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Autor:
Su-Xia Sun, Hao Zhang, Xian-Chao Cheng, Zhihui Zheng, Ting-Ting Ding, Run-Ling Wang, Li-Song Zhang, Yang-Chun Ma, Xin-Hua Lu, Ya-Ya Liu
Publikováno v:
Biochemical and Biophysical Research Communications. 579:40-46
Protein tyrosine phosphatase 1B (PTP1B) is a member of the phosphotyrosine phosphatase family and plays an important role in the signal transduction of diabetes. Inhibition of PTP1B activity can increase insulin sensitivity and reduce blood sugar lev
Publikováno v:
Biochemical and Biophysical Research Communications. 576:108-116
Ras-related GTP binding (Rag) GTPases are required to activate mechanistic target of rapamycin complex 1 (mTORC1), which plays a central role in cell growth and metabolism and is considered as one of the most important oncogenic pathways. Therefore,
Publikováno v:
Biochemical and Biophysical Research Communications. 570:117-124
Kinesin Family Member 15 (KIF15) is a plus end-directed microtubule motor, which exerts complex regulations in cancer biology. This study aimed to explore the functional role of KIF15 in leiomyosarcoma (LMS). Bioinformatic analysis was carried out us
Publikováno v:
Biochemical and Biophysical Research Communications. 569:106-111
ALS2, a product of the causative gene for familial amyotrophic lateral sclerosis (ALS) type 2, plays a pivotal role in the regulation of endosome dynamics by activating small GTPase Rab5 via its intrinsic guanine nucleotide-exchange factor activity.
Autor:
Trong-Nhat Phan, Joo Hwan No, Jiho Kim, Hyeryon Lee, Kyung-Hwa Baek, I Seul Park, Sang Chul Lee
Publikováno v:
Biochemical and Biophysical Research Communications. 569:193-198
Visceral leishmaniasis (VL) is a fatal infectious disease caused by viscerotropic parasitic species of Leishmania. Current treatment options are often ineffective and toxic, and more importantly, there are no clinically validated drug targets availab
Autor:
Jinrong Min, Aiping Dong, Peter Loppnau, Mengqi Zhou, Yinxue Yang, Yanli Liu, Xuemei Yan, Mengmeng Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 569:199-206
The NSD proteins, namely NSD1, NSD2 and NSD3, are lysine methyltransferases, which catalyze mono- and di-methylation of histone H3K36. They are multi-domain proteins, including two PWWP domains (PWWP1 and PWWP2) separated by some other domains. These
Publikováno v:
FEBS Letters. 595:2395-2409
Substrate-binding proteins (SBPs) mediate ligand translocation and have been classified into seven clusters (A-G). Although the substrate specificities of these clusters are known to some extent, their ligand-binding mechanism(s) remain(s) incomplete
Publikováno v:
Febs Letters
Heparan sulfate (HS), a sulfated glycosaminoglycan (GAG), was reported to be a necessary host attachment factor that promotes SARS-CoV-2 infection. In this study, we developed GAG microarrays based on fluorescence detection for high-sensitivity scree
Publikováno v:
FEBS Letters. 595:2248-2256
The endoplasmic reticulum transmembrane protein vesicle-associated membrane protein-associated protein (VAP) plays a central role in the formation and function of membrane contact sites (MCS) through its interactions with proteins. The major sperm pr
Autor:
Simon Sander, Ralf Fliegert, Trevor J. Rutherford, Henning Tidow, Ellen Gattkowski, Andreas Bauche, Franziska Möckl
Publikováno v:
The FEBS journal 288(23), 6769-6782 (2021). doi:10.1111/febs.16097
The FEBS journal 288(23), 6769 - 6782 (2021). doi:10.1111/febs.16097
Nudix hydrolase 9 (NUDT9) is a member of the nucleoside linked to another moiety X (NUDIX) protein superfamily, which hydrolyses a broad spectrum of organic pyrophosphates from
Nudix hydrolase 9 (NUDT9) is a member of the nucleoside linked to another moiety X (NUDIX) protein superfamily, which hydrolyses a broad spectrum of organic pyrophosphates from