Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Itaru Kojima"'
Autor:
Toshiko Kajita, Tsutomu Sasaki, Tatsuo Ishizuka, Ichiro Mori, Itaru Kojima, Kazuo Kajita, Takayuki Hanamoto, Hideyuki Okada, Takashi Sato, Taro Usui, Tadahiro Kitamura, Yoshihiko Kitada, Koichiro Taguchi, Hiroyuki Morita, Takahide Ikeda
Publikováno v:
FEBS Letters. 588:1935-1941
Androgen reduces fat mass, although the underlying mechanisms are unknown. Here, we examined the effect of testosterone on heat production and mitochondrial biogenesis. Testosterone-treated mice exhibited elevated heat production. Treatment with test
Publikováno v:
Biochemical and Biophysical Research Communications. 416:58-63
GPR119 is one of the G-protein-coupled receptors expressed in pancreatic β-cells and intestinal endocrine cells. Since agonists to GPR119 stimulate glucose-dependent insulin secretion, GPR119 agonists are anticipated to promote anti-diabetic effects
Publikováno v:
Endocrine Journal. 56:235-243
While the physiological role for calcium in the insulin action on glucose transport has been disputed, it was reassessed in a recent study by using a calcum chelator, 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid, tetra(acetoxymethyl) este
Autor:
Itaru Kojima, Chikara Sato, Masahiro Sokabe, Keiji Naruse, Masahiro Nagasawa, Hidetoshi Iida, Makoto Kanzaki
Publikováno v:
Science. 285:882-886
Calcium-permeable, stretch-activated nonselective cation (SA Cat) channels mediate cellular responses to mechanical stimuli. However, genes encoding such channels have not been identified in eukaryotes. The yeast MID1 gene product (Mid1) is required
Autor:
Shigeyasu Tanaka, Yoichi Suzuki, Hiroshi Shibata, Itaru Kojima, Takeshi Suzuki, Kuniaki Takata, Waka Omata
Publikováno v:
Biochemical and Biophysical Research Communications. 241:401-406
We have investigated the subcellular distribution of GLUT4 by immunofluorescence microscopy after transfection with wild-type or mutant dynamin cDNA into Chinese hamster ovary cells expressing insulin receptor and GLUT4. In the basal state, GLUT4 was
Publikováno v:
Journal of Biological Chemistry. 272:14733-14739
When the calcium-permeable cation channel CD20 is expressed in Balb/c 3T3 cells, it is activated by insulin-like growth factor-I (IGF-I) via the IGF-I receptor (Kanzaki, M., Nie, L., Shibata, H., and Kojima, I. (1997) J. Biol. Chem. 272, 4964-4969).
Publikováno v:
Journal of Biological Chemistry. 272:4964-4969
CD20 functions as a calcium-permeable cation channel. When expressed in Balb/c 3T3 cells, CD20 accelerates the G1 progression induced by insulin-like growth factor-I (IGF-I). To further characterize how CD20 modulates the action of IGF-I, we investig
Autor:
Jun-ichi Miyazaki, Fumiyasu Satou, Hiroshi Shibata, Hideki Ohnota, Romi Nobusawa, Itaru Kojima, Hideo Mogami
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 269:293-298
We studied the mechanism of action of KAD-1229, a non-sulfonylurea compound shown to stimulate insulin secretion, in a glucose responsive insulinoma cell line, MIN 6 cells. In microsomal fraction of MIN 6 cells, KAD-1229 displaced binding of [3H]glib
Publikováno v:
Biochemical and Biophysical Research Communications. 202:422-428
Production of follistatin in cultured rat hepatocytes was studied by measuring follistatin release with a protein-binding assay using [125I]activin A. Follistatin was detected in conditioned medium of cultured hepatocytes. Ligand blotting using [125I
Autor:
Itaru Kojima, H. Mogami
Publikováno v:
Biochemical and Biophysical Research Communications. 196:650-658
The present study was conducted to determine a role of calcium entry in the growth promoting action of platelet-derived growth factor (PDGF) in cultured rat vascular smooth muscle cells. Addition of PDGF to quiescent cells induced a rapid elevation o