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Publikováno v:
Petrlova, J, Samsudin, F, Bond, P J & Schmidtchen, A 2022, ' SARS-CoV-2 spike protein aggregation is triggered by bacterial lipopolysaccharide ', FEBS Letters, vol. 596, no. 19, pp. 2566-2575 . https://doi.org/10.1002/1873-3468.14490
SARS-CoV-2 spike (S) protein is crucial for virus invasion in COVID-19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of S protein aggregates by micro
Autor:
Pooppadi Maxin Sayeesh, Teppei Ikeya, Haruka Sugasawa, Riki Watanabe, Masaki Mishima, Kohsuke Inomata, Yutaka Ito
Publikováno v:
Biochemical and biophysical research communications. 625
Drk, a Drosophila homologue of human GRB2, interacts with Sevenless (Sev) receptor via its SH2 domain, while the N- and C-terminal SH3 domains (Drk-NSH3 and Drk-CSH3, respectively) are responsible for the interaction with proline-rich motifs (PRMs) o
Autor:
Vijay Kumar, Danish Idrees
Publikováno v:
Biochemical and Biophysical Research Communications
The post-infection of COVID-19 includes a myriad of neurologic symptoms including neurodegeneration. Protein aggregation in brain can be considered as one of the important reasons behind the neurodegeneration. SARS-CoV-2 Spike S1 protein receptor bin
Autor:
Birgit Kastberger, Adrien Joly, Ralph T. Böttcher, Reinhard Fässler, Zeynep Karatas, Bernhard Wehrle-Haller, Thomas Orré, Jean-Baptiste Sibarita, Clément Cabriel, Olivier Rossier, Sandrine Lévêque-Fort, Grégory Giannone
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-23372-w⟩
Nature Communications, Vol. 12, No 1 (2021) P. 3104
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-23372-w⟩
Nature Communications, Vol. 12, No 1 (2021) P. 3104
Focal adhesions (FAs) initiate chemical and mechanical signals involved in cell polarity, migration, proliferation and differentiation. Super-resolution microscopy revealed that FAs are organized at the nanoscale into functional layers from the lower
Publikováno v:
Biochemical and Biophysical Research Communications. 553:9-16
The RNA-binding protein Ataxin-2 regulates translation and mRNA stability through cytoplasmic polyadenylation of the targets. Here we newly identified DDX6 as a positive regulator of the cytoplasmic polyadenylation. Analysis of Ataxin-2 interactome u
Autor:
Daisuke Fuji, Takashi Kawakami, Takumi Yokoyama, Mizuki Yamamoto, Rina Iwamoto, Takehiro Ando
Publikováno v:
Biochemical and Biophysical Research Communications. 553:148-153
The interaction of human epidermal growth factor receptor 3 (HER3) and heregulin (HRG) is involved in resistance to human epidermal growth factor receptor 2 (HER2)-targeted cancer treatment, such as therapies using anti-HER2 monoclonal antibody. Ther
Autor:
Yuki Shimizu, Akihiko Tsuji, Shogo Abe, Maki Shimada, Mika Nishida, Kenji Miyamoto, Keizo Yuasa
Publikováno v:
Biochemical and Biophysical Research Communications. 552:9-16
Although natriuretic peptide receptor-C (NPR-C) is involved in the clearance of natriuretic peptides from plasma, it also possesses other physiological functions, such as inhibition of adenylyl cyclase activity through Gαi. However, the physiologica
Autor:
Tetsuya Hirata, Yi-Shi Liu, Xiao-Dong Gao, Xin-Yu Guo, Morihisa Fujita, Taroh Kinoshita, Jing Yang
Publikováno v:
FEBS Letters. 595:1542-1558
Over 100 glycosylphosphatidylinositol-anchored proteins (GPI-APs) are encoded in the mammalian genome. It is not well understood how these proteins are targeted and translocated to the endoplasmic reticulum (ER). Here, we reveal that many GPI-APs, su
Publikováno v:
Febs Letters
Recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (B.1.1.7 and B.1351) have emerged harbouring mutations that make them highly contagious. The N501Y mutation within the receptor-binding domain (RBD) of the spike protein
Autor:
Kyoko Shida, Fumiji Saito, Sawako Itagaki, Kouyuki Hirayasu, Masako Kohyama, Wataru Nakai, Akihito Sakoguchi, Sumiko Matsuoka, Toshihiro Horii, Shiroh Iwanaga, Hisashi Arase, Tadahiro Suenaga
Publikováno v:
Biochemical and Biophysical Research Communications. 548:167-173
Plasmodium falciparum causes the most severe form of malaria. Acquired immunity against P. falciparum provides insufficient protection even after repeated infections. Therefore, P. falciparum parasites might exploit inhibitory receptors for immune ev