Zobrazeno 1 - 10
of 5 314
pro vyhledávání: ''
Autor:
Fumio Sakane, Fumi Hoshino
Publikováno v:
Biochemical and Biophysical Research Communications
The clathrin coat assembly protein AP180 drives endocytosis, which is crucial for numerous physiological events, such as the internalization and recycling of receptors, uptake of neurotransmitters and entry of viruses, including SARS-CoV-2, by intera
Publikováno v:
Biochemical and Biophysical Research Communications. 585:15-21
NMDAR (N-methyl-d-aspartate receptor) consisted of GluN1 and GluN2, and/or GluN3 subunits. As the obligatory subunit of NMDAR, GluN1 contains variant N-terminal domain (NTD) and C-terminal domain (CTD). The CTD contains allosteric signal and mediates
Autor:
Yasuko Orba, William W. Hall, Shinsuke Toba, Takao Sanaki, Kentaro Uemura, Hirofumi Sawa, Akihiko Sato, Yukari Itakura, Koshiro Tabata, Kittiya Intaruck, Michihito Sasaki, Mai Kishimoto
Publikováno v:
Biochemical and Biophysical Research Communications
The human lung cell A549 is susceptible to infection with a number of respiratory viruses. However, A549 cells are resistant to Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection in conventional submerged culture, and this would a
Publikováno v:
ACS Chemical Neuroscience. 12:4162-4174
A molecular inhibitor of tau protein aggregation offers an attractive therapeutic possibility as disease-modifying treatment of Alzheimer's disease. However, the ineffectiveness as well as adjoint toxicity due to superficial understanding of the inhi
Association of Fpr1 gene expression with osteogenesis and adipogenesis of adipose derived stem cells
Publikováno v:
Biochem Biophys Res Commun
Formyl peptide receptors (Fprs) play fundamental roles in multiple cell functions including promotion of osteogenesis and bone fracture healing. In this study, the role of Fpr1 gene in osteogenic and adipogenic differentiation of adipose derived stem
Publikováno v:
FEBS Letters. 595:2628-2637
We recently reported a physical interaction between the angiotensin II (AngII) receptor (AT1R) and thrombin receptor (PAR1) in HEK293 cells using bioluminescence resonance energy transfer (BRET) technology. This was characterized by thrombin trans-ac
Autor:
Hideoki Ogawa, Yasuko Nagatsuka, Madoka Kage, Tomomi Hotta, Yoshio Hirabayashi, Kenji Takamori, Kazuhisa Iwabuchi, Hitoshi Nakayama, Kei Hanafusa, Koki Kano, Ichiro Matsuo, Eriko Oshima, Noriko Yokoyama, Xiaojia Li
Publikováno v:
Biochemical and Biophysical Research Communications. 569:86-92
Neutrophils undergo spontaneous apoptosis within 24–48 h after leaving bone marrow. Apoptotic neutrophils are subsequently phagocytosed and cleared by macrophages, thereby maintaining neutrophil homeostasis. Previous studies have demonstrated invol
Autor:
Marko Lilic, Eamonn F. Healy
Publikováno v:
Biochemical and Biophysical Research Communications
The angiotensin Converting Enzyme 2 (ACE2) receptor is a key component of the renin-angiotensin-aldesterone system (RAAS) that mediates numerous effects in the cardiovascular system. It is also the cellular point of contact for the coronavirus spike
Autor:
Weijian Gong, Nicole Ashman, Erdinc Sezgin, Iztok Urbančič, Caitlin O’Brien-Ball, Falk Schneider, Mai Tuyet Vuong, Edward Jenkins, Christian Eggeling, Ana Filipa L.O.M. Santos, Lisa Schiffelers
Publikováno v:
FEBS Letters. 595:2127-2146
To disentangle the elusive lipid-protein interactions in T-cell activation, we investigate how externally imposed variations in mobility of key membrane proteins (T-cell receptor [TCR], kinase Lck, and phosphatase CD45) affect the local lipid order a
Publikováno v:
Biochemical and Biophysical Research Communications. 562:15-20
Bile acids play essential roles in facilitating the intestinal absorption of lipophilic nutrients as well as regulation of glucose, lipid, and energy homeostasis via activation of some receptors. Bile acids are cytotoxic, and consequently their conce