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Publikováno v:
Biochemical and Biophysical Research Communications. 630:24-29
Non-small cell lung carcinomas (NSCLCs), especially lung adenocarcinomas (LUADs), harbor several driver mutations against which highly effective tyrosine kinase inhibitors (TKIs) are available. Although TKIs are generally effective against certain NS
Autor:
Ayaka Imai, Mano Horinaka, Yuichi Aono, Yosuke Iizumi, Hideki Takakura, Hisako Ono, Shusuke Yasuda, Keiko Taniguchi, Emi Nishimoto, Hideki Ishikawa, Michihiro Mutoh, Toshiyuki Sakai
Publikováno v:
Biochemical and Biophysical Research Communications. 628:110-115
Colorectal cancer is a significant cause of morbidity and represents a serious public health issue in many countries. The development of a breakthrough preventive method for colorectal cancer is urgently needed. Aspirin has recently been attracting a
Autor:
Tasuku Nishino, Takaya Abe, Mari Kaneko, Masanao Yokohira, Keiko Yamakawa, Katsumi Imaida, Hiroaki Konishi
Publikováno v:
Biochemical and Biophysical Research Communications. 628:91-97
The adaptor protein GAREM has two subtypes. Each is involved in Erk activation signaling downstream of the cell growth factor receptor in cultured cells. Regarding their role in individual animals, we have previously reported that mice deficient in G
Publikováno v:
Biochemical and Biophysical Research Communications. 630:175-182
Lung adenocarcinoma (LUAD) is the most common type of lung cancers, which remains the leading cause of cancer-related death worldwide. Drebrin can promote cell migration and invasion with poor prognosis, but its roes in LUAD tumor progression remains
Autor:
Hui Feng, Yi Liu, Mengyao Zhang, Ruimin Liu, Jincheng Wang, Wenjuan Wang, Pengcheng He, Penghui Zhang, Fan Niu
Publikováno v:
Biochemical and Biophysical Research Communications. 629:152-158
Acute myeloid leukemia (AML) is the most common blood cancer in adults. Patients' 5-year overall survival is less than 30% thus having a poor prognosis. To date, the development of novel target therapies is still necessary to ameliorate patients' sur
Publikováno v:
Biochemical and Biophysical Research Communications. 631:130-137
The mammalian target of rapamycin (mTOR)-composed of multiple complexes, including mTOR complex 1/2 (mTORC1/2)-is a serine-threonine kinase that regulates embryonic development. The transcription factor, hypoxia-inducible factor-1α (HIF-1α), is als
Publikováno v:
Biochemical and Biophysical Research Communications. 630:77-83
Previous studies found that irisin attenuated the vascular wall inflammation caused by Oxidized low-density lipoprotein (ox-LDL), and recent experiments have shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) can act on various cells in
Autor:
Zohreh Jahani, Jamshid Davoodi
Publikováno v:
Biochemical and Biophysical Research Communications. 629:71-77
Anti-diabetic drug, metformin, has attracted attentions as an anti-cancer agent due to the suppression of mTORC1 as a master switch of cell growth in various cancers. Upon mTORC1 inhibition, translation of proteins possessing IRES elements in their m
Publikováno v:
Biochemical and Biophysical Research Communications. 630:133-142
The phenotypic transformation of vascular smooth muscle cells (VSMCs) plays a key role in the pathological process of atherosclerosis (AS), and TRPM7 is involved in this process. In this study, we verified whether circRNAs participate in the phenotyp
Autor:
SooHo Rho, Jeong Kuk Park, Yeo Won Sim, Min Hee Choi, Nayoung Kwon, MinJu Kim, WeonSeok Jung, JooYoung Kim, Ju Hyeon Kim, Si Hyeock Lee, SangYoun Park
Publikováno v:
Biochemical and Biophysical Research Communications. 631:64-71
The human parasitic head and body lice lay their eggs on either hair or clothing. Attachments of the eggs are possible because the female lice secret a glue substance from the accessory gland along with the egg, which hardens into a nit sheath that s