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Publikováno v:
Biochemical and Biophysical Research Communications. 635:65-76
Cardiovascular events among patients with chronic kidney disease (CKD) are associated with vascular calcification (VC). Nevertheless, the process of vascular calcification is complicated. A mechanism of VC is cellular osteogenic transdifferentiation.
Autor:
Mahip K. Verma, Charudatt Samant, Ramesh Kale, Sukanya Patra, Nilesh Mahajan, Milind K. Gholve, Ajitkumar Marisetti, Brahmam Sunkara, Aditya Naik, Manisha Shingare, Madhusudhan Reddy, Anand M. Bokare, Atul Akarte, Sarita Koul, Prashant B. Nigade, Vinod B. Patil, Dipak Modi, Prajakta Ahirrao, Shashikant Pawar, Sandip Kuldharan, Lal Dinchhana, Maneesh Mehta, Jayasagar Gundu, Nirmal Jana, Prashant Vidhate, Sachin Jaysing Mahangare, Manojkumar R. Shukla, Rajan N. Goel, Mandar Bhonde, Rajender Kumar Kamboj, Venkata P. Palle
Publikováno v:
Biochemical and Biophysical Research Communications. 637:267-275
Phosphoinositide 3-kinase (PI3K) pathway mediates key signaling events downstream to B-cell receptor (BCR) for survival of mature B-cells, and overexpression or overactivation of PI3Kδ is crucial for B-cell malignancies such as diffuse large B-cell
Autor:
Anusha Jayaraman, Sven Pettersson
Publikováno v:
Biochemical and Biophysical Research Communications. 633:88-91
The human gut microbiota comprises of trillions of micro-organisms in the gut some which secrete metabolites that play a pivotal role in supporting optimal body and organ functions. These dynamic and malleable gut microbes share a bidirectional relat
Publikováno v:
Biochemical and Biophysical Research Communications. 637:331-340
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide with ill-defined etiology and pathogenesis, and no approved effective therapy is presently available. Exosome-dependent intercellular communication has been identified
Publikováno v:
Biochemical and Biophysical Research Communications. 635:128-135
To assess HOXC9 expression in non-small cell lung cancer (NSCLC) using bioinformatics analysis with experimental validation and to investigate its role and potential mechanisms in NSCLC.Public databases were explored to investigate the gene expressio
Publikováno v:
Biochemical and Biophysical Research Communications. 634:152-158
Acute lung injury (ALI), with high morbidity and mortality, is mainly resulted by infectious or non-infectious inflammatory stimulators, and it will further evolve into acute respiratory distress syndrome if not controlled. Fibroblast growth factors
Publikováno v:
Biochemical and Biophysical Research Communications. 636:197-204
High malignancy and mortality in colon cancer require clarifying the underlying mechanisms of colon cancer carcinogenesis and exploring new targets or drugs for the clinical treatment of colon cancer. Resveratrol (Res), a natural compound, shows cyto
Autor:
Fei Lu, Pengfei Liang, Bei Fan, Qingwen Zhu, Tao Xue, Zhenzhen Liu, Renfeng Wang, Yukai Zhang, Xinyu Zhang, Wei Li, Shujuan Wang, Jun Chen, Dingjun Zha
Publikováno v:
Biochemical and Biophysical Research Communications. 632:69-75
Autosomal recessive nonsyndromic auditory neuropathy is attributed to a genetic etiology. We identified a compound heterozygous missense variant, c.G736A (p.G246S) and c.C2954T (p.T985 M) in TNN of affected patients in a pedigree via candidate gene s
Publikováno v:
Biochemical and Biophysical Research Communications. 634:175-181
Oxygen is essential for aerobic organisms, but generates reactive oxygen species (ROS), which can cause cellular dysfunction by damaging cellular molecules. Many genes are involved in the regulation of ROS; however, much attention has not focused on
Autor:
Wansoo Kim, Dong-Yeop Yeo, Seong-Kyoon Choi, Hee-Yeon Kim, Seoung-Woo Lee, Janbolat Ashim, Jee Eun Han, Wookyung Yu, Hyohoon Jeong, Jin-Kyu Park, Song Park
Publikováno v:
Biochemical and Biophysical Research Communications. 635:99-107
Although several studies have focused on cancer diagnosis and therapy, prostate cancer (PC) remains an intractable disease. Androgen deprivation therapy (ADT), which is used to treat early stage PC can lead to the development of castration-resistant