-Ming Huang, Alem W. Kahsai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Characterization of the dynamic conformational changes in membrane protein signaling complexes by nuclear magnetic resonance (NMR) spectroscopy remains challenging. Here we report the site-specific incorporation of 4-trimethylsilyl phenylalanine (TMS
Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2
Autor:
Shen-Ming Huang, Peng Xiao, Changwen Jin, Zhongliang Zhu, Ru-Jia Zhao, Xiaogang Niu, Jing-Yu Lin, Qing-Tao He, Kunhong Xiao, Xiaona Tao, Fan Yang, Jiangyun Wang, Xiao Yu, Feng-Yuan Gao, Jin-Peng Sun, Yingli Jia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Arrestins recognize different receptor phosphorylation patterns and convert this information to selective arrestin functions to expand the functional diversity of the G protein-coupled receptor (GPCR) superfamilies. However, the principles governing
Autor:
Irene Coin, Vasyl Bondarenko, Pei Tang, Ieva Sutkeviciute, Pemra Doruker, Frederic Jean-Alphonse, Fei Fang, Thore Böttke, Lisa J. Clark, Jean-Pierre Vilardaga, Saifei Lei, Thomas J. Gardella, Alex D. White, Kunhong Xiao, Ji Young Lee, Ivet Bahar, James Krieger
Publikováno v:
Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2020, 16 (10), pp.1096-1104. ⟨10.1038/s41589-020-0567-0⟩
Nature chemical biology
Nature Chemical Biology, Nature Publishing Group, 2020, 16 (10), pp.1096-1104. ⟨10.1038/s41589-020-0567-0⟩
Nature chemical biology
International audience; Peptide ligands of class B G protein-coupled receptors (GPCRs) act via a two-step binding process, but the essential mechanisms that link their extracellular binding to intracellular receptor–arrestin interactions are not fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80067b92e1a48922060c62a5fda370ac
https://hal.archives-ouvertes.fr/hal-03117168
https://hal.archives-ouvertes.fr/hal-03117168
Autor:
Jiangyun Wang, Zhongliang Zhu, Xiaogang Niu, Kong-kai Zhu, Alem W. Kahsai, Fahui Li, Xin Chen, Zhao Yang, Zheng Gong, Xiao-xuan Lyu, Ming-Jie Han, Jin-Peng Sun, Shao-le Song, Wei Kong, Zhen Xu, Xiao Yu, Shen-Ming Huang, Ke Ruan, Changwen Jin, Qian-wen Wang, Qi Liu, Qing-tao He, Kunhong Xiao, Sheng-chao Guo, Zhao-ya Yang, Xiao-yan Wang, Changxiu Qu, Peng Sun, Feng Zhang, Jing-Yu Lin, Fan Yang, Peng Xiao
While one dimensional1H nuclear magnetic resonance (1D1H-NMR) spectroscopy is one of the most important and convenient method for measuring conformation change in biomacromolecules, characterization of protein dynamics in large membrane protein compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345e2299b9f67e91b577f4e3a2f826d4
Autor:
Lei Wang, Qiangmin Zhang, Hongda Liu, Yang Zhao, Tatyana Mamonova, Kunhong Xiao, Cheng Zhang, Sheng Li, Dawei Wang, Peter A. Friedman
Publikováno v:
Anal Chem
Hydrogen−deuterium exchange-mass spectrometry (HDXMS) is a powerful technology to characterize conformations and conformational dynamics of proteins and protein complexes. HDXMS has been widely used in the field of therapeutics for the development
Autor:
Yang Zhao, Kunhong Xiao
Publikováno v:
Beta-Arrestins ISBN: 9781493991570
β-Arrestins are key regulation proteins for G protein-coupled receptors (GPCRs) signaling. Experimental evidence suggests that β-arrestins undergo conformational changes concomitant with binding to activated, phosphorylated GPCRs. We developed a ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c027685697231d0d14df692c5a566ae
https://doi.org/10.1007/978-1-4939-9158-7_18
https://doi.org/10.1007/978-1-4939-9158-7_18
Publikováno v:
Biochemical and biophysical research communications. 487(2)
Eicosapentaenoic acid (EPA), an n-3 polyunsaturated fatty acid (PUFA), has been shown to decrease the risk of atherosclerosis by attenuating endothelial activation. In this study, we used mass spectrometry-based label-free quantitative proteomics to
Autor:
Sachdev S. Sidhu, Brian K. Kobilka, Xin Chen, Li-Yin Huang, Arun K. Shukla, Austin N. Oleskie, Minjung Choi, Sheng Li, Ling Ling Gu, Anthony A. Kossiakoff, Jiang Qian, Gerwin Westfield, Rosana I. Reis, Robert J. Lefkowitz, Shohei Koide, Alem W. Kahsai, Georgios Skiniotis, Jin Ming Shan, Adi Blanc, Prachi Tripathi-Shukla, Pawel A. Penczek, Cui Rong Liang, Rachel Hanna, Anne M. Dosey, Bjoern U. Klink, Xiao Jie Yao, Kunhong Xiao, Min Su, Virgil L. Woods
Publikováno v:
Nature
Single-particle electron microscopy and hydrogen–deuterium exchange mass spectrometry are used to characterize the structure and dynamics of a G-protein-coupled receptor–arrestin complex. Much has been learned about the structure of G-protein-cou
Autor:
Arun K. Shukla, Seungkirl Ahn, Robert J. Lefkowitz, Alem W. Kahsai, Terrence G. Oas, Jin-Peng Sun, Sudarshan Rajagopal, Kunhong Xiao
Publikováno v:
Nature Chemical Biology. 7:692-700
Seven-transmembrane receptors (7TMRs), also called G protein-coupled receptors (GPCRs), represent the largest class of drug targets, and they can signal through several distinct mechanisms including those mediated by G proteins and the multifunctiona
Publikováno v:
The Journal of biological chemistry. 279(53)
Beta-arrestins are multifunctional adaptor proteins, which mediate desensitization, endocytosis, and alternate signaling pathways of seven membrane-spanning receptors (7MSRs). Crystal structures of the basal inactive state of visual arrestin (arresti