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pro vyhledávání: '"William C. Hunter"'
Autor:
William C. Hunter
Publikováno v:
Cardiology Clinics. 18:443-457
Myocardial relaxation is governed by the interplay of two macromolecular systems: (1) myofilaments and (2) calcium extruding pumps/exchangers. In myocardium from failing hearts, both systems act more slowly than normal, and cause relaxation to decele
Autor:
Hongyu Qiu, William C. Hunter, Zhe Sun, Nancy L Sehgel, Jerome P. Trzeciakowski, Gerald A. Meininger, Dorothy E. Vatner, Shumin Gao, Stephen F. Vatner, Yi Zhu
Publikováno v:
Biophysical Journal. 102(3)
An increase in vascular stiffness is a fundamental component of hypertension. Our hypothesis is that the increased large artery stiffness in hypertension is due in part to intrinsic properties of vascular smooth muscle cells (VSMCs). Adult spontaneou
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H1013-H1024
We present a mechanical assay for estimating the time course of Ca2+ bound to low-affinity sites on troponin C (TnC) in twitching rabbit papillary muscle. The assay is based on a theoretical correlation between the rate of force redevelopment after d
Autor:
Zhe Sun, William C. Hunter, Dorothy E. Vatner, Nancy L. Sehgel, Jerome P. Trzeciakowski, Stephen F. Vatner, Yi Zhu, Gerald A. Meininger
Publikováno v:
Biophysical Journal. 106:356a
Hypertension and aging are both recognized to increase aortic stiffness, but the underlying mechanisms are not completely understood. Most prior studies have attributed increased aortic stiffness to mechanical changes within the extracellular matrix
Publikováno v:
Journal of Molecular and Cellular Cardiology. 20:415-426
To determine whether catecholamines produce alterations in myocardial myosin-actin cycling kinetics, we investigated the effects of isoproterenol upon mechanical characteristics of constantly activated heart muscle thought to reflect crossbridge beha