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Publikováno v:
FEBS Letters. 596:2617-2629
Regulation of cellular catabolic metabolism in immune cells has recently become a major concept for resolution of inflammation. Nuclear receptors (NRs), including peroxisome proliferator activator receptors, 1,25-dihydroxyvitamin D (3) receptor, live
Publikováno v:
FEBS Letters. 596:1981-1993
Nuclear factor erythroid-derived 2-like 2 (NRF2) is a master transcription factor that coordinately regulates the expression of many cytoprotective genes and plays a central role in defense mechanisms against oxidative and electrophilic insults. Alth
Autor:
Bhawna Singh, Shalini Roy Chowdhury, Mohammad Shoab Mansuri, Saraswathi Jayarajan Pillai, Sonam Mehrotra
Publikováno v:
FEBS Letters. 596:2041-2055
DNA replication stress is characterized by impaired replication fork progression, causing some of the replication forks to collapse and form DNA breaks. It is a primary cause of genomic instability leading to oncogenic transformation. The repair-inde
Publikováno v:
FEBS Lett
Mitochondrial dysfunction is known to contribute to a range of diseases, and primary mitochondrial defects strongly impact high-energy organs such as the heart. Platforms for high-throughput and human-relevant assessment of mitochondrial diseases are
Publikováno v:
FEBS Letters. 596:2497-2512
Microscopic analysis of molecules and physiology in living cells and systems is a powerful tool in life sciences. While in vivo subcellular microscopic analysis of healthy and diseased human organs remains impossible, zebrafish larvae allow studying
Publikováno v:
Juni, R P, 't Hart, K C, Houtkooper, R H & Boon, R A 2022, ' Long noncoding RNAs in cardiometabolic disorders ', FEBS Letters, vol. 596, no. 11, pp. 1367-1387 . https://doi.org/10.1002/1873-3468.14370
The advancement of medical technology has led not only to an increase in life expectancy but also to a rise in aging-related diseases. Aging promotes metabolic disorders, in turn affecting cardiovascular health. Derailment of biological processes in
Autor:
Marina Barba‐Aliaga, Paula Alepuz
Publikováno v:
FEBS Letters. 596:1809-1826
Mitochondrial activity adapts to cellular energetic and metabolic demands; its dysfunction is a hallmark of ageing and many human diseases. The evolutionarily conserved translation elongation factor eIF5A is involved in maintaining mitochondrial func
Autor:
Andrea L. Miranda, Lucille T. Kourdova, Ana C. Racca, Mariano Cruz Del Puerto, Maria L. Rojas, Aldilane L. X. Marques, Elaine C. O. Silva, Eduardo J. S. Fonseca, Yamila Gazzoni, Adriana Gruppi, Alexandre U. Borbely, Susana Genti‐Raimondi, Graciela M. Panzetta‐Dutari
Publikováno v:
FEBS Letters. 596:1700-1719
Trophoblast cell differentiation is of paramount importance for successful pregnancy. Krüppel-like factor 6 (KLF6), a transcription factor with diverse roles in cell physiology and tumor biology, is required for trophoblast differentiation through t
Publikováno v:
Annual Review of Biophysics. 51:409-429
The folding of proteins into their native structure is crucial for the functioning of all biological processes. Molecular chaperones are guardians of the proteome that assist in protein folding and prevent the accumulation of aberrant protein conform
Publikováno v:
Annual Review of Biophysics. 51:115-133
The chaperonins are ubiquitous and essential nanomachines that assist in protein folding in an ATP-driven manner. They consist of two back-to-back stacked oligomeric rings with cavities in which protein (un)folding can take place in a shielding envir